Shilei Liu

Wu-Mei-Wan promotes ferroptosis in gallbladder cancer through STAT3 negative regulation: An integrated HPLC, proteomics, network pharmacology, and experimental validation study

Jingwei Zhao, Liuqing Shi, Yue Yang, Jiayun Zhu et autres

ETHNOPHARMACOLOGICAL RELEVANCE: As a traditional Chinese medicine, Wu-Mei-Wan (WMW) has shown promise as a second-line treatment for gallbladder cancer, but its mechanism remains to be explored. AIM OF THE STUDY: To determine the specific mechanism of WMW active ingredients (Palmatine et al.) …

cn (code pays fourni par la source)

Wu-Mei-Wan Promotes Ferroptosis in Gallbladder Cancer Through Stat3 Negative Regulation: An Integrated Hplc, Proteomics, Network Pharmacology, and Experimental Validation Study

Jingwei Zhao, Liuqing Shi, Yue Yang, Jiayun Zhu et autres

cn (code pays fourni par la source)

BRD9 promotes the progression of gallbladder cancer via CST1 upregulation and interaction with FOXP1 through the PI3K/AKT pathway and represents a therapeutic target

Cheng Zhao, Liu-Qing Shi, Si-Rui Sun, Hua-Kai Wang et autres

Gallbladder cancer (GBC) is highly aggressive and has poor prognosis, with most patients only diagnosed at an advanced stage. Furthermore, treatment options are limited, and their effect is unsatisfactory. Bromodomain-containing protein (BRD) is an epigenetic regulator that plays a carcinogenic role in …

cn (code pays fourni par la source)

Perioperative toripalimab plus neoadjuvant chemotherapy might improve outcomes in resectable esophageal cancer: an interim analysis of a phase III randomized clinical trial

Yan Zheng, Guanghui Liang, Dongfeng Yuan, Xianben Liu et autres

BACKGROUND: In the era of immunotherapy, neoadjuvant immunochemotherapy (NAIC) for the treatment of locally advanced esophageal squamous cell carcinoma (ESCC) is used clinically but lacks of high-level clinical evidence. This study aimed to compare the safety and long-term efficacy of NAIC followed …

cn, ca (code pays fourni par la source)

TRIM21-mediated ubiquitylation of TAT suppresses liver metastasis in gallbladder cancer

Zi-you Wu, Jian Zhang, Ziyao Jia, Ziyi Yang et autres

cn, jp, ca (code pays fourni par la source)

Research progress on the multi-omics and survival status of circulating tumor cells

Qingming Xie, Shilei Liu, Sai Zhang, Liqiu Liao et autres

In the dynamic process of metastasis, circulating tumor cells (CTCs) emanate from the primary solid tumor and subsequently acquire the capacity to disengage from the basement membrane, facilitating their infiltration into the vascular system via the interstitial tissue. Given the pivotal role …

cn (code pays fourni par la source)

NONO promotes gallbladder cancer cell proliferation by enhancing oncogenic RNA splicing of DLG1 through interaction with IGF2BP3/RBM14

Ziyi Yang, Cheng Zhao, Shilei Liu, Lijia Pan et autres

Gallbladder cancer (GBC) is a highly malignant and rapidly progressing tumor of the human biliary system, and there is an urgent need to develop new therapeutic targets and modalities. Non-POU domain-containing octamer-binding protein (NONO) is an RNA-binding protein involved in the regulation …

cn (code pays fourni par la source)

Identification of a lncRNA/circRNA-miRNA-mRNA network in Nasopharyngeal Carcinoma by deep sequencing and bioinformatics analysis

Shilei Liu, Xiaoxiao Li, Qingming Xie, Sai Zhang et autres

Background: Accumulating evidence indicates that non-coding RNAs (ncRNA), including long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), can function as competitive endogenous RNAs (ceRNAs) by binding to microRNAs (miRNAs) and regulating host gene expression at the transcriptional or post-transcriptional level.Dysregulation in ceRNA …

cn, us (code pays fourni par la source)

Prognostic Impact of Neoadjuvant Chemotherapy in Localized or Locoregionally Advanced Gallbladder Cancer: A Population-Based and Propensity Score Matched SEER Analysis

Yichen Xiong, Ziyi Yang, Albie Gong, Zi-you Wu et autres

Background The effect of neoadjuvant chemotherapy (NACT) in gallbladder cancer (GBC) patients remains controversial. The aim of this study was to assess the impact of NACT on overall survival (OS) and cancer specific survival (CSS) in patients with localized or locoregionally advanced …

cn, ca (code pays fourni par la source)

Identification and Validation of a Basement Membrane-Inflammatory Response-Related Gene Signature for Prognostic Assessment and Immunotherapy Responsiveness in Lung Adenocarcinoma Through the Integration of Bulk and Single-Cell Rna-Seq

Shilei Liu, Qingming Xie, Zhe Cheng, Jingru Shen et autres

cn (code pays fourni par la source)

Palladium/norbornene-catalyzed C–H/N–H cycloaddition of carbazoles with 2-halobenzoic acid derivatives

Shilei Liu, Jiang Nan, Nan An, Rui Cao et autres

An example of palladium/norbornene-catalyzed C-H/N-H cycloaddition of carbazoles with 2-bromobenzoic acids is presented, in which a collection of important carbazoles is expeditiously obtained. Derivatives, including acyl halides, α-oxocarboxylic acids, anhydrides, and even amides, are all allowed. Preliminary mechanistic studies reveal that a …

cn (code pays fourni par la source)

Prognostic Impact of Neoadjuvant Chemotherapy in Localized or Locoregionally Advanced Gallbladder Cancer: a Population-Based and Propensity Score Matched SEER Analysis

Yichen Xiong, Ziyi Yang, Albie Gong, Zi-you Wu et autres

Abstract Background: The effect of neoadjuvant chemotherapy (NACT) in gallbladder cancer (GBC) patients remains controversial. The aim of this study was to assess the impact of NACT on overall survival (OS) and cancer specific survival (CSS) in patients with localized or locoregionally …

cn, ca (code pays fourni par la source)