Jian Xu

Hidden genetic diversity in 320 nearly-complete East Asian genome assemblies

Dongya Wu, Chentao Yang, Quanyu Chen, Mingyu Suo et autres

East Asian populations, representing over 20% of the global population, remain critically underrepresented in human genomic studies, limiting our understanding of population-stratified genetic variation and its implications for health and disease. Here we present the first phase of the Asian Pan-Genome project …

cn, us, Botswana, pk, me (code pays fourni par la source)

Denoising‐Assisted Rapid Multiphoton Imaging for Analysing Traumatic Penumbra Microenvironment in Rat Brain

Pan Guo, Le Chen, Shanghai Jiang, Li Ai et autres

Accurate identification of the traumatic penumbra (TP) is essential for understanding secondary injury after traumatic brain injury. However, conventional imaging cannot capture microenvironmental alterations at subcellular resolution. In this study, denoising-assisted multiphoton microscopy (MPM) was used to investigate the microstructural features of …

cn (code pays fourni par la source)

(+)-Strebloside induces Non-Hodgkin lymphoma cell death through the STEAP3-Mediated Ferroptosis and MAPK pathway

Yu Zhao, Jing Cai, Ying Yang, Dongmei Zhang et autres

cn (code pays fourni par la source)

Metabolic Interplay in Acute Lung Injury: PARK7 Integrates FADS1/2‐Dependent PUFA Metabolism and H3K14 Lactylation to Attenuate Endothelial Ferroptosis and Dysfunction

Jian Xu, Yuhan Wang, Weiqi Mao, Tianchang Wei et autres

Acute respiratory distress syndrome (ARDS) is a severe clinical condition characterized by widespread inflammation and fluid accumulation in the lungs. Endothelial cell (EC) metabolic changes in acute lung injury (ALI) and their relationship to injury remain unclear. Transcriptomic and lipidomic analyses revealed …

cn (code pays fourni par la source)

Ciliated cells promote high infectious potential of influenza A virus through the efficient intracellular activation of hemagglutinin

Zijian Guo, Victoria Banas, Yuanyuan He, Elizabeth Weiland et autres

ABSTRACT Influenza viruses utilize host proteases to activate the viral fusion protein, hemagglutinin (HA), into its fusion-competent form. Although proteolytic activation of HA is essential for virus replication, the cell-type dependence of HA activation within the airway epithelium and the subcellular location(s) …

us (code pays fourni par la source)

Targeting PARK7: Sodium 4-Phenylbutyrate shields endothelial cells from oxidative stress and GSDME-mediated Pyroptosis in acute lung injury

Jian Xu, Tianchang Wei, Yuhan Wang, Cuiping Zhang et autres

The mechanisms of endothelial cell injury in acute lung injury (ALI) remain unclear, and effective interventional strategies targeting endothelial cells are limited. Sodium 4-phenylbutyrate (Na-PBA), a histone deacetylase inhibitor, can potentially reduce oxidative damage. Its effects on pyroptosis and its relationship with …

cn (code pays fourni par la source)

Role of intraflagellar transport protein IFT140 in the formation and function of motile cilia in mammals

Yi Tian Yap, Jiehong Pan, Jian Xu, Shuo Yuan et autres

Cilia are microtubular structures extending from the surface of most mammalian cells. They can be categorized as motile cilia and primary sensory cilia. Both types possess intraflagellar transport (IFT) machinery, composed of unique protein complexes that travel along the microtubules to deliver …

us, cn, ph, fr (code pays fourni par la source)

Novel janus kinase 3 inhibitor ritlecitinib suppresses T and B cell responses to prevent acute cardiac allograft rejection in mice

Rumin Liu, Xiaoyi Shi, Wenli Zeng, Yuchen Wang et autres

cn (code pays fourni par la source)

Cas9 Mouse Model of Skull Base Meningioma Driven by Combinational Gene Inactivation in Meningeal Cells

Hailiang Tang, Feng Xu, Dan Sun, Lingyang Hua et autres

ABSTRACT Introduction Neurofibromatosis type 2 ( Nf2 ) gene inactivation is common in sporadic and Nf2 ‐related meningioma. There is currently scant literature describing the development of an intracranial meningioma model in animals. Given the role of Nf2 and other gene inactivation …

cn (code pays fourni par la source)

KMT2D missense mutation identifies urothelial carcinoma subtype with distinct genomic characteristics and clinical outcomes

Zhisheng Xu, Zhen Liu, Zhiqiang Wang, Kairui Jin et autres

Gender disparities in clinical outcomes of urothelial carcinoma linked to X chromosome gene KDM6A mutation

Zhaofei Liu, Kairui Jin, Zhanqi Wang, Yong Zhu et autres

Neuraminidase Activity Modulates Cellular Coinfection during Influenza A Virus Multicycle Growth

Zijian Guo, Yuanyuan He, Jian Xu, Ananya Benegal et autres

Influenza virus populations are comprised of particles that are mostly noninfectious or only partly infectious. As a result, multiple virions are frequently needed for influenza to infect a new cell. Despite its importance in viral spread, mechanisms that control cellular coinfection are …

us (code pays fourni par la source)