Pawan Kumar

An Unusual Case of Recurrent Pleural Effusion in a Child

M. M. Harjai, R Kale, Pawan Kumar, Ramesh Holla

Traumatic pancreatitis in children rarely results in the development of a recalcitrant pleural effusion, secondary to a connection between the pleural cavity and the pancreas. This child presented with predominantly respiratory symptoms of an underlying abdominal condition. Patients with large, recurring pleural …

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Letter to the Editor concerning “Comparable long term pain and disability outcomes following decompression alone versus decompression with fusion in lumbar spinal stenosis patients with high signal facet joints” by GJM Cameron, et al. (Eur Spine J [2025]; doi: 10.1007/s00586-025-09065-8)

Vishal Kumar, Pawan Kumar, Ankit Dadra

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Letter to the editor concerning “Diagnostic accuracy of the compression overload test versus straight leg Raise test in detecting lumbar disc herniation: an MRI-Validated Cross-Sectional study” by M. Madhesh, et al. (Eur spine J [2025]; doi: 10.1007/s00586-025-09164-6)

Vishal Kumar, Pawan Kumar, Ankit Dadra

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Effects of increased heart rates on the hemodynamic features and arterial stress in a realistic left anterior descending coronary artery model of a young human with different degrees of stenosis

Pawan Kumar, Siddharth Durgaprasad Sharma, Prasanta Kumar Das, Somnath Roy

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Synthesis, Characterization, Biological Activity And Molecular Docking Studies Of 1,2,4-Triazole Linked Quinoline Derivatives

Gopinath Sreelatha, Pawan Kumar, E. Balraju, Aliya Begum

With the use of cyclization and Schiff's base reactions, a new group of 1,2,4-triazole-linked quinoline derivatives (3a – 3j) was effectively synthesized with yields ranging from moderate to excellent. The potential anticancer, antibacterial, and anthelmintic medicinal properties of these compounds were subsequently …

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Exceptional Seizure-Like Presentation of Torsades De Pointes

Kanchan Kanchan, Ahmed A. M. Mohamed, Pawan Kumar

We present a rare case of a 40-year-old male who experienced a seizure-like episode, later diagnosed as torsades de pointes (TDP), following an R-on-T phenomenon feature on ECG. This case underscores the importance of considering cardiac arrhythmias in the differential diagnosis of …

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DESIGN, SYNTHESIS, CHARACTERISATION AND STRUCTURAL INSIGHTS INTO THE DRUG-LIKENESS OF SUBSTITUTED CHALCONES

E. Balraju, Pawan Kumar, Bhogadi Manogna Santhoshi, Gopinath Sreelatha et autres

UGC-CARE, UGC CARE, UGC CARE list, ugc approved journal, UGC CARE, UGC CARE list, UGC CARE list of Journal, UGCCARE, care journal list, UGC-CARE list, New UGC-CARE Reference List, New ugc care journal list, Research Journal, Research Journal Publication, Research Paper, Low …

Improved In Vivo Metabolic Stability and Silencing Efficacy of siRNAs with Phosphorothioate Linkage-Free, GalNAc-Conjugated Sense Strands Containing Morpholino-LNA Modifications

Dhrubajyoti Datta, Pawan Kumar, Jayanta Kr. Kundu, June Qin et autres

To ensure specificity, loading of the sense strand of small interfering RNAs (siRNAs) into RISC must be inhibited. We show here that siRNAs with 5'- and 6'-morpholino LNA residues or 6'-OH-LNA at the 5' terminus of a fully phosphodiester sense strand resulted …

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CARDIAC TAMPONADE MASQUERADING AS ST ELEVATION MYOCARDIAL INFARCTION: A CASE REPORT

M.K. Sidhu, Margaret Liu, Pawan Kumar, Ahmad Mohammad Hamdan et autres

Modern Therapeutic Approaches of Neurological Disorders: Current Insights and Future Perspectives

Debalina Saha, Bhawna Paliwal, Mahasweta Mandal, Siddhartha Dan et autres

This chapter conveys information about different neurological disorders and how they are being treated in the past years. It also considers the new ways that are being adapted to treat those 384 diseases, such as the nose-to-brain technique. The introduction confers information …

Quantum mechanical parameters-based study of aryl sulphonamides as 5-HT6 serotonin ligand using DFT methods

Pawan Kumar, PRITI SINGH, Rajnish Kumar Singh, MOHD. ADIL KHAN

In the present work, quantum mechanical descriptors have been used for the development of quantitative structure activity relationship (QSAR) models for the thirty-two derivatives of aryl sulphonamide and sulfone based 5-HT6 antagonists. Among several classes of serotonin 5-HT6 receptor ligands, aryl sulphonamides …

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Conformation matters: siRNAs with antisense strands with 5′-( E )-vinyl-phosphonate-α- l -LNA elicit stronger RNAi-mediated gene silencing than those with 5′-( E )-vinyl-phosphonate-LNA

Dhrubajyoti Datta, Pawan Kumar, Soham Mandal, Monika Krampert et autres

RNAi-mediated gene silencing is more efficient when the antisense strand of the siRNA is modified at 5′ end with a 5′-vinyl-phosphonate carrying nucleotide that adopts a C3′- exo (south) conformation than a C3′- endo (north) pucker.

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