Kun Wang

250 Umbilical cord blood-derived CD19-CAR-T cells exhibit effective anti-tumor activity and demonstrate a low profile of pro-inflammatory and allograft rejection

Salim Bougarn, Mohammed Toufiq, Mohammed Elanbari, Shana Sunny Jacob et autres

Background The aim of this study was to validate the manufacturing of CD19-CAR-T cells generated from umbilical cord blood (UCB) and perform the comprehensive multi-omics and functional characterization.Methods T cells were isolated from umbilical cord blood (UBCs; N=20) and activated in vitro …

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Abstract 6277: A time-series mouse model identifies an early post-treatment effective liquid biomarker of ICB response in human head and neck cancer

Binbin Wang, Robert Saddawi‐Konefka, Lauren M. Clubb, Shiqi Tang et autres

Abstract Background & Approach: Immune checkpoint blockade (ICB) therapy has shown promise for head and neck squamous cell carcinoma (HNSCC); however, response rates remain limited, with only a subset of patients exhibiting significant clinical benefits. Identifying non-invasive liquid biomarkers to predict ICB …

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The integrative genomic and functional immunological analyses of colorectal cancer initiating cells to modulate stemness properties and the susceptibility to immune responses

Issam Tout, Salim Bougarn, Mohammed Toufiq, Neha Gopinath et autres

BACKGROUND: Colorectal cancer (CRC) initiating cells (CICs) possess self-renewal capabilities and are pivotal in tumor recurrence and resistance to conventional therapies, including immunotherapy. The mechanisms underlying their interaction with immune cells remain unclear. METHODS: We conducted a multi-omics analysis-encompassing DNA methylation, total …

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Abstract A004: RNA splicing alterations in the development of acquired MAPKi resistance in melanoma

Sumit Mukherjee, Arashdeep Singh, Hyunjeong Joo, Sumeet Patiyal et autres

Abstract The standard treatment for melanoma with a BRAF mutation involves Mitogen-Activated Protein Kinase inhibitors (MAPKi), which target the aberrant MAPK signaling pathway. Although patients initially respond well to this therapy, many develop acquired resistance over time. This resistance can be attributed …

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Abstract C173: Negative selection of ligand-receptor interactions mediating lymphocyte infiltration confers melanoma resistance to Immune Checkpoint Blockade therapy by turning hot tumors to cold

Sahil Sahni, Kun Wang, Binbin Wang, Saugato Rahman Dhruba et autres

Abstract Immune checkpoint blockade (ICB) is a promising cancer therapy; however, response rates remain less than desired (less than ~40%) and resistance often develops. To learn more about ICB resistance mechanisms, we developed IRIS (Immunotherapy Resistance cell-cell Interaction Scanner), a machine learning …

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Sphingolipids in Childhood Asthma and Obesity (SOAP Study): A Protocol of a Cross-Sectional Study

Belavendra Antonisamy, Harshita Shailesh, Yahya Hani, Lina Ahmed et autres

Asthma and obesity are two of the most common chronic conditions in children and adolescents. There is increasing evidence that sphingolipid metabolism is altered in childhood asthma and is linked to airway hyperreactivity. Dysregulated sphingolipid metabolism is also reported in obesity. However, …

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1306 Negative selection of ligand-receptor interactions mediating lymphocyte infiltration confers melanoma resistance to immune checkpoint blockade therapy by turning hot tumors to cold

Sahil Sahni, Kun Wang, Binbin Wang, Saugato Rahman Dhruba et autres

Background Immune checkpoint blockade (ICB) is a promising cancer therapy; however, response rates remain less than desired (less than ~40%) and resistance often develops. Methods To learn more about ICB resistance mechanisms, we developed IRIS (Immunotherapy Resistance cell-cell Interaction Scanner), a machine …

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An integrated tumor, immune and microbiome atlas of colon cancer

Jessica P Roelands, Peter J.K. Kuppen, Eiman I. Ahmed, Raghvendra Mall et autres

The lack of multi-omics cancer datasets with extensive follow-up information hinders the identification of accurate biomarkers of clinical outcome. In this cohort study, we performed comprehensive genomic analyses on fresh-frozen samples from 348 patients affected by primary colon cancer, encompassing RNA, whole-exome, …

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Supplementary Data AC-ICAM

Jessica P Roelands, Peter J.K. Kuppen, Gianni Monaco, Parul Sing et autres

Supplementary data for the AC-ICAM manuscript.

Transcriptomic Profiling of Plasma Extracellular Vesicles Enables Reliable Annotation of the Cancer-specific Transcriptome and Molecular Subtype

Vahid Bahrambeigi, Jaewon James Lee, Vittorio Branchi, Kimal Rajapakshe et autres

Abstract Longitudinal monitoring of patients with advanced cancers is crucial to evaluate both disease burden and treatment response. Current liquid biopsy approaches mostly rely on the detection of DNA-based biomarkers. However, plasma RNA analysis can unleash tremendous opportunities for tumor state interrogation …

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Datasets for TEEBot

Basu Mahashweta, Kun Wang, Ruppin Eytan, Hannenhalli Sridhar

Datasets for TEEBot (tissue specific gene expression prediction from whole blood transcriptome) Scripts available on github: https://github.com/mbasugit/Imputation

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Datasets for TEEBot

Basu Mahashweta, Kun Wang, Ruppin Eytan, Hannenhalli Sridhar

Datasets for TEEBot (tissue specific gene expression prediction from whole blood transcriptome) Scripts available on github: https://github.com/mbasugit/Imputation

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