Edward Kim

Towards the clinical translation of a novel autophagy inhibitor: Bisaminoquinoline derivative nanoparticles

Sohaib Mahri, Menghuan Tang, Qiufang Zong, Edward Kim et autres

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A pragmatic phase 2 trial of locally ablative therapy in oligo-progressive genitourinary (GU) tumors: LAYOVER

Amisha Singh, P. N. Lara, Nikhil N. Chatakondi, Kathleen Legarza et autres

TPS291 Background: Oligoprogressive disease (OPD) may represent an opportunity for locally ablative therapies to provide disease control in patients otherwise responding to systemic therapy. In GU malignancies, retrospective data suggest that ablating resistant clones in OPD sites with metastasis-directed therapies (MDT) such …

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DART/SWOG/NCI phase II anti-CTLA-4/PD-1 trial: clear cell carcinomas of ovary, endometrium, cervix

Young Kwang Chae, Megan Othus, Sandip Pravin Patel, Floortje J. Backes et autres

BACKGROUND: Dual anti-CTLA-4/PD-1 inhibitors show efficacy in numerous malignancies. We are the first to report on the efficacy of ipilimumab-nivolumab immunotherapy in a dedicated cohort of patients with gynecologic clear cell carcinomas (CCCs), which are rare, aggressive cancers. METHODS: DART is a …

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${{\mathcal{H}}_{\infty} }$ Performance Analysis for Almost Periodic Piecewise Linear Systems With Application to Roll-to-Roll Manufacturing Control

Edward Kim, Enrique Isaza Velásquez, Wei Li, Dongmei Chen

An almost periodic piecewise linear system (APPLS) is a type of piecewise linear system where the system cyclically switches between different modes, each with an uncertain but bounded dwell-time. Process regulation, especially disturbance rejection, is critical to the performance of these advanced …

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${{\protect\mathcal{H}}_{\infty} }$ Performance Analysis for Almost Periodic Piecewise Linear Systems With Application to Roll-to-Roll Manufacturing Control

Christopher Scott Martin, Edward Kim, Enrique Isaza Velásquez, Wei Li et autres

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NCI 10211: a phase II, single-arm study of berzosertib in combination with irinotecan in patients with advanced TP53 mutant gastroesophageal cancer

Margaret C. Wheless, Shannon Stockton, Heloisa P. Soares, Farshid Dayyani et autres

BACKGROUND: Mutations in TP53 are common in gastroesophageal cancer and portend a poor prognosis. Tumor cells with TP53 mutations increasingly rely on ataxia-telangiectasia and Rad3-related (ATR) protein to respond to and repair DNA damage induced by cytotoxic chemotherapy. We aimed to assess …

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705 Immunosuppressive CD14 + monocytes are enriched in patients with hepatocellular carcinoma and worse liver function (child-pugh B) and are associated with unfavorable immunotherapy outcomes

Zenghua Fan, Bridget P. Keenan, Bryan Le, Quincy Harris et autres

Background Immune checkpoint inhibition (ICI) and anti-angiogenic therapies including multikinase inhibitors are active in advanced hepatocellular carcinoma (HCC), though only a subset of patients achieved durable responses. Combined inhibition of myelosuppressive immune cells and angiogenesis in the tumor microenvironment may reduce primary …

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268 Regional B7-H3 CAR cell therapy and liver-directed radiation for pancreatic cancer liver metastases

Megan Purl, Alexandria Shick, Cyrus J. Sholevar, Tasneem Mukarrama et autres

Background Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease characterized by early liver metastases. Chimeric antigen receptor (CAR) modified cells (T and NK) have been largely unsuccessful in PDAC and other solid tumors, despite success in hematologic malignancies. Limitations in homing and …

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Phase 1 clinical trial of the ataxia telangiectasia and Rad3‐related inhibitor berzosertib with irinotecan in patients with advanced solid tumors (ETCTN 9938)

Liza C. Villaruz, Jingxiao Jin, Hong Wang, James J. Lee et autres

ABSTRACT Background Ataxia telangiectasia and Rad3‐related (ATR) inhibition with berzosertib potentiates the efficacy of irinotecan in preclinical models. The authors hypothesize that this combination is well tolerated, modulates the DNA damage response to irinotecan, and is associated with clinical activity in advanced …

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Areas of Uncertainty in Pancreatic Cancer Surveillance: A Survey Across the International Pancreatic Cancer Early Detection (PRECEDE) Consortium

Anjeli Manam, Jessica N. Everett, Sigurdís Haraldsdóttir, Phil A. Hart et autres

PURPOSE Pancreatic cancer (PC) surveillance is increasingly recommended for high-risk individuals, but there are remaining areas of uncertainty that are not consistently addressed by guidelines contributing to heterogeneity in clinical practice. Herein, we compare PC surveillance practices across sites in the international …

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Abstract A074: A novel nano-formulated taxoid (RP-001) enhances T-cell infiltration and prolongs survival in preclinical models of pancreatic ductal adenocarcinoma

Laura Musumeci, Irèna Krga, Lizbeth Flores, Allison Ehrlich et autres

Abstract Pancreatic ductal adenocarcinoma (PDA) is a highly lethal malignancy with a poor prognosis. Current therapies, including immunotherapy, have demonstrated limited efficacy, highlighting the urgent need for novel therapeutic agents. This study aimed to evaluate the therapeutic potential of a novel taxoid …

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Experience of patients with HIV and squamous cell carcinoma of the anal canal (SCAC) treated with retifanlimab.

Jean‐Philippe Spano, Jaume Capdevila, Frank Van Fraeyenhove, Sara Lonardi et autres

3521 Background: People living with HIV (PLHIV) usually have more advanced cancer at diagnosis and a higher cancer-related mortality, posing a significant burden on health care. However, clinical studies often exclude cancer patients with HIV, thereby limiting access to therapies for this …

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