Chong Liu

Intelligent anatomy of spinal tuberculosis: region-specific performance analysis of a deep learning model based on multi-center CT axial images

Sen Mo, Chong Liu, Jiang Xue, J Q Chen et autres

Objective To solve the problems of insufficient model generalization ability and unclear influence of anatomical regional differences in the intelligent diagnosis of spinal tuberculosis, and to construct a multi-center CT deep learning model.Method This study adopted a retrospective multi-center design and collected …

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Clinical Practice Guideline for Spontaneous Isolated Superior Mesenteric Artery Dissection (2025 Edition)

Jin Ling, Jinjian Sun, Yuhang Hou, Mingwei Wu et autres

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Long-term ovarian function risks associated with combined oral contraceptive administration in polycystic ovary syndrome: multisource data integration and protective mechanisms of metformin

Jing Li, Jiajia Wei, Chong Liu, Ping He et autres

BACKGROUND: Polycystic ovarian syndrome (PCOS) is a prevalent endocrine disorder in women of reproductive age. Furthermore, the potential risks of long-term use of combined oral contraceptives (COCs) on ovarian reserve function remain unclear. We aimed to assess the association systematically between COC …

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Endoscopic‐Assisted Posterior Atlantoaxial Fusion: Technical Innovation and Clinical Experience

Jichong Zhu, Chengqian Huang, Jiang Xue, J Q Chen et autres

BACKGROUND: Atlantoaxial instability or dislocation requires reliable posterior stabilization and fusion to prevent neurological deterioration. Although conventional Goel-Harms posterior fixation provides effective biomechanical stability, it usually requires extensive posterior cervical muscle dissection and may be associated with substantial blood loss, postoperative axial …

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The tumor-suppressive function of the unique H domain of FCGBP and its potential as a therapeutic target in colorectal cancer

Qiao Liu, Hong-ying Jiao, Yuan Yuan Wang, Liao-Liao ZHU et autres

BACKGROUND: Colorectal cancer (CRC) is a major global health issue, characterized by high incidence and mortality rates. This study aims to further elucidate the function of H domain of Fc fragment of IgG binding protein (HFCGBP), as a candidate tumor suppressor gene, …

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Lumbar-sacral giant sparganosis presenting as an intradural mass

Jiarui Chen, Xinli Zhan, Chengqian Huang, Mingbo Wang et autres

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The expanding role of Furin in human Disease: A comprehensive review

Xinyang Li, Chong Liu, Haidi Hu

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Monocyte/macrophage-derived NLRP3 Promotes the Onset and Progression of Ankylosing Spondylitis Via the NOD-like Receptor Pathway

Jiarui Chen, Chengqian Huang, Tianyou Chen, Sitan Feng et autres

BACKGROUND AND OBJECTIVES: Ankylosing spondylitis (AS) is a chronic immune-mediated inflammatory disease primarily affecting the axial skeleton. Despite significant advances, its pathogenic mechanisms remain unclear, posing challenges to early diagnosis and effective treatment. This study aims to elucidate the pathogenic pathways of …

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Comprehensive Economic Analysis of Healthcare Costs in Ankylosing Spondylitis: Treatment Strategies and Socioeconomic Implications

Xiaopeng Qin, Zhuo Chen, Jie Ma, Yuhang Luo et autres

BACKGROUND: Ankylosing spondylitis (AS) is a chronic inflammatory disorder that imposes a significant economic burden through high healthcare costs. Prior studies have explored AS-related expenditures, but a comprehensive analysis of cost-related factors is lacking. This study aims to fill this gap. METHODS: …

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Using multiple machine learning algorithms to predict spinal cord injury in patients with cervical spondylosis: a multicenter study

Zhongxian Zhou, Sitan Feng, Xiaobo Zhou, Jing Yu et autres

Degenerative cervical spondylosis, a chronic and progressive condition, has a considerable impact on global health. Spinal cord injury, a severe sequela of this disease, can result from this disease. Machine learning (ML) has emerged as a valuable tool for medical data analysis, …

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Multi‐Omics Dissection of TIMP1 in Monocytes/Macrophages Reveals Pathogenic Mechanisms and Therapeutic Opportunities in Ankylosing Spondylitis

Jiarui Chen, Chengqian Huang, Jiang Xue, Zhongxian Zhou et autres

The pathogenesis of ankylosing spondylitis (AS) remains unclear, and its treatment poses significant challenges. This study aims to elucidate the underlying mechanisms of AS and explore potential therapeutic targets. We conducted a comprehensive multi-omics analysis, integrating proteomics, miRNA profiling, and single-cell sequencing …

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Anatomy Analysis of C5 CT Images in Children Aged 1–14 Years

Jiarui Chen, Chengqian Huang, Chenxing Zhou, Hua Jiang et autres

OBJECTIVE: There is a lack of large-scale anatomical studies on children's C5 vertebrae, and experience with posterior cervical spine fixation surgery in children is limited, posing challenging clinical issues. This study aims to investigate the size, morphology, and developmental growth of the …

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