Shukang Zhao

Association between PLVAP downregulation and increased lymphocyte infiltration in newly diagnosed glioblastoma treated with bevacizumab

Hiroaki Matsuzaki, Shukang Zhao, Yoshihiro Komohara, Cheng Pan et autres

Glioblastoma (GBM) is a highly lethal brain tumor resistant to immunotherapy such as immune checkpoint inhibitors, partly because of an immunosuppressive tumor microenvironment and blood-brain barrier (BBB) dysfunction. Although bevacizumab can remodel the tumor vasculature, the relationship between BBB-related vascular changes and …

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Clear Cell Renal Cell Carcinoma With Syncytial Giant Cells: A Case Report With Morphological and Immune-microenvironmental Characterization

YOJIRO OZAKI, JUNNOSUKE IMAFUJI, Ayano Uekawa, Yuki Ibe et autres

Background/Aim: Clear cell renal cell carcinoma (ccRCC) is the most frequent kidney cancer, and its clinical course has been improved by the development of new anticancer immunotherapies. A rare variant of ccRCC is characterized by the presence of syncytial giant cells (SGCs), …

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A lung squamous cell carcinoma demonstrating spontaneous partial regression of the primary tumor with lymph node metastasis: a case report with analysis of the tumor immune microenvironment

Hiroyuki Yamada, Yoshihiro Komohara, T. Koga, Shukang Zhao et autres

Background: Spontaneous regression (SR) of malignant tumors is a well-known but rare phenomenon in lung cancer. Previous studies have suggested that antitumor immune responses may contribute to SR. Case Description: We report the case of a 74-year-old man with a right lower …

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Hofbauer cell alterations and potential role in the pathophysiology of HELLP syndrome

Ayano Ezaki, Akihito Sagara, Yoshihiro Komohara, Cheng Wei Pan et autres

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The expression of PD-1 ligands in the immune microenvironment was altered in TTF-1-negative lung adenocarcinoma

Hiroyuki Yamada, Hiromu Yano, Eri Matsubara, Shukang Zhao et autres

Abstract Thyroid transcription factor-1 (TTF-1) is a lineage-specific marker for lung adenocarcinoma (LUAD), whereas the relatively minor subset of TTF-1-negative LUADs shows a poor prognosis and a limited response to therapy. However, its relationship with the tumor immune microenvironment remains poorly defined. …

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Anaplastic thyroid carcinoma with osteoclast-like giant cells: a case report and a study of a potential therapeutic approach

Kaori Yukino, Yoshihiro Komohara, Shukang Zhao, Rin Yamada et autres

Anaplastic thyroid carcinoma (ATC) is a highly aggressive neoplasm with no effective treatment options. ATC with osteoclast-like giant cells (OGCs; ATC/OGC) is a rare variant of ATC, and no detailed pathological examination has been reported to date. A 59-year-old woman presented with …

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The expression of PD-1 ligands in the immune microenvironment was altered in TTF-1-negative lung adenocarcinoma

Hiromu Yano, Eri Matsubara, Shukang Zhao, Yusuke Shinchi et autres

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IL-32 production from lung adenocarcinoma cells is potentially involved in immunosuppressive microenvironment

Shukang Zhao, Lianbo Li, Yoshihiro Komohara, Eri Matsubara et autres

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The Significance of SPP1 in Lung Cancers and Its Impact as a Marker for Protumor Tumor-Associated Macrophages

Eri Matsubara, Hiromu Yano, Cheng Wei Pan, Yoshihiro Komohara et autres

Macrophages are a representative cell type in the tumor microenvironment. Macrophages that infiltrate the cancer microenvironment are referred to as tumor-associated macrophages (TAMs). TAMs exhibit protumor functions related to invasion, metastasis, and immunosuppression, and an increased density of TAMs is associated with …

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Grounding Operation Analysis of Low Voltage Direct Current Supply and Utilization System

Shukang Zhao, Yuanyuan Sun, Kaiqi Sun, Shulin Yin et autres

With the large-scale integration of the distributed photovoltaic (PV) power generation system and power-electronic-device-based loads such as electric vehicles and data centers. The low voltage direct current supply and utilization system (LVDCSUS) has received much attention from academics and industry in recent …

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Flicker Source Location and Responsibility Division Method Considering Flicker Power Fluctuation Characteristics

Ruize Sun, Yuanyuan Sun, Shulin Yin, Shukang Zhao et autres

Aiming at the voltage fluctuation and flicker problem caused by renewable energy mass access, a flicker detection and flicker responsibility division method based on the flicker power are proposed in this paper. This method first uses probabilistic neural networks (PNN) and Hilbert-Huang …

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[Corrigendum] Isolation of circulating tumor cells in patients undergoing surgery for esophageal cancer and a specific confirmation method

Yunpeng Zhao, Shukang Zhao, Ying‐Jie Chen, Xiaopeng Dong et autres

Subsequently to the publication of this article, the Editor of Oncology Letters received notification that the use of the abbreviation “ISET” in this paper represented an infringement of a trademark owned by the company “Rarecells”, who are the exclusive licensee of several …

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