Aihua Wu

Kir5.1-Modulated Potassium Flux Stimulates an Anabolic Kidney Phenotype

Masakí Inoue, Andrew Scott Terker, Eric J. Delpire, Aihua Wu

Background: Maintaining potassium (K) homeostasis imposes a significant metabolic burden on the kidney, requiring constant energy to support electrolyte transport and prevent K imbalance. Reduced dietary K triggers nephron remodeling and enhanced proximal tubule sodium (Na) reabsorption—adaptations requiring metabolic reprogramming. The proximal …

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P3.12.74 IMM2510, an Anti-PD-L1/VEGF Bispecific Antibody Fusion Protein for Advanced IO-treated SQ-NSCLC: A Phase I Study

Patrick T. Wang, Yi Zhang, Aihua Wu, Shuai Gao et autres

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Kir5.1-modulated potassium flux stimulates an anabolic kidney phenotype

Aihua Wu, Masa-Ki Inoue, Clinton M. Hasenour, Juan Pablo Arroyo et autres

channels to modulate cell physiology and metabolism.

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1857-LB: GLP-1 Receptor Agonist and GLP-1GIP Dual Agonist in Diabetic Kidney Disease

Aihua Wu

Introduction and Objective: Diabetic nephropathy (DN) develops in roughly 30% of diabetic patients & is the leading cause of chronic kidney disease. Characterized by irreversible deterioration of renal function, DN lacks effective therapeutic approaches for treatment. This study explores the renoprotective effects …

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Plasma Potassium Negatively Correlates With Sodium Chloride Cotransporter Abundance and Phosphorylation in Urinary Extracellular Vesicles From Patients With Chronic Kidney Disease

Aihua Wu, Martin J. Wolley, David Alan Vesey, Andrew Scott Terker et autres

ABSTRACT Aim Using urinary extracellular vesicles (uEVs), we have demonstrated the functional ‘renal‐K switch’ mechanism (the WNK‐SPAK‐NCC pathway) in both healthy subjects and those with primary aldosteronism. The close relationship between blood pressure and CKD has led to the hypothesis that high …

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Macrophage SPAK deletion limits a low potassium-induced kidney inflammatory program

Aihua Wu, Fabian M Bock, Juan Pablo Arroyo, Eric J. Delpire et autres

Global Ste20p-related proline alanine-rich kinase (SPAK) deletion protects against harmful kidney effects of dietary K+ deficiency. Exposure to low K+ conditions increases SPAK phosphorylation and induces SPAK to adopt a punctate staining pattern. Macrophage-specific deletion of SPAK confers protection to low K+-induced …

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Heat Transfer Characteristics between Microparticles and Fluids in a Microchannel

Zhiguo Wu, Yifeng Guo, Dan Shao, Zhibin Wang et autres

Microparticle suspensions are prevalent in both natural and industrial environments, playing a crucial role in various processes. The heat transfer characteristics between particles and fluids are critical to many of these processes. This study employs the Arbitrary Lagrangian-Eulerian finite element method to …

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Plasma Potassium Negatively Correlates with Sodium-Chloride Cotransporter (NCC) Abundance and Phosphorylation in Urinary Extracellular Vesicles (uEVs) from Patients with CKD

Aihua Wu, Paul A. Welling, Andrew Scott Terker

Background: Hypertension is a leading cause of CKD. Low potassium diet is often advised in moderate to severe CKD. Emerging data now suggest that higher dietary potassium may be beneficial in these patients, but the underlying mechanism is unclear. Using uEVs we …

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Randomized Trial on the Effect of Oral Potassium Chloride Supplementation on the Thiazide-Sensitive Sodium Chloride Cotransporter in Healthy Adults

Aihua Wu, Martin J. Wolley, Hannah L. Mayr, Diane Cowley et autres

Introduction The putative "renal-K switch" mechanism links dietary potassium intake with sodium retention and involves activation of the sodium chloride (NaCl) cotransporter (NCC) in the distal convoluted tubule in response to low potassium intake, and suppression in response to high potassium intake. …

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PS-BPC10-7: EFFECT OF ORAL POTASSIUM CHLORIDE SUPPLEMENTATION ON THE THIAZIDE-SENSITIVE SODIUM CHLORIDE COTRANSPORTER (NCC) IN HEALTHY HUMANS: A RANDOMISED CROSSOVER TRIAL

Aihua Wu, Martin J. Wolley, Hannah L. Mayr, Diane Cowley et autres

Objective: The putative “renal-K+ switch’’ mechanism links low K + intake with Na+-dependent Na+ retention and involves activation of NCC in the distal convoluted tubule in response to low K+ intake and suppression in response to high K+ intake. This study used …

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Using human urinary extracellular vesicles to study physiological and pathophysiological states and regulation of the sodium chloride cotransporter

Aihua Wu, Martin J. Wolley, Robert A. Fenton, Michael Stowasser

The thiazide-sensitive sodium chloride cotransporter (NCC), expressed in the renal distal convoluted tubule, plays a major role in Na + , Cl - and K + homeostasis and blood pressure as exemplified by the symptoms of patients with non-functional NCC and Gitelman …

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In Primary Aldosteronism Acute Potassium Chloride Supplementation Suppresses Abundance and Phosphorylation of the Sodium-Chloride Cotransporter

Aihua Wu, Martin J. Wolley, Alexandra L. Matthews, Diane Cowley et autres

Key Points Potassium chloride intake induced a reduction in sodium-chloride cotransporter (NCC) and phosphorylated NCC in urinary extracellular vesicles from patients with primary aldosteronism during a significantly raised level of endogenous aldosterone. Low plasma potassium (secondary to aldosterone excess) may dominate in …

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