Genetic and dietary determinants of insulin-like growth factor (igf)-1 and igf binding protein (bp)-3 levels among chinese women

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Background: Higher insulin-like growth factor (IGF)-1 and lower IGF binding protein (BP)-3 levels have been associated with higher commoncancer risk, including breast cancer. Dietary factors, genetic polymorphisms, and the combination of both may influence circulating IGF-1 and IGFBP-3 serum concentrations.Methods: From September 2011 to July 2012, we collected demographic, reproductive and dietary data on 143 women (> 40 years). We genotyped IGF-1 rs1520220 and IGFBP-3 rs2854744 and measured circulating IGF-1 and IGFBP-3 levels in serum. Covariance analyses were used to estimate the associations of serum levels of IGF-1 and IGFBP-3, and the molar ratio of IGF-1to IGFBP-3 with IGF-1 rsl 520220 and IGFBP-3 rs2854744 genotypes. We subsequently assessed the combined influence of genetics and diet (daily intake of protein, fat and soy isoflavones) on IGF-1 and IGFBP-3 levels.Results: Among women aged less than 50 years, circulating IGF-1 serum levels were significantly lower for those with CC genotype for IGF-1 rsl 520220 than levels for those with the GC or GG genotypes (in recessive model: P = 0.007).ln gene-diet analyses among these women, we found carrying CC genotype for IGF-1 rs1520220 and high soy isoflavone intake tend to be associated with lower circulating IGF-1 levels synthetically (P = 0.002). Women with GG or GC genotypes for IGF-1 rsl 520220 and with low intake of soy isoflavones had the highest levels of circulating IGF-1 (geometric mean [95% Cl]: 195 [37, 1021] μg/L). Comparatively, women with both the CC genotype and high soy intake had the lowest levels of circulating IGF-1 (geometric mean [95% Cl]: 120 [38,378] μg/L).Conclusions: IGF-1 serum levels are significantly lower among women with the CC genotype for IGF-1-rs1 520220. High soy isoflavone intake may interact with carrying CC genotype for IGF-1-rs1 520220 to lower women's serum IGF-1 levels more.

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