Yongfu Wang

Short-Interval, Low-Dose versus High-Dose Cyclophosphamide for Menstrual Disorders in Systemic Lupus Erythematosus: A Multicenter Real-World Study

Miao Shao, Chenglin Tang, Gesang Quzhen, Zeng Luo et autres

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Retraction notice to ‘Thrombus-targeted nanoparticles for thrombin-triggered thrombolysis and local inflammatory microenvironment regulation’ [Journal of Controlled Release 339 (2021) 195–207]

Hailong Zhang, Hongyan Qu, Qingqing He, Linyu Gao et autres

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Targeting oncogenic NTSR1 with liensinine reprograms Gq-mediated signaling to suppress lung adenocarcinoma

Yongfu Wang, Wei Liu, Pengzhuo Tao, Changmin Liu et autres

BACKGROUND: Lung adenocarcinoma (LUAD) is a leading cause of cancer death. Neurotensin receptor 1 (NTSR1), a G protein-coupled receptor, is overexpressed in LUAD and linked to poor prognosis, but its therapeutic potential is underexplored. METHODS: This study combined multi-database bioinformatics to systematically …

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Identification and Functional Validation of PTH2R as a Therapeutic Target in Lung Adenocarcinoma

Changmin Liu, Yongfu Wang, Wei Liu, Yizhen Yuan et autres

Background: One of the main causes of cancer-related mortality globally is lung adenocarcinoma (LUAD), necessitating the development of novel therapeutic targets. The parathyroid hormone type 2 receptor (PTH2R) exhibits differential expression across multiple cancers, yet its role in LUAD remains unclear. Methods: …

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Targeting NPY5R—A Member of the NPY Receptor Family: Pharmacological and Transcriptomic Mechanisms of the Euphorbia Factor L2 Against Lung Adenocarcinoma

Pengzhuo Tao, Wei Liu, Yongfu Wang, Yajing Xue et autres

Background: Advanced lung adenocarcinoma (LUAD) is the leading cause of cancer-related deaths, with existing treatments hampered by drug resistance. This underscores the urgent need to identify novel therapeutic targets. The role of neuropeptide Y (NPY) receptors in LUAD remains unclear, and this …

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Expression Profile of Metabotropic Glutamate Receptors in Lung Adenocarcinoma: GRM5 and Validation of Its Targeting Drug Cinchonine

Yajing Xue, Wei Liu, Yongfu Wang, Pengzhuo Tao et autres

The incidence and mortality rates of lung adenocarcinoma (LUAD) continue to rise, highlighting an urgent need for novel therapeutic targets. In this study, bioinformatics analysis revealed that members of the metabotropic glutamate receptor (mGluR) family are significantly correlated with the expression profile, …

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Tangeretin Suppresses LUAD via SSTR4 Downregulation: Integrated Bioinformatics and Functional Validation

Yizhen Yuan, Yongfu Wang, Wei Liu, Changmin Liu et autres

Lung adenocarcinoma (LUAD) remains the leading cause of cancer-related mortality worldwide, highlighting the urgent need for novel therapeutic targets. While the role of the somatostatin receptor (SSTR) family is well established in neuroendocrine tumors, their expression patterns, clinical significance, and therapeutic potential …

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Analysis of GSDMD-N abnormality promoting neutrophil NETs mediated RA disease through NLRP3-dependent pathway

Yali Sang, Huiyang Liu, Bingle Li, Lingyan Zhu et autres

Introduction: Rheumatoid arthritis (RA) is characterized by persistent synovitis and progressive joint damage. Mounting evidence implicates neutrophil extracellular traps (NETs) formation (NETosis) in RA pathogenesis, yet the upstream regulatory nodes remain incompletely defined. We aimed to elucidate the role of the NLRP3 …

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Comprehensive Analysis of the UGT Gene Superfamily in Spodoptera frugiperda

Yang Liu, Minghui Guan, Kunliang Zou, Tonghan Wang et autres

UDP-glycosyltransferases (UGTs) are widely distributed enzymes in living organisms that catalyze the transfer of glycosyl groups from donor molecules to acceptor molecules’ glycoside ligands. These enzymes are pivotal for detoxifying and eliminating both endogenous and exogenous toxic substances in insects. In this …

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Molecular Cytogenetic Identification of Wheat– Aegilops geniculata Derivative Line with Resistance to Powdery Mildew Encoded on Chromosome 6U g

Yongfu Wang, Yongfu Wang, Yibo Shao, Caizheng Wang et autres

Aegilops geniculata Roth is a valuable donor for improving common wheat (Triticum aestivum) because of their close relationship. In this study, W181009 was identified as a BC 1 F 12 progeny resulting from the cross between ‘Chinese Spring’ and Ae. geniculata SY159. …

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2A-biohydrogels accelerate diabetic wound healing by promoting M2 macrophage polarization and functionalized mitochondrial transfer to endothelial cells

Hao Wang, Min Zhou, Yifei Shen, Xingbo Wu et autres

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The KDM5A/HOXA5 axis regulates osteosarcoma progression via activating the Wnt/β-catenin pathway

Yi Luo, Youzhi He, Yuxia Xu, Yongfu Wang et autres

As an oncogenic driver, lysine-specific demethylase 5A (KDM5A) participates in regulating numerous tumor progression-related processes. Moreover, KDM5A functions as a histone demethylase, modulating the expression levels of its target genes by adjusting methylation levels. However, the underlying molecular mechanism of KDM5A in …

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