Wei Zhao

Kinetics of IgA Subtypes and Cytokines in Respiratory Secretions Following Immunization With COVID‐19 Mucosal Vaccine

Weixin Chen, Juan Li, Shuang Bai, Ao Zhang et autres

The COVID-19 pandemic highlights the need for mucosal vaccines inducing respiratory secretory IgA (sIgA), as traditional intramuscular vaccines primarily elicit systemic IgG with limited mucosal protection. This study systematically compared mucosal immune responses induced by two authorized COVID-19 mucosal vaccines: an orally …

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Long-term antibody trajectories after PPSV23 in elderly: Results from a 4-year follow-up study

Shanshan Zhou, Jian Wang, Min Lv, Wenwen Lan et autres

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The contributions of vaccination and natural infection to the production of neutralizing antibodies against the SARS-CoV-2 prototype strain and variants

Hui Xie, Junnan Zhang, Shuang Bai, Min Lv et autres

OBJECTIVES: To evaluate the neutralizing antibody (NAb) levels against the SARS-CoV-2 Omicron variants BF.7, BQ.1, BQ.1.1, XBB.1, and XBB.1.5 after vaccination and natural infection. METHODS: The NAbs against the different viral strains of 490 individuals with SARS-CoV-2 and 187 without SARS-CoV-2 in …

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Baseline Pneumococcal IgG Levels and Response to 23-Valent Pneumococcal Polysaccharide Vaccine among Adults from Beijing, China

Shanshan Zhou, Min Lv, Shuang Bai, Weixin Chen et autres

PURPOSE: and assess their impact on the assessment of vaccine immunogenicity. METHODS: We used a subset of serum samples from a randomized controlled trial. The blood of 584 healthy participants was collected on day 0 before and day 28 after the 23-valent …

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RT-RPA-PfAgo System: A Rapid, Sensitive, and Specific Multiplex Detection Method for Rice-Infecting Viruses

Yàn Liú, Wenqiang Xia, Wei Zhao, Peiying Hao et autres

The advancement in CRISPR-Cas biosensors has transmuted the detection of plant viruses owing to their rapid and higher sensitivity. However, false positives and restricted multiplexing capabilities are still the challenges faced by this technology, demanding the exploration of novel methodologies. In this …

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Prokaryotic Argonaute Proteins: A New Frontier in Point-of-Care Viral Diagnostics

Kai Sun, Yan Liu, Wei Zhao, Biao Ma et autres

The recent pandemic of SARS-CoV-2 has underscored the critical need for rapid and precise viral detection technologies. Point-of-care (POC) technologies, which offer immediate and accurate testing at or near the site of patient care, have become a cornerstone of modern medicine. Prokaryotic …

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Comparison of Immunogenicity of Alum and MF59-Like Adjuvant Inactivated SARS-CoV-2 Vaccines Against SARS-CoV-2 Variants in Elderly Mice

Shuang Bai, Yanli Kang, Weixin Chen, Hui Xie et autres

The constant emergence of variants of concern (VOCs) challenges the effectiveness of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines over time. This is most concerning in clinically vulnerable groups, such as older adults. This study aimed to determine whether the novel …

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The Contributions of Vaccination and Natural Infection to the Production of Neutralizing Antibodies Against the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Prototype Strain and Variants

Hui Xie, Junnan Zhang, Shuang Bai, Min Lv et autres

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