Neuraminidase Activity Modulates Cellular Coinfection during Influenza A Virus Multicycle Growth

Le résumé fourni par la source

Influenza virus populations are comprised of particles that are mostly noninfectious or only partly infectious. As a result, multiple virions are frequently needed for influenza to infect a new cell. Despite its importance in viral spread, mechanisms that control cellular coinfection are not well established. By tracking the local spread of virions from single infected cells, we identify an important role for the viral receptor-destroying enzyme neuraminidase in modulating the degree of coinfection that occurs during multicycle virus growth. We find that decreasing neuraminidase activity facilitates viral attachment to neighboring cells and increases the infectious load that these cells receive. These results identify a genetic mechanism through which the frequency of coinfection may be tuned, with implications for virus evolution.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.