Hongtao Cheng

The YTHDC1/HECW1/SMAD7 axis drives cisplatin resistance in bladder cancer

Weigang Ren, Jiaxiang Yi, Mingqiang Zeng, Hongtao Cheng

Background: Cisplatin-based combination chemotherapy remains the cornerstone of treatment for advanced bladder cancer (BC). However, primary or acquired resistance following long-term use remains a critical unresolved issue in BC treatment. While accumulating evidence implicates epitranscriptomic modifications in driving chemoresistance, the precise underlying …

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Glabridin from Glycyrrhiza glabra L. Exhibits Anti-Triple-Negative Breast Cancer Effects by Regulating Various Cell Cycle Genes

Chong Yuan, Lingli Zhang, Qi Tao, Hongmei Zheng et autres

Glabridin (GLA), a characteristic polyphenolic extracted from the renowned sweet plant Glycyrrhiza glabra L., demonstrates potent anticancer effects. This study aims to investigate the effects of GLA on triple-negative breast cancer (TNBC) and its underlying mechanisms. The IC 50 values of GLA …

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CRISPR/Cas9-mediated editing of uORFs in the BnVTC2 facilitates abiotic stress resilience without yield penalty

Mengyu Hao, Yilin Li, Shifei Sang, Yunfei Wen et autres

Upstream open reading frame (uORF)-based genetic engineering has emerged as an excellent strategy for improving agronomic traits of crops. Despite its significant potential, the exploration of CRISPR/Cas-based uORF engineering in many crop species remains unexplored, thereby limiting the application of this approach …

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Comprehensive evaluation of alkaline tolerance in Brassica napus at the seedling stage

Zhikang Hu, Yu SHU, Hui WANG, Ying-Ying YANG et autres

Genome-Wide Association Study Reveals Candidate Genes Regulating Plant Height and First-Branch Height in Brassica napus

Tianyu Cui, Xinao Wang, Wenxiang Wang, Hongtao Cheng et autres

Rapeseed (Brassica napus L., 2n = 38) is an important oil crop worldwide, providing vegetable oil and biofuel. Despite improvements in breeding, rapeseed’s harvest index and yield remain lower than other major crops. Plant height (PH) and first-branch height (FBH) are crucial …

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Optimization and application of genome prediction model in rapeseed: flowering time, yield components, and oil content as examples

Wen-Kai Yu, Xinao Wang, Hui Wang, Wenxiang Wang et autres

Rapeseed is the second largest oilseed crop in the world with short domestication and breeding history. This study developed a batch of genomic prediction models for flowering time (FT), oil content, and yield components in rapeseed. Using worldwide 404 breeding lines, the …

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Integrative analyses reveal Bna‐miR397a–BnaLAC2 as a potential modulator of low‐temperature adaptability in Brassica napus L.

Muhammad Azhar Hussain, Yong Huang, Dan Luo, Sundas Saher Mehmood et autres

Brassica napus L. (B. napus) is a major edible oil crop grown around the southern part of China, which often faces cold stress, posing potential damage to vegetative tissues. To sustain growth and reproduction, a detailed understanding of fundamental regulatory processes in …

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Predicting High‐Flow Nasal Cannula Oxygen Therapy Failure in Patients With Acute Hypoxaemic Respiratory Failure Using Machine Learning: Model Development and External Validation

Hongtao Cheng, Zichen Wang, Mei Feng, Yonglan Tang et autres

AIMS AND OBJECTIVES: To develop and validate a prediction model for high-flow nasal cannula (HFNC) failure in patients with acute hypoxaemic respiratory failure (AHRF). BACKGROUND: AHRF accounts for a major proportion of intensive care unit (ICU) admissions and is associated with high …

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Elderly patients with dysphagia in the intensive care unit: Association between malnutrition and delirium

Xin Liang, Xinya Li, Hongtao Cheng, Fangxin Wei et autres

BACKGROUND: Dysphagia, as a geriatric syndrome, is prevalent in the intensive care unit (ICU). Malnutrition resulting from swallowing disorders is likely to correlate with adverse ICU outcomes, including delirium, thereby escalating the costs of care and hospitalization. However, malnutrition has not received …

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Safety and efficacy of tract embolization using gelatin sponge particles in reducing pneumothorax after CT-guided percutaneous lung biopsy in patients with emphysema

Yang Xiong, Hongtao Cheng, Yue Huang, Yuan Guo et autres

BACKGROUND: The incidence of pneumothorax is higher in patients with emphysema who undergo percutaneous lung biopsy. Needle embolization has been shown to reduce the incidence of pneumothorax in patients with emphysema. Existing studies have reported small sample sizes of patients with emphysema, …

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Association between modified frailty index and postoperative delirium in patients after cardiac surgery: A cohort study of 2080 older adults

Hongtao Cheng, Yitong Ling, Qiugui Li, Xinya Li et autres

AIM: To evaluate the association between frailty and postoperative delirium (POD) in elderly cardiac surgery patients. METHODS: A retrospective study was conducted of older patients admitted to the intensive care unit after cardiac surgery at a tertiary academic medical center in Boston …

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Clinical significance of supraclavicular lymph node (SCLN) dissection for patients with breast cancer with ipsilateral SCLN metastasis.

Hongmei Zheng, Wenzhuang Shen, Chuang Chen, Jinxuan Hou et autres

e13110 Background: Breast cancer with ipsilateral supraclavicular lymph node (SCLN) metastasis is defined as Ⅲc stage according to the 8th AJCC system. It is still pending whether to exert SCLN dissection except for regional radiotherapy to such patients. Methods: Breast cancer patients …

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