Sung Ho Lee

Whole-Exome Sequencing Improves Risk Assessments of Adult Moyamoya Disease

Eun Pyo Hong, Eun Jin Ha, Dong Hyuk Youn, Yuwhan Chung et autres

Background and Purpose Whole-exome sequencing (WES) is a valuable tool for identifying causative mutations in adult moyamoya disease (MMD), thereby advancing our understanding of the genetic mechanisms underlying this condition.Here, we conducted the first WESbased association study aimed at identifying genetic modifiers …

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Risk of peripartum cerebrovascular events in women with moyamoya disease: A multicenter cohort study

Hyunjun Cho, Tae Keun Jee, Sang Hyo Lee, Jae Seung Bang et autres

Background: Pregnancy and delivery are known to increase the risk of cerebrovascular events (CVEs) in patients with moyamoya disease (MMD). This study determined the frequency, risk factors, and outcome of CVEs during pregnancy in MMD. Methods: We conducted a multicenter study involving …

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Indirect revascularization after bypass surgery for intracranial atherosclerotic steno-occlusive disease

Yuwhan Chung, Sung Ho Lee, Kang-Min Kim, Hyun‐Seung Kang et autres

OBJECTIVES: Indirect revascularization after bypass surgery for intracranial atherosclerotic steno-occlusive disease (ICAD) remains controversial. We aimed to evaluate indirect revascularization after direct bypass surgery in patients with ICAD. METHODS: Among 245 patients with ICAD who underwent direct bypass surgery between 2003 and …

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Preliminary results of pravastatin on non-hemorrhagic vertebral artery dissection: an exploratory randomized and controlled study

Hyun Jin Han, Keun Young Park, Chang Ki Jang, Joonho Chung et autres

BACKGROUND: There is limited information about the pleiotropic effects of statin on cerebrovascular diseases. The authors aimed to investigate the effect of pravastatin on non-hemorrhagic vertebral artery dissection (VAD) in a clinical setting. METHODS: An exploratory randomized and controlled study was designed …

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Expeditious synthesis of carbon nanotubes by localized and high-frequency induction heating system for enhanced field emission characteristics

Jinho Choi, Amar Prasad Gupta, Jiwon Yoon, Jaeik Jung et autres

This study demonstrates rapid carbon nanotube (CNT) synthesis using a 150 kHz induction heating system, enabling precise temperature and pressure control in thermal chemical vapor deposition processes. CNT growth optimization at temperatures between 887 and 955 °C and pressures from 1 to …

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Usefulness of Three-Dimensional-Printed Models in Clipping Intracranial Aneurysms via Keyhole Approaches: A Randomized Controlled Study

Sung Ho Lee, Young Hoon Choi, Young Sill Kang, Hyunseok Oh et autres

Three-dimensional (3D)-printed modeling in the treatment of cerebrovascular diseases is rapidly developing. The present study aimed to evaluate the clinical and educational efficacy of 3D-printed models in surgical clipping of intracranial aneurysms. A single-center, randomized, controlled study was conducted for patients with …

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Comparison of Clazosentan and Nimodipine on Vasospasm and Vasospasm-Related Outcomes after Aneurysmal Subarachnoid Hemorrhage : A Post-hoc Propensity Score-Matched Analysis of Six Randomized Clinical Trials

Sung Ho Lee, Kyu-Sun Choi, Osamu Togo, Ik Seong Park

OBJECTIVE: Clazosentan is a recently approved endothelin receptor antagonist indicated for the prevention of vasospasm and related complications following aneurysmal subarachnoid hemorrhage (aSAH). To date, no direct, head-to-head comparison between clazosentan and nimodipine has been conducted. In this study, we indirectly assessed …

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Intra-individual comparison of long-term outcomes between combined and indirect bypass surgery in adult moyamoya disease

Yuwhan Chung, Jeong Eun Kim, Hyun‐Seung Kang, Tae Young Kim et autres

Abstract Purpose Bypass surgery is regarded as the standard treatment option for symptomatic and hemodynamically unstable moyamoya disease (MMD). However, there is ongoing debate about the most effective type of bypass surgery. We aimed to analyze the long-term outcomes of combined and …

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A common data model for oral anticoagulants-related risk of spontaneous intracranial hemorrhage

Noah Hong, Yeh-Hee Ko, Jeong Hyun Park, Eun Jin Ha et autres

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Trends in Incidences, Treatments and Outcomes of Spontaneous Subarachnoid Hemorrhage in Korea Between 2002 and 2022

Jinju Park, Ji Yoon Baek, Sung Ho Lee, Keun‐Hwa Jung et autres

BACKGROUND: Access to equitable care for severely emergent diseases serves as a key indicator for evaluating the performance of a country's health care system. The aim of this study was to examine trends in the incidence, treatment and outcomes of patients with …

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Autoregulatory dysfunction in adult Moyamoya disease with cerebral hyperperfusion syndrome after bypass surgery

Jin Hyung Kim, Noah Hong, Hakseung Kim, Young Hoon Choi et autres

Cerebral hyperperfusion syndrome (CHS) is a serious complication after bypass surgery in Moyamoya disease (MMD), with autoregulatory dysfunction being a major pathogenesis. This study investigated the change of perioperative autoregulation and preoperative prognostic potentials in MMD with postoperative CHS. Among 26 hemispheres …

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Two-Stage Whole-Exome Sequencing Improves to Predict a Risk of Adult Moyamoya Disease in 369,570 Individuals

Eun Pyo Hong, Eun Jin Ha, Dong Hyuk Youn, Yuwhan Chung et autres

kr (code pays fourni par la source)