Li Hai

Unveiling the anti-inflammatory power of star anise-cinnamon compound essential oil against MDR Salmonella

Ziheng Xu, J Zhang, Rongdian Lin, Zuxiang Luan et autres

Introduction: This study aimed to investigate the antiinfi ammatory effects and potential molecular mechanisms of star anise-cinnamon compound essential oil (SCEO) against multidrug-resistant Salmonella Thompson (MDR S. Thompson) infection in mice. Methods: An intestinal infection model was established in mice by oral …

cn (code pays fourni par la source)

Association of Helicobacter pylori infection with the correa cascade: a single-center, retrospective cohort study

Zhangsen Huang, Liang Gu, Y J Shi, Songyao Chen et autres

Background Helicobacter pylori ( H. pylori ) is a primary etiological agent for various gastric pathologies. Although numerous studies have described the association between H. pylori and individual stages of the Correa cascade, data comprehensively evaluating its prevalence across the full histopathological …

cn, gb (code pays fourni par la source)

Identification of salivary lipid biomarkers for noninvasive diagnosis of reflux esophagitis via UHPLC-MS-based lipidomics

Yue Wang, Ying Zhou, Jian Gao, Lin Zhang et autres

INTRODUCTION: Reflux esophagitis (RE) is a common upper gastrointestinal disorder, and its diagnosis currently relies primarily on invasive endoscopic examination. The lack of reliable non-invasive biomarkers substantially limits early detection and large-scale screening. Saliva represents a promising biofluid for metabolomics research, as …

cn (code pays fourni par la source)

Association analysis of the differences in intestinal flora and clinical tumor indicators among colorectal cancer patients

Lan Ma, Wenjing Wang, shihu Ma, Yanbai Wang et autres

Background Colorectal cancer (CRC) is the third most common malignant tumor globally, and its development is closely related to intestinal flora dysbiosis. However, the heterogeneity of cancerous tissues, paracancerous tissues, and fecal flora, and their clinical significance, has not been fully elucidated. …

cn (code pays fourni par la source)

Nanoparticle Vaccines Based on the Truncated VZV gE Elicit a Robust Immune Response in Mice

Tianxin Shi, Li Hai, Jiehui Wu, Hongqiao Hu et autres

Background: Herpes zoster (HZ), caused by the reactivation of varicella-zoster virus (VZV), primarily affects elderly populations worldwide. Although current recombinant HZ vaccines show strong immunogenicity, their high cost and potential side effects may limit their widespread use. Therefore, developing a cost-effective HZ …

cn (code pays fourni par la source)

Nanobody-based combination vaccine using licensed protein nanoparticles protects animals against respiratory and viral infections

Tingting Li, Wenhui Xue, Sibo Zhang, Hong Wang et autres

cn, hk (code pays fourni par la source)

Evaluating Free PPV23 Vaccination for the Elderly in Nanning, China: A Cost-Effectiveness Analysis

Z. Su, Linlin Deng, Dan Luo, Jianying Ren et autres

Background: This study aims to evaluate the cost-effectiveness of providing the 23-valent pneumococcal polysaccharide vaccine (PPV23) free of charge versus self-paying vaccination among adults aged 60 years and older in Nanning, Guangxi, China. Methods: A decision tree–Markov model was developed to compare …

cn (code pays fourni par la source)

Research Progress on Varicella-Zoster Virus Vaccines

Hongjing Liu, Lingyan Cui, Sibo Zhang, Hong Wang et autres

Varicella-zoster virus (VZV) poses significant public health challenges as the etiological agent of varicella (chickenpox) and herpes zoster (HZ), given its high transmissibility and potential for severe complications. The introduction of VZV vaccines-particularly the vOka-based live attenuated and glycoprotein gE-based recombinant subunit …

cn (code pays fourni par la source)

Development and validation of a radiomics-based prediction model for variceal bleeding in patients with Budd-Chiari syndrome-related gastroesophageal varices

Zedong Wang, Huijie Nan, Su-Xin Li, Lu-Hao Li et autres

BACKGROUND Budd-Chiari syndrome (BCS) is caused by obstruction of the hepatic veins or suprahepatic inferior vena cava, leading to portal hypertension and the development of gastroesophageal varices (GEVs), which are associated with an increased risk of bleeding. Existing risk models for variceal …

cn (code pays fourni par la source)

CTSO and HLA-DQA1 as biomarkers in sepsis-associated ARDS: insights from RNA sequencing and immune infiltration analysis

Yi Shen, Yi Yao, Li Hai, Yang Li et autres

The onset of sepsis frequently coincides with acute respiratory distress syndrome (ARDS), which constitutes a significant contributor to severe acid-base disturbances in septic patients. In the pathogenesis of sepsis, it conducts a crucial role. lysosomal metabolic disorders and immune imbalance conduct a …

cn (code pays fourni par la source)

S100P is a core gene for diagnosing and predicting the prognosis of sepsis

Yi Shen, Li Hai, Ying Hu

Sepsis, characterized as a severe systemic inflammatory response syndrome, typically originates from an exaggerated immune response to infection that gives rise to organ dysfunction. Serving as one of the predominant causes of death among critically ill patients, it’s pressing to acquire an …

cn (code pays fourni par la source)

Chinese Guideline for the Diagnosis and Management of Drug‐Induced Liver Injury in Primary Care (2024)

Yimin Mao, Jie Tang, Zhonghua Lu, Ming Shao et autres

Drug-induced liver injury (DILI) is a drug-induced disease that not only complicates the treatment of the primary disease but may also lead to acute liver failure or even death in severe cases. Drugs commonly used in primary care, such as anti-infective agents …

cn (code pays fourni par la source)