Dongxiao Li

Progesterone reprograms γδT cell metabolism and attenuates cytotoxicity to ameliorate recurrent spontaneous abortion

Shuting Gu, Yanhong Yang, Dongxiao Li, Yanzheng Gu et autres

BACKGROUND: Progesterone is essential for pregnancy and immune regulation. Excessive γδT cell cytotoxicity has been implicated in recurrent spontaneous abortion. How progesterone regulates γδT cell function through metabolic pathways remains unclear. METHODS: Normal pregnancy and abortion-prone murine models were administered the progesterone …

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Association of Blood Cadmium and Lead with the Risk of Diabetic Foot Ulcers: The Suppression Effect of Hemoglobin (NHANES 1999-2004)

Yi Yang, Zunwang Li, Yunyi Chang, Dongxiao Li et autres

BackgroundDiabetic foot ulcer (DFU) is one of the most severe complications of diabetes, with hemoglobin (HGB) and inflammatory markers playing pivotal roles in its pathogenesis. However,the modifying effects of interactions between blood cadmium (Cd) and lead (Pb) exposure and these biological indicators …

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Computational prediction of potential aggravating mechanisms of polyethylene terephthalate microplastics in diabetic foot ulcers: An integrated in silico approach combining network toxicology, bioinformatics, machine learning, and molecular dynamics simulations

Dongxiao Li, Zhanhua Ma, Zunwang Li, Zhihong Fu et autres

The increasing incidence of diabetic foot ulcer (DFU) and growing recognition of environmental pollutants have highlighted polyethylene terephthalate microplastics (PET-MP) as a potential metabolic disease trigger. However, the molecular mechanisms linking PET-MP to DFU remain unclear. This study employed integrated network toxicology …

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Clinical and genetic characteristics of and diagnostic insights on KBG syndrome in Chinese patients: a retrospective study and literature review

Shiqi Wang, Shengnan Wu, Haiyan Wei, Nan Lv et autres

BACKGROUND: Most published cohorts of individuals with KBG are Caucasian which limits the understanding of the genetic diversity and clinical presentation across ethnicities. Herein, we report Chinese patients with KBGS, summarise their clinical and genetic characteristics, and compare their characteristics with those …

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Application of the combined PBL-CBL teaching method of anaphylactic shock prevention and care in the fundamental nursing course

Xin Jiang, Yiqing Hui, Chuan Tong, Dongxiao Li et autres

INTRODUCTION: In recent decades, numerous studies have explored Problem-based Learning (PBL) or Case-based Learning (CBL) alone, but few have investigated their combination. Fundamental nursing is a core course for nursing undergraduates, and anaphylactic shock (a life-threatening clinical emergency) is a key teaching …

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Tailorable Repellent Surface with Reconfigurable Mushroom‐Like Microstructures by Swelling‐Assisted Socket Molding

Boxi Sun, Liwen Xu, Yuxuan Sun, Xingxiang Li et autres

Abstract Bionic mushroom‐like microstructures inspired by springtails cuticle have great research value for advanced superhydrophobic applications. While various fabrication approaches for reentrant micropillars are developed, including etching and 3D print techniques, these methods remain constrained by critical challenges: low‐throughput manufacturing, compromised structural …

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MicroRNA-93-5p alleviates uric acid-induced fibrosis in renal tubular epithelial cells by regulating the SMAD5/Id2 signaling pathway

Xun Lu, Chengxin Ma, Dongxiao Li, Jianan Yang et autres

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Oxidative stress-related biomarkers in thyroid eye disease: evidence from bioinformatics analysis and experimental validation

Yuanping Hai, Qintao Ma, Zhitao Liu, Dongxiao Li et autres

Background Oxidative stress is a key contributor to the pathogenesis of the autoimmune condition thyroid eye disease (TED). However, its precise molecular mechanisms and reliable biomarkers remain unclear. Bioinformatics enables the identification of differentially expressed genes through transcriptomic analysis. However, distinguishing truly …

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Inhibition of Sirtuin 2 enhances autophagy and restores neuronal function in aged hippocampal neurons

Zhenyuan Zhang, Lan Zhang, Yidan Zhang, Ya Gao et autres

Age-related cognitive decline is linked to impaired autophagy and hippocampal dysfunction. This study investigates the role of Sirtuin 2 (SIRT2) in age-related cognitive decline, focusing on its impact on autophagy and hippocampal function. Quantitative proteomic analysis revealed 67 significantly dysregulated proteins in …

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Association Between Hemoglobin, Albumin, Lymphocyte, and Platelet Score and Diabetic Foot Ulcer: A Cross-Sectional Study

Zhaojie Li, Hui Guo, Zhihong Fu, Dongxiao Li et autres

BackgroundDiabetic foot ulcer (DFU) is a common and serious complication of diabetes mellitus, with high rates of disability and mortality. Early diagnosis and prevention can effectively reduce its incidence. The relationship between hemoglobin, albumin, lymphocyte count, and platelet (HALP) score, which are …

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VEGF ameliorates acute kidney injury by suppressing ferroptosis through activation of the ERK1/2-NRF2 pathway

Xiangtian Liu, Yuqi Song, Liping Ye, Dongxiao Li et autres

Vascular endothelial growth factor (VEGF) plays a crucial role in maintaining renal homeostasis. However, the precise impact of VEGF on ferroptosis in acute kidney injury (AKI) remains incompletely understood. This study aims to investigate the effects of VEGF on ferroptosis in the …

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519: GPNMB+ MACROPHAGES FACILITATE CD8+ T CELL EXHAUSTION BY IL-10 IN VESSEL CO-OPTION OF HEPATOCELLULAR CARCINOMA

Dongxiao Li, Dan Yang, Meng Xie, Shumin Dang et autres