Limin Chen

Closed loop construction of hypoglycemia risk management for high risk neonates in mother infant rooming in settings: a retrospective study with an embedded clinical decision support system

Limin Chen, Hui Shao, Beimeng Yu, Min Wang et autres

Objective To evaluate the effectiveness of an intelligent clinical decision support system (CDSS) for neonatal hypoglycemia management in mother-infant rooming-in settings, and to dissect the differential hypoglycemia risk conferred by individual high-risk factors and their specific combinations under standardized surveillance. Methods A …

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Aberrant topology of the default mode network is associated with phosphatidylcholine and triglyceride levels in major depressive disorder

Yizhou Ma, Xin-Yu Wang, Wen-Liang Wang, Jing Zhang et autres

BACKGROUND: The default mode network (DMN) is associated with lipid metabolism. Patients with major depressive disorder (MDD) exhibit concurrent abnormal topological properties of the DMN and dysregulated lipid metabolism. However, there are no studies investigating the mechanisms underlying the associations between these …

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Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou et autres

Engineering antibodies to elicit antibody-dependent cell-mediated cytotoxicity (ADCC) can be used to eliminate target cells. Here, we described how single domain VHH arms on a bispecific antibody (BsAb) format can be engineered to modulate cell binding and ADCC activity. The BsAbs, comprising …

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Author response for "Engineering tandem VHHs to target different epitopes to enhance antibody-dependent cell-mediated cytotoxicity"

Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou et autres

Vertebral rotation as a predictor of residual deformity following scoliosis correction in spinal muscular atrophy: a retrospective analysis

Chen‐Yu Hung, Pin-Yi Tu, Wen‐Chen Liang, Cheng‐Chang Lu et autres

This study investigated the impact of preoperative vertebral rotation (VR) on the surgical outcomes in spinal muscular atrophy (SMA) scoliosis. A retrospective analysis of 27 SMA patients (mean age 13.4 ± 4.3 years) who underwent scoliosis surgery between 2015 and 2019 was …

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Author response for "Engineering tandem VHHs to target different epitopes to enhance antibody-dependent cell-mediated cytotoxicity"

Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou et autres

Two novel variant allele of the RHD gene detected in two Chinese blood donors with the RHD negative phenotype

Qiuhua Mo, Xuejun Liu, Limin Chen, Baoren He

BACKGROUND: The D antigen is the most clinically important antigen in the Rh system due to its high immunogenicity and being the main cause of hemolytic disease of the foetus and newborns (HDFN). High polymorphism of the RHD gene implicates that new …

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Reintroduction training is instrumental in restoring the oral microbiota of giant pandas from “captivity” to “wildness”

Rui Ma, Yu Xiang, Chong Huang, Fei Xue et autres

Reintroduction programs aim to restore wild populations, yet success is challenged by host microbiome adaptation to natural environments. Here, we characterized the oral microbiota of giant pandas undergoing pre-release training, comparing them to captive and wild conspecifics, to assess training-induced microbial shifts. …

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Development of a Radiomic-clinical Nomogram for Prediction of Survival in Patients with Nasal Extranodal Natural Killer/T-cell Lymphoma

Limin Chen, Zhao Wang, Xiaojie Fang, Mingjie Yu et autres

INTRODUCTION: An accurate and reliable prognostic model for Nasal Extranodal Natural Killer/T-cell Lymphoma (ENKTL) is critical for survival outcomes and personalized therapy. Currently, there is no Magnetic Resonance Imaging (MRI)- based radiomics analysis in the prognosis model for nasal ENKTL patients. OBJECTIVE: …

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Author response for "Engineering tandem VHHs to target different epitopes to enhance antibody-dependent cell-mediated cytotoxicity"

Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou et autres

Cyantraniliprole resistance in Tuta absoluta: selection, comparative transcriptomes, and nanocarrier-mediated RNAi studies

Farman Ullah, Hina Gul, Limin Chen, Zhi‐Jun Zhang et autres

The tomato leaf miner Tuta absoluta (Meyrick) is an important invasive tomato pest that causes serious economic losses worldwide.Cyantraniliprole, a second-generation anthranilic diamide insecticide, has been widely used against insect pests, including T. absoluta.In this study, a cyantraniliprole-resistant strain (CyanRS) exhibiting 23.9-fold …

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Global Burden and Trends of Acute Hepatitis C From 1990 to 2021: An Analysis Based on the 2021 Global Burden of Disease Study

Xinwei Wang, Xipeng Yan, Baoren He, Bin Li et autres

Acute hepatitis C (AHC) represents a considerable challenge to global public health, although direct-acting antiviral (DAA) therapy has substantially improved therapeutic outcomes for hepatitis C virus infection. Data were exclusively obtained from the 2021 Global Burden of Disease (GBD) study, which examined …

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