Pan Pan

Autonomous artificial intelligence prescribing a drug to prevent severe acute graft-versus-host disease in HLA-haploidentical transplants

Junren Chen, Yigeng Cao, Yahui Feng, Saibing Qi et autres

Autonomous artificial intelligence (AI) models for deciding treatment strategies are available but rarely applied prospectively in clinical settings. Here we present a prospective study of deploying daGOAT, an algorithm we have developed, as a conditional autonomous AI agent to prescribe a drug …

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Effects of electroacupuncture on neural function and the expression of inflammation-related proteins NLRP3/caspase-1 in rats with ischemic stroke

Zhifeng Wang, Yujiang Xi, Ting Shi, Shuangfeng Xu et autres

This study aimed to investigate the neuroprotective effects of electroacupuncture (EA) at the Baihui and Dazhui acupoints in a rat model of ischemia-reperfusion injury. Ninety-six male Sprague-Dawley rats were randomly assigned to four groups ( n = 24 per group): Sham, middle …

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The ELF3-TRIM22-MAVS signaling axis regulates type I interferon and antiviral responses

Qiliang Zhao, Pan Pan, Mo Li, Jiangtao Wu et autres

Activation of the innate immune response is essential for host cells to restrict the dissemination of invading viruses and other pathogens. Proteins belonging to the tripartite motif (TRIM) family are key effectors in antiviral innate immunity. Among these, TRIM22, a RING-type E3 …

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Antiviral covalent ACE2 vesicle spray

Qian‐Fang Meng, Yu Han, Yu Liu, Pan Pan et autres

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Identification of antiviral RNAi regulators, ILF3/DHX9, recruit at ZIKV stem loop B to protect against ZIKV induced microcephaly

Zhiwei Lei, Yu Jeffrey Gu, Ying Liu, Hailiang Liu et autres

Zika virus (ZIKV) is a member of the Flaviviridae family and causes congenital microcephaly and Guillain–Barré syndrome. Currently, there is a lack of approved vaccines or therapies against ZIKV infection. In this study, we profile vRNA‒host protein interactomes at ZIKV stem‒loop B …

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Near-infrared high-precision CH4 and H2O sensor based on laser temperature variation and gas concentration averaging method

Hongliang Ma, Shiqi Wang, Guisheng Jiang, Lingli Li et autres

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Utilizing network pharmacology, pharmacodynamics, molecular biology studies, and molecular docking techniques to uncover the mechanism of the Ligusticum wallichii-borneol medication combination for the treatment of ischemic stroke in rat models

Pelser He, Zhifeng Wang, Pan Pan, Ting Shi et autres

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SARS-CoV-2 nucleocapsid protein interaction with YBX1 displays oncolytic properties through PKM mRNA destabilization

Xin Chen, Baohong Jiang, Yu‐Cheng Gu, Zhaoyang Yue et autres

BACKGROUND: SARS-CoV-2, a highly contagious coronavirus, is responsible for the global pandemic of COVID-19 in 2019. Currently, it remains uncertain whether SARS-CoV-2 possesses oncogenic or oncolytic potential in influencing tumor progression. Therefore, it is important to evaluate the clinical and functional role …

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Efficacy and Safety of Isavuconazole in the Treatment of Invasive Fungal Disease in Patients with Hematological Disorders

Nan Yang, Pan Pan, Aiming Pang, Erlie Jiang

Introduction: Invasive fungal infections (IFIs) are a significant contributor to morbidity and mortality in hematological malignancies (HM) patients and stem cell transplant (SCT) recipients. The FDA approved Isavuconazole (ISA) as a primary treatment for invasive aspergillosis and mucormycosis. This study aims to …

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Nicotine promotes M2 macrophage polarization through α5-nAChR/SOX2/CSF-1 axis in lung adenocarcinoma

Guiyu Kang, Hui Song, Bo Lei, Qi Liu et autres

α5-nicotinic acetylcholine receptor (α5-nAChR) plays a vital part in lung adenocarcinoma (LUAD). However, it is not comprehensively understood that how the α5-nAChR affects LUAD. Through diverse bioinformatics analyses and immunohistochemistry, the expressions of α5-nAChR and SOX2 as well as their relations were …

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Non-tuberculous mycobacteria enhance the tryptophan-kynurenine pathway to induce immunosuppression and facilitate pulmonary colonization

Longjie Li, Weiwei Gao, Pan Pan, Qi Chen et autres

The increasing prevalence of non-tuberculous mycobacterium (NTM) infections alongside tuberculosis (TB) underscores a pressing public health challenge. Yet, the mechanisms governing their infection within the lung remain poorly understood. Here, we integrate metagenomic sequencing, metabolomic sequencing, machine learning classifiers, SparCC, and MetOrigin …

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Identifying septic shock subgroups to tailor fluid strategies through multi-omics integration

Zhongheng Zhang, Lin Chen, Bin Sun, Zhanwei Ruan et autres

Fluid management remains a critical challenge in the treatment of septic shock, with individualized approaches lacking. This study aims to develop a statistical model based on transcriptomics to identify subgroups of septic shock patients with varied responses to fluid strategy. The study …

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