Chuan Tian

Glutamine reprogramming affects the tumor microenvironment and immune response in hepatocellular carcinoma

Yong Sun, Yi Cui, Daiqin Luo, Chuan Tian

Glutamine, recognized as a conditionally essential amino acid, plays a crucial role in cellular metabolism and significantly impacts the tumor microenvironment. Recent studies show that glutamine metabolism directly influences the growth and survival of hepatocellular carcinoma (HCC) cells. Recent research demonstrates that …

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DEP domain containing 1: a potential oncogenic driver

Yi Cui, Weiwei Ouyang, Youyou Li, Chuan Tian

BACKGROUND: DEP domain-containing protein 1 (DEPDC1) is essential for cell cycle regulation and is increasingly associated with multiple cancers. Accumulating evidence demonstrates that DEPDC1 is significantly upregulated in tumor tissues than in non-malignant tissues across 31 cancer types. DEPDC1 overexpression has been …

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Clinical features, disease burden and impact on quality of life in participants with mitochondrial encephalomyopathy

John Sieh Dumbuya, Chuan Tian, Linhong Deng, Bashir Ahmad et autres

Background: Mitochondrial encephalomyopathy (ME) is a rare genetic disorder that significantly impacts participants' quality of life and places emotional and financial burdens on caregivers. However, the dynamics between perceived financial burden, disability, and caregiver strain are not fully understood. This study aimed …

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Retifanlimab with carboplatin and paclitaxel for locally recurrent or metastatic squamous cell carcinoma of the anal canal (POD1UM-303/InterAACT-2): a global, phase 3 randomised controlled trial

Sheela Rao, Emmanuelle Samalin-Scalzi, Ludovic Evesque, Méher Ben Abdelghani et autres

BACKGROUND: Retifanlimab has activity in programmed death ligand 1-positive advanced squamous cell anal carcinoma (SCAC) that has progressed on platinum chemotherapy. We aimed to prospectively assess the benefit of adding retifanlimab to initial carboplatin-paclitaxel for this disease. METHODS: This global, multicentre, double-blind, …

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Retraction Note: Linc-ROR facilitates progression and angiogenesis of hepatocellular carcinoma by modulating DEPDC1 expression

Chuan Tian, Mubalake Abudoureyimu, Xinrong Lin, Xiaoyuan Chu et autres

The Editors-in-Chief have retracted this article at the authors’ request. After publication, concerns were raised regarding potential image overlap in Figs. 4 and 6, specifically: Fig. 4b Hep3B DEPDC1 image appears to overlap with Fig. 6b Hep3B Lv-ROR; Fig. 4d HepG2 vec+miR-NC …

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YY1-mediated DUXAP8 facilitates HCC progression via modulating DEPDC1 expression

Yi Cui, Yong Sun, Na Liang, Chuan Tian

The long noncoding RNA DUXAP8 has been implicated in the progression of various malignancies, including hepatocellular carcinoma (HCC). Although there is increasing evidence of DUXAP8's role in tumor biology, the exact mechanisms by which it affects the development and treatment of HCC …

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Optimizing Collaboration of Large Language Model Based Agents for Autonomous Finite Element Analysis

Yilei Zhang, Chuan Tian

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Purrfessor: A Fine-tuned Multimodal LLaVA Diet Health Chatbot

Liwei Lu, Yifan Deng, Chuan Tian, Sijia Yang et autres

This study introduces Purrfessor, an innovative AI chatbot designed to provide personalized dietary guidance through interactive, multimodal engagement. Leveraging the Large Language-and-Vision Assistant (LLaVA) model fine-tuned with food and nutrition data and a human-in-the-loop approach, Purrfessor integrates visual meal analysis with contextual …

Transaortic and transfemoral stent deployment approaches related morphological and clinical outcomes after type II hybrid arch repair for type A aortic dissection

Chuan Tian, Yi Xiao, Kejian Hu, Chang Shu

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[Short-term results of a multicenter study based on a modified N7 induction regimen combined with arsenic trioxide in the treatment of children with high-risk neuroblastoma].

S. Yang, K L Chen, Yumin He, Xiaomin Peng et autres

ATO combined with N7-modified induction regimen had a superiority in efficacy and safety, which deserved further promotion in clinical practice.

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Collaboration Dynamics and Reliability Challenges of Multi-Agent LLM Systems in Finite Element Analysis

Chuan Tian, Yilei Zhang

Large Language Model (LLM)-based multi-agent systems are increasingly applied to automate computational workflows in science and engineering. However, how inter-agent dynamics influence reasoning quality and verification reliability remains unclear. We study these mechanisms using an AutoGen-based multi-agent framework for linear-elastic Finite Element …

Cross-sectional study on the impact of cardiac and hepatic iron overload, as measured by MRI T2*, on the quality of life in children with severe beta-thalassemia major

Zhonglv Ye, Jiayi Du, Lili Liu, Chuan Tian et autres

A cross-sectional study to explore the correlation between cardiac and hepatic iron overload and its impact on the quality of life in children diagnosed with severe beta-thalassemia major (β-TM). A cohort of 55 pediatric patients with β-TM, diagnosed via genetic testing at …

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