Ying He

The impact of housing cost burden on self-rated health among urban renters in China

Dongsheng Zhan, Ying He, Wang De, Zichen Wang

Since China's market-oriented housing reform, rapidly rising urban housing prices and declining affordability have made housing cost burden a critical factor affecting the health and well-being of urban residents, particularly vulnerable groups such as renters. While previous literature has examined the relationship …

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The glioblastoma ecosystem: clonal evolution, heterogeneity, and therapeutic resistance

Ying He, Wenxue Song, Shuo Li, Jing Guo

Therapeutic resistance and recurrence represent major clinical challenges in glioblastoma (GBM), driven by profound tumor heterogeneity and continuous clonal evolution under therapeutic pressure. Conventional diagnostic and therapeutic strategies, which rely on static sampling, struggle to effectively address this dynamic ecosystem. This review …

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Near-infrared activatable engineered bacteria for synergistic cancer photo-immunotherapy

Qinglian Hu, Ying He, Zhuoting Lu, Jie Liu et autres

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Ketogenic diet inhibits glioma progression by promoting gut microbiota-derived butyrate production

Mingliang Chen, Ying He, Xunhu Dong, Hao-Fei Liu et autres

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Distinct effects of semaglutide and tirzepatide on metabolic and inflammatory gene expression in brown adipose tissue of mice fed a high-fat, high-fructose diet

Tianyi Ma, Fanfan Song, Yingying Pan, Ying He et autres

Background Brown adipose tissue (BAT) is crucial for overall energy homeostasis as a thermogenic organ with high metabolic activity. While the recruitment of BAT contributes to improved glycemic and lipid homeostasis, the exact molecular mechanisms remain incompletely understood. Objective This investigation compared …

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2135P FS-1502 in patients with HER2 expression, locally advanced or metastatic gastric or gastroesophageal junction adenocarcinoma (GC/GEJ): An open-label, multicenter, phase II study

Yihu Zheng, Jie Wang, Zhongxin Li, Jianfeng Yang et autres

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Efficacy and safety of Shouhui Tongbian Capsules, a traditional Chinese medicine, combined with 2L polyethylene glycol for bowel preparation before colonoscopy: a multicenter, randomized, single-blind, parallel-controlled clinical trial

Feng Ye, Ni Guo, Yaping Wang, Baochun Wang et autres

Background: High-volume polyethylene glycol (PEG) solutions are commonly used for bowel preparation but are often poorly tolerated, reducing patient compliance. Shouhui Tongbian Capsules (SHTBC), a traditional Chinese medicine known to promote gastrointestinal motility, may offer an alternative approach. However, its role in …

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ACAT2 contributes to cervical cancer tumorigenesis by regulating the expression of the downstream gene LATS1

Hui Wang, Zhe Wang, Huancheng Su, Lili Wang et autres

Abstract Objectives Cervical cancer poses a significant health threat. While acetyl-CoA acetyltransferase 2 (ACAT2) gene is known to promote hepatocellular carcinoma progression, its role in cervical cancer remains unclear. This study aims to elucidate the function of ACAT2 in cervical cancer. Methods …

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Moderate exercise relieves heart failure-induced skeletal muscle atrophy through the inhibition of MAPK/SOCS3 signaling

Ying Zhao, Ying Zhang, Rui Song, Ying He

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Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Wenjing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang et autres

Hepatocellular carcinoma (HCC), the sixth most prevalent cancer globally, is characterized by high recurrence rates and poor prognosis. Investigating the heterogeneity of relapsed HCC and identifying key therapeutic targets may facilitate the design of effective anticancer therapies. In this study, integrative analysis …

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Alveolar metabolite availability facilitates secondary infection by Pseudomonas aeruginosa in acutely injured lungs

Jennifer M. Baker, Thomas L. Flott, L. McLellan, Ingrid Gisell Bustos et autres

Abstract Secondary bacterial pneumonia is a frequent complication of acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS). Prior efforts to explain increased pneumonia risk in ALI/ARDS have focused on impaired immunity and bacterial virulence, but have overlooked the potential …

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A kinetochore-associated kinesin-7 motor cooperates with BUB3.3 to regulate mitotic chromosome congression in Arabidopsis thaliana

Xiaoya Tang, Ying He, Yihang Tang, Keqi Chen et autres

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