Xunhu Dong

Induction of transferrin receptor 1-mediated ferroptosis by ultrasound-triggered microbubble destruction sensitizes glioblastoma to radiotherapy

Ying He, Xunhu Dong, Xiaolu Lu, Qiong Zhu et autres

Abstract Ultrasound-triggered microbubble destruction (UTMD), a non-invasive technique, has been proposed as a promising means of improving the efficacy of radiotherapy against glioblastoma (GBM); however, the underlying mechanisms remain to be fully clarified. Here, UTMD was shown to induce ferroptosis, an iron-dependent …

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Prostate specific membrane antigen-targeted multimodal imaging nanobubbles with ultrasound irradiation inhibit prostate cancer growth via autophagy activation

Yi Ling, Xunhu Dong, Jun Zhang, Deng Liu et autres

Ultrasound-targeted nanobubble destruction (UTND) is a promising noninvasive strategy for cancer treatment. However, off-target effects significantly influence UTND-mediated therapeutic efficacy and compromise accurate evaluation of tumors. Prostate-specific membrane antigen (PSMA) is overexpressed on the membranes of prostate cancer (PCa) cells, making it …

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Ketogenic diet inhibits glioma progression by promoting gut microbiota-derived butyrate production

Mingliang Chen, Ying He, Xunhu Dong, Hao-Fei Liu et autres

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Targeting LINC00707 by vitamin D3 attenuates nitrogen mustard-caused dermal toxicity through inhibiting ferroptosis

Xunhu Dong, Ying He, Xiaofeng Hu, Jie Wu et autres

and malondialdehyde contents in vitro and in vivo. Ferrostin-1 (Fer-1, a ferroptosis inhibitor) attenuated NM-caused cell death in keratinocytes. Meanwhile, NM significantly inhibited phosphorylation of AKT1 and glycogen synthase kinase 3β (GSK3β) and nuclear factor erythroid 2-related factor 2 (Nrf2) nuclear translocation, …

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PSMA-TARGETED NANOBUBBLES FOR ENHANCED MULTIMODAL MOLECULAR IMAGING AND TARGETED TREATMENT OF PROSTATE CANCER

Yi Ling, Xunhu Dong, Jun Zhang, Deng Liu et autres

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Asiatic acid improves the damage of HaCaT cells induced by nitrogen mustard through inhibiting endoplasmic reticulum stress

Haoyin Liu, Jin Shiung Cheng, Feng Ye, Xunhu Dong et autres

Nitrogen mustard (NM) belongs to vesicant agents. Blisters are one of the important characteristics of NM skin damage. It is urgent to further elucidate the mechanism and develop effective countermeasures for the skin damage induced by NM. The endoplasmic reticulum (ER) is …

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Nitrogen mustard induces dynamic nuclear protein spectrum change and DNA-protein crosslinking, with p97 mediating repair

Jin Shiung Cheng, Haoyin Liu, Wenpei Yu, Xunhu Dong et autres

Nitrogen mustard (NM) is a chemotherapeutic agent capable of alkylating nucleophilic proteins and DNA, causing severe cell damage. However, no reports have been on the dynamic changes in proteomics induced by NM. In this study, we established a model of acute exposure …

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RNA-binding proteins signature is a favorable biomarker of prognosis, immunotherapy and chemotherapy response for cervical cancer

Xiaomei Chen, Xunhu Dong, Hong Li, Tingting Wu et autres

Cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) still present a huge threaten to women's health, especially the local advanced patients. Hence, developing more effectiveness prognostic signatures is urgently needed. This study constructed and verified a robust RNA-binding proteins (RBPs) related signature …

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The association of sun-cured tobacco and cigarette use with global cognitive function, verbal fluency and memory in patients with chronic obstructive pulmonary disease: A cross-sectional study

Xiaomei Chen, Jie Li, Jia Liu, Xiao Liu et autres

INTRODUCTION: Some elderly people in China prefer sun-cured tobacco to cigarettes, and the composition of sun-cured tobacco and cigarettes is inconsistent. The influence of cigarettes on the cognitive function of COPD patients has been widely reported, but the research on sun-cured tobacco …

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Rural–Urban Differences in Mild Cognitive Impairment Among Patients with Chronic Obstructive Pulmonary Disease in ChengDu, China

Xiaomei Chen, Xunhu Dong, Jia Liu, Xiao Liu et autres

Purpose: The rural-urban gap in sociodemographic, lifestyle, and disease-related characteristics among COPD patients is prevalent. These differences may influence the prevalence of mild cognitive impairment (MCI). This study aimed to compare the prevalence and determinants of MCI between rural and urban areas …

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HSP90/CDC37 inactivation promotes degradation of LKB1 protein to suppress AMPK signaling in bronchial epithelial cells exposed to sulfur mustard analog, 2-chloroethyl ethyl sulfide

Feng Ye, Xiaogang Wang, Xunhu Dong, Jin Shiung Cheng et autres

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Vitamin D3 attenuates SARS‐CoV‐2 nucleocapsid protein‐caused hyperinflammation by inactivating the NLRP3 inflammasome through the VDR‐BRCC3 signaling pathway in vitro and in vivo

Mingliang Chen, Ying He, Xiaofeng Hu, Xunhu Dong et autres

Abstract Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection‐caused coronavirus disease 2019 (COVID‐19) is a global crisis with no satisfactory therapies. Vitamin D3 (VD3) is considered a potential candidate for COVID‐19 treatment; however, little information is available regarding the exact effects of …

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