Yunlei Zhang

Toxicity-shielded Ag-Pt-ICG nanocomposite with photothermal-enhanced ionic release for lung cancer therapy

Min Gao, Gege Li, Xiaoran Zheng, Yang Yang et autres

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Factors associated with post-stroke depression one month after discharge among older patients based on Health Ecology Theory: a retrospective cross-sectional study of consecutive cases

Yunlei Zhang, Yao Liao, Huanhuan Liu

Objective This study aimed to examine multidimensional factors associated with post-stroke depression one month after discharge among older patients within the framework of Health Ecology Theory. Methods This retrospective cross-sectional study consecutively included 482 older stroke patients (aged ≥ 65 years) who …

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Microbial orchestration of neuroimmune crosstalk: from homeostasis to disease

Yang Yang, Xiuwei Zhang, Yiyao Cui, Yunlei Zhang

The gut-brain-immune axis represents a paradigm shift in understanding systemic homeostasis and disease. While microbial dysbiosis is firmly linked to a spectrum of neurological and immunological disorders, a critical gap persists in our mechanistic understanding of how gut microbes precisely orchestrate the …

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Observations and potential source regions of HFC-152a in southeastern China

Yulin Xu, Zhiwei Cao, Yonglong Lü, Zhaoyang Wu et autres

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Integrated ecological quality assessment of the sea area adjacent to the Yellow River estuary under multiple pollutants

Wen Li, Jinqing Ye, Xin Gao, Yunlei Zhang et autres

Estuaries are increasingly threatened by pollutants derived from human activities, which severely impair their water quality, biodiversity, and ecological functions. Therefore, within this context, it is essential to conduct comprehensive and scientifically rigorous assessments of estuarine ecological quality. Taking the Yellow River …

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Ultrafast solar dehalogenation of aromatic halides in water via diradical transformation in organic semiconductors

Yiying Zhou, Yunlei Zhang, Qingjun Yang, Pengwei Huo et autres

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Transcriptome response in a marine copepod under multigenerational exposure to ocean warming and Ni at an environmentally realistic concentration

Yunlei Zhang, Yaolu Niu, Xiaoping Zhou, Qingxian Lin

Due to anthropogenic activities, coastal areas have been challenged with multi-stresses such as ocean warming and nickel (Ni) pollution. Currently, studies have concerned the combined effects of Ni and warming in marine organisms at the phenotypic level; however, the underlying molecular mechanisms …

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Observations and Potential Source Regions of Hfc-152a in Southeastern China

Yulin Xu, Zhiwei Cao, Yonglong Lü, Pei Wang et autres

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Non-tuberculous mycobacteria enhance the tryptophan-kynurenine pathway to induce immunosuppression and facilitate pulmonary colonization

Longjie Li, Weiwei Gao, Pan Pan, Qi Chen et autres

The increasing prevalence of non-tuberculous mycobacterium (NTM) infections alongside tuberculosis (TB) underscores a pressing public health challenge. Yet, the mechanisms governing their infection within the lung remain poorly understood. Here, we integrate metagenomic sequencing, metabolomic sequencing, machine learning classifiers, SparCC, and MetOrigin …

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Projections of temperature and precipitation changes in Xinjiang from 2021 to 2050 based on the CMIP6 model

Yunlei Zhang, Pei Zhang, Xinchen Gu, Aihua Long

Xinjiang is one of the most sensitive regions in China in terms of its response to climate change. Against the background of global warming, analyses and predictions using different scenarios for Xinjiang should be conducted. The spatial and temporal distribution characteristics and …

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Liquid-liquid phase separation: a new perspective on respiratory diseases

Li Wang, Yongjun Wang, Z. J. Ke, Zexu Wang et autres

Liquid-liquid phase separation (LLPS) is integral to various biological processes, facilitating signal transduction by creating a condensed, membrane-less environment that plays crucial roles in diverse physiological and pathological processes. Recent evidence has underscored the significance of LLPS in human health and disease. …

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Redox‐Activated Substrates for Enhancing Activatable Cyclopropene Bioorthogonal Reactions

Wei‐Siang Kao, Wei Huang, Yunlei Zhang, K.-C. Wen et autres

Bioorthogonal chemistry has become a mainstay in chemical biology and is making inroads in the clinic with recent advances in protein targeting and drug release. Since the field's beginning, a major focus has been on designing bioorthogonal reagents with good selectivity, reactivity, …

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