Huanyu Wang

Impact of an antimicrobial stewardship-based infection prevention bundle on postoperative central nervous system infection in a tertiary neurosurgery department: a quasi-experimental study

Yuan Zhang, Binge Chang, Huanyu Wang, Yi Zhang et autres

Background Antimicrobial stewardship integration into infection prevention bundles remains inadequately addressed in neurosurgery. Aim To evaluate the impact of an antimicrobial stewardship-based infection prevention bundle on postoperative central nervous system infection (PCNSI) incidence, antibiotic use density (AUD), and consumption of vancomycin and …

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Participant perceptions of the impact of the ModPad program on molecular diagnostic capacity building and public health practices

Ning Feng, Ma Xuejun, Li Jiandong, Huanyu Wang et autres

Objective To investigate the perceptions of the participants having attended the International Training Program on Molecular Diagnosis and Pathogen Determination (ModPad) about its enhancing effect on their molecular diagnostic capacity as well as related public health practices. Method A cross-sectional survey was …

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Ursolic acid mitigates hepatic ischemia-reperfusion injury by regulating the ALOX12/12(S)-HETE and PTGES/prostaglandin E2 axis via arachidonic acid metabolism pathway

Wen Hou, Jiansen Lu, Hao Pan, Huanyu Wang et autres

Introduction: Hepatic ischemia-reperfusion injury (HIRI) is a critical contributor to poor prognosis after hepatobiliary surgery, yet effective therapeutic strategies remain limited. Ursolic acid (UA), a natural pentacyclic triterpenoid, has shown potential hepatoprotective properties, but its specific mechanism in alleviating HIRI remains unclear. …

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Nanoparticle Vaccines Based on the Truncated VZV gE Elicit a Robust Immune Response in Mice

Tianxin Shi, Li Hai, Jiehui Wu, Hongqiao Hu et autres

Background: Herpes zoster (HZ), caused by the reactivation of varicella-zoster virus (VZV), primarily affects elderly populations worldwide. Although current recombinant HZ vaccines show strong immunogenicity, their high cost and potential side effects may limit their widespread use. Therefore, developing a cost-effective HZ …

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Genomic and Transcriptomic Characterization of Umatilla Virus Isolated and Identified from Mosquitoes in Ningxia, China

Yuhong Yang, Long Wang, Liqin Yu, Ruichen Wang et autres

During the 2023 surveillance of mosquito-borne viruses in Ningxia Hui Autonomous Region, a strain of Umatilla virus (UMAV) was isolated from a pool of Culex pipiens pallens (NX23166) collected in Xiji County and cultured in C6/36 cells. Electron microscopy revealed that NX23166-infected …

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The NREP-GPX4 Axis Regulates Epithelial-Mesenchymal Transition and Enhances EGFR-TKI Resistance in Lung Adenocarcinoma Cells

Wenxiang Wei, Qiuli Li, Wei Yang, Wenjing Dai et autres

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Author response for "Strong Ligand-Modified Polyaniline Decorated with Cobalt Nanoparticles Optimizes Surface Electron Density for Efficient Oxygen Evolution"

Jiangbo Chen, Shanjun Chen, Huanyu Wang, Yong Zheng et autres

Incidence and risk factors for recurrent venous thromboembolism, recurrent stroke and bleeding in Chinese patients with acute ischemic stroke and cancer : a real-world study

Yuan Zhang, Huanyu Wang, Hu Ren, Yi Lu et autres

BACKGROUND: Patients with acute ischemic stroke (AIS) and cancer are at exceptionally high risk for recurrent thromboembolism (RTE), which includes venous thromboembolism (VTE) and arterial thromboembolism (ATE). Yet contemporary data from Chinese patients remain scarce. METHODS: In this retrospective, observational study conducted …

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Immunogenicity, immune persistence, and safety of japanese encephalitis vaccine schedules among adults in Ningxia, China

Dan Wu, Qikai Yin, Ying Zhang, Yixing Li et autres

Live attenuated and vero-cell-inactivated Japanese Encephalitis vaccines (LJEV, IJEV) have been in common use in young children in China since 1989 and 2004, associated with large reductions in Japanese encephalitis (JE) incidence. In 2013, northern China reported JE outbreaks among adults born …

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Peripheral nerve injury mediated by JEV strain NX1889 infection and impairment of Schwann cells

Liping Yang, Yanping Yuan, Qikai Yin, Xiaocong Li et autres

Japanese encephalitis virus (JEV) is a mosquito-borne flavivirus primarily associated with central nervous system disorders. Recent studies have indicated that JEV infection can lead to Guillain-Barré syndrome (GBS), a peripheral nervous system (PNS) disorder; however, the underlying mechanisms remain unclear. In this …

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Neonatal mouse model reveals pathogenesis of Shanxi Tick Virus 2 isolated from Haemaphysalis longicornis

Fan Li, R L Wang, B. Zhang, Guangjun Jin et autres

Shanxi Tick Virus 2(SXTV2), a Tamdy group member of Orthonairovirus genus, Nairoviridae family, was initially identified through Next Generation Sequencing, with its pathogenicity and risk profile remaining unclear. This study reports the first successful isolation of SXTV2 from Haemaphysalis longicornis ticks collected …

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Numbers to Be Clarified in the Danish Benzodiazepine Receptor Agonists Cohort Study

Jia‐Chi Shan, Huanyu Wang, Ching-Jui Chang

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