Chen Yang

24-h NIHSS score is the strongest prognostic predictor of 90-day outcome in cardioembolic stroke patients with anterior circulation occlusion after endovascular thrombectomy

Chen Yang, Yuehua Chen, Qingyan Liu, Ge Gong et autres

Background: This study aimed to evaluate and compare the predictive performance of the National Institutes of Health Stroke Scale (NIHSS) assessed at baseline, at 24 h, and derived change metrics for 90-day unfavorable functional outcome (modified Rankin Scale 3-6) in cardioembolic stroke …

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VSA012, a CFB-targeted siRNA, demonstrates a favorable safety profile and sustained efficacy in PNH patients: Interim Analysis from a Phase Ib Study

Neng Nie, Chen Yang, Junping Shi, Shunqing Wang et autres

Abstract Background: Paroxysmal nocturnal hemoglobinuria (PNH) is a rare acquired hemolytic disorder caused by somatic mutations in the PIG-A gene with significant unmet medical needs. Pathological activation of complement factor B (CFB), a critical regulatory component of the alternative complement pathway, contributes …

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DOES ADDITION OF LONGER-ACTING LOCAL ANAESTHETIC IMPROVE THE POSTOPERATIVE PAIN AFTER CARPAL TUNNEL RELEASE? A RANDOMIZED CONTROLLED TRIAL

Emily W. Chan, Leslie M. Sims, Chen Yang, Kristi Billard et autres

Carpal tunnel release (CTR) is a simple and effective treatment for carpal tunnel syndrome in patients who have failed conservative management. In Canada, this surgery is often performed in the ambulatory clinic under local anesthesia, with lidocaine (a short-acting agent) as the …

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DOES ADDITION OF LONGER-ACTING LOCAL ANAESTHETIC IMPROVE POSTOPERATIVE PAIN AFTER CARPAL TUNNEL RELEASE? A RANDOMIZED CONTROLLED TRIAL

Emily W. Chan, Leslie M. Sims, Chen Yang, Kristi Billard et autres

Carpal tunnel release (CTR) is a simple and effective treatment for carpal tunnel syndrome in patients who have failed conservative management. In Canada, this surgery is often performed in the ambulatory clinic under local anesthesia, with lidocaine (a short-acting agent) as the …

ca (code pays fourni par la source)

Factors Associated with Progression to Type 2 Diabetes among Women with Gestational Diabetes

Junxiu Liu, Chen Yang, Bian Liu, Ryung S. Kim et autres

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Recombinant Antithrombin Alleviated Pulmonary Injury and Inflammation in LPS-Induced ARDS by Inhibiting IL17a/NF-κB Signaling

Chen Yang, Cong Fu, Mengxue Wang, Junbo Zheng et autres

Background: Recombinant antithrombin (rAT) has been shown to protect lungs from ARDS and modulate immune responses, but its anti-inflammatory mechanisms remain unclear. This study aimed to explore the immunomodulatory effects and mechanisms of rAT in LPS-induced ARDS mice. Methods: ARDS mouse model …

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The Efficacy of Implementing Labor Analgesia Education via the WeChat Public Platform—A Randomized Controlled Study

Li‐Jun Ma, Yan Cheng, Hailian Liu, Wenjing Yang et autres

Background: Previous research has revealed that utilizing videos or images to educate primiparas about labor analgesia yields significantly superior results. WeChat supports various types of media, making it an ideal carrier for educational content. We have established a WeChat public account where …

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Single-cell transcriptomic analysis identifies downregulated phosphodiesterase 8B as a novel oncogene in IDH-mutant glioma

Zongze He, Peng Yu, Duo Wang, Chen Yang et autres

Introduction: Glioma, a prevalent and deadly brain tumor, is marked by significant cellular heterogeneity and metabolic alterations. However, the comprehensive cell-of-origin and metabolic landscape in high-grade (Glioblastoma Multiforme, WHO grade IV) and low-grade (Oligoastrocytoma, WHO grade II) gliomas remains elusive. Methods: In …

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The Median Effective Dose of Intrathecal Hyperbaric Bupivacaine for Cesarean Section at Moderately High-Altitude

Chen Yang, Wangjun Dong, Jianbo Luo, Mengzhao Ma et autres

Objective: Alterations in altitude can lead to an augmented requirement for local anesthesia among patients. Nevertheless, the necessity for an elevated dosage of local anesthetic for parturients at moderately high altitudes during spinal anesthesia for cesarean section remains uninvestigated. This up-down sequential …

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Comparison of the bispectral indices of patients receiving remimazolam and propofol for general anesthesia: a randomized crossover trial

Chen Yang, Jing Jiao, Yuyan Nie, Wenyu Shao et autres

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Interleukin-1β polarization in M1 macrophage mediates myocardial fibrosis in diabetes

Wenli Guo, Chen Yang, Jiawei Zou, Tingting Yu et autres

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Genetic and dietary determinants of insulin-like growth factor (igf)-1 and igf binding protein (bp)-3 levels among chinese women

Chen Yang, Lunan Liu, Lauren E. McCullough, Eric David Miller et autres

Background: Higher insulin-like growth factor (IGF)-1 and lower IGF binding protein (BP)-3 levels have been associated with higher commoncancer risk, including breast cancer. Dietary factors, genetic polymorphisms, and the combination of both may influence circulating IGF-1 and IGFBP-3 serum concentrations.Methods: From September …

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