Shuang Bai

Kinetics of IgA Subtypes and Cytokines in Respiratory Secretions Following Immunization With COVID‐19 Mucosal Vaccine

Weixin Chen, Juan Li, Shuang Bai, Ao Zhang et autres

The COVID-19 pandemic highlights the need for mucosal vaccines inducing respiratory secretory IgA (sIgA), as traditional intramuscular vaccines primarily elicit systemic IgG with limited mucosal protection. This study systematically compared mucosal immune responses induced by two authorized COVID-19 mucosal vaccines: an orally …

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Modulation of the malignant behavior of tongue squamous cell carcinoma cells by matrix metallopeptidase 25 through the NF-κB pathway.

Shuang Bai, Shao-Kang Sun, Zhen-qi Xu, Ying‐Bin Yan

OBJECTIVE: Accumulating evidence has implicated matrix metalloproteinases (MMPs) in the progression of human cancers. Matrix metallopeptidase 25 (MMP25) is a membrane-type MMP whose role in tumorigenesis and cancer development is not well understood. Here, we investigated the functions of MMP25 in tongue …

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Immune memory reactivation and T cell dynamics following 12-month homologous CoronaVac booster: a longitudinal cohort study

Xinran Song, Weixin Chen, Shuang Bai, Min Lv et autres

Background: Inactivated COVID-19 vaccines exhibit more rapid declines in antibody levels than other vaccine platforms, likely owing to transient antigen exposure and limited germinal center persistence. Moreover, although homologous boosting effectively restores humoral immunity, concerns persist regarding potential T cell exhaustion with …

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Different patterns of antimicrobial non-susceptibility of the nasopharyngeal carriage of Streptococcus pneumoniae in areas with high and low levels of PCV13 coverage

Jian Wang, Wei Zhao, Shuang Bai, Ao Zhang et autres

INTRODUCTION: The impact of pneumococcal conjugate vaccines (PCVs) on antimicrobial resistance (AMR) in Streptococcus pneumoniae (Spn) among Chinese children remains inadequately characterized. Evidence is also limited on the interaction between vaccination coverage and regional disparities in AMR patterns. This study aims to …

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Clinical Relationship Between Serum ApoB , HER2, and Myocardial Ischemia Risk in Breast Cancer Patients

Yeyan Lei, Dongmei Li, Shuang Bai, Xing Ziggy Zeng et autres

ABSTRACT Background The risk factors and clinical prediction of cardiovascular comorbidities in patients with breast cancer have not been fully clarified. Aims This retrospective case–control study was designed to investigate the factors affecting myocardial ischemia occurrence in breast cancer patients. Methods and …

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Straightforward Synthesis of [2H2]-2-Acetyl-1-pyrroline Starting from α-Methyl N-Boc- l -Glutamate

Shuting Yin, Fangyao Su, Shuai Peng, Xixuan Zhao et autres

A straightforward and reliable three-step synthetic route for [ 2 H 2 ]-2-acetyl-1-pyrroline has been developed. In the first step, [ 2 H 2 ]-methyl N -Boc-prolinate was obtained in 68% yield through the reduction of α-methyl N -Boc- l -glutamate with …

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Temporomandibular joint capsule suspension for neocondyle stability in free fibular flap reconstruction of the mandibular condyle

Shuang Bai, Yao Yu, Wenbo Zhang, Yang Wang et autres

Objectives: This study evaluates the efficacy of a new temporomandibular joint (TMJ) capsule suspension technique for stabilizing the TMJ after free fibular flap reconstruction of the mandibular condyle. Patients and Methods: Patients undergoing the TMJ capsule suspension technique during free fibular flap …

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An improved synthesis of 2-acetyl-1-pyrroline via the Grignard reaction in the presence of Et3N/TMSCl

Shuting Yin, Fangyao Su, Jinlong Yu, Xixuan Zhao et autres

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Long-term antibody trajectories after PPSV23 in elderly: Results from a 4-year follow-up study

Shanshan Zhou, Jian Wang, Min Lv, Wenwen Lan et autres

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Immunogenicity and safety of different combinations involving a third booster dose of SARS-CoV-2 inactivated vaccine, inactivated quadrivalent influenza vaccine, and 23-valent pneumococcal polysaccharide vaccine in adults aged ≥60 years: a phase 4, randomized, open-label study

Shuang Bai, Shanshan Zhou, Junnan Zhang, Weixin Chen et autres

Background: Concomitant administration of COVID-19, influenza, and pneumococcal vaccines could reduce the burden on healthcare systems. However, the immunogenicity and safety of various combinations of a third booster dose of SARS-CoV-2 inactivated vaccine (CoronaVac), inactivated quadrivalent influenza vaccine (IIV4), and 23-valent pneumococcal …

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Clinical Relationship between Serum ApoB and Myocardial Ischemia Risk in Breast Cancer Patients

Dongmei Li, Qing Liu, Rongyuan Yang, Yeyan Lei et autres

Abstract The risk factors and clinical prediction of cardiovascular disease comorbidities in patients with breast cancer have not been fully clarified. We conducted this retrospective case-control study. The univariable and multivariable cox regression was used to screen the risk factors of cardiovascular …

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Prevalence and serotype distribution of nasopharyngeal carriage of Streptococcus pneumoniae among healthy children under 5 years of age in Hainan Province, China

Jian Wang, Qiu Li, Shuang Bai, Wei Zhao et autres

BACKGROUND: The thirteen-valent pneumococcal conjugate vaccine (PCV13) is not included in the national immunization program and is administered voluntarily with informed consent in China. In preparation for assessing the impact of pilot introduction in Hainan Province, we conducted a carriage study among …

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