Dai Li

Determination of 7 food additives in prepared pork dishes by gel permeation chromatography cleanup coupled with ultra-high performance liquid chromatography-tandem mass spectrometry

Dai Li, WANG Chunlei, Bingbing Li, HUANG Zhenzhen et autres

ObjectiveA method was developed for the simultaneous determination of seven food additives in prepared pork dishes using gel permeation chromatography cleanup coupled with ultra-high performance liquid chromatography-tandem mass spectrometry.MethodsSamples were extracted using ultrasound-assisted extraction with acetonitrile containing 0.2% formic acid. The extracts …

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Job stress among home-visiting nurses in China: direct, moderating, and mediating pathways based on the job demands-resources model

Dai Li, Jiao Xiong, Yujiao Sun, Suyu Wei

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Brain-derived exosomes from aged mice accelerate cognitive decline in repeated mild traumatic brain injury by activating neuronal Tnfrsf25

Y. N. Liu, Shan Liu, Bo Yan, Zhenyu Yin et autres

Aging increases vulnerability to cognitive decline after repetitive mild traumatic brain injury (rm-TBI), yet mechanisms linking age-related factors to neurodegeneration remain poorly understood. This study investigated how brain-derived exosomes from aged mice (A-Exo) worsen rm-TBI outcomes. In a murine rm-TBI model, intranasal …

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Supplementary enteral and parenteral nutrition in neoadjuvant therapy for gastric cancer patients: Necessity, application, and prospects

Xu Luo, Qian Wang, Xue Ding, Dai Li et autres

1p-Enh-regulated CYP4B1 alleviates NNK-induced heart failure and lung cancer via the STAT3 pathway

Dai Li, J. F. Hu, Yang Ye, Bingjun Qian et autres

Heart failure (HF) and lung cancer (LC) often coexist, yet their shared molecular mechanisms are unclear. We analyzed transcriptome data from the NCBI Gene Expression Omnibus (GEO) database (GSE141910, GSE57338) to identify 346 HF‑related differentially expressed genes (DEGs), then combined weighted gene …

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Identification of novel cholesterol metabolism-related biomarkers for thyroid cancer to predict the prognosis, immune infiltration, and drug sensitivity

Xixi Li, Pei Shi, Feifei Wu, Dai Li

BACKGROUND: With the sharp increase in the incidence of papillary thyroid carcinoma (PTC), the disease-specific survival rate has not improved significantly. Cholesterol metabolism plays a crucial role in tumor proliferation, regulation of tumor immune escape, and tumor drug resistance. However, there are …

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S1PR3 inactivation aggravates cerebrovascular endothelial cell permeability mediated by cPLA2 and stat3 phosphorylation under oxidative stress

Junyu Mu, Lin‐Quan Ge, Dai Li, Jing Zhang

Sphingosine-1-phosphate receptor-3 (S1PR3) has been implicated in the maintanence of cerebrovascular integrity during cerebral ischemia. This study aimed to elucidate the impact of S1PR3 inactivation on oxidative stress-induced cerebrovascular endothelial cell permeability and to explore the potential mechanisms. In bEnd3 cells, blockade …

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A Nomogram for Predicting In‐Hospital Mortality in Critically Ill Patients With Myocardial Infarction and Atrial Fibrillation

R. Duan, Ziwei Yang, Dai Li, Xu Tingting et autres

BACKGROUND: Myocardial infarction (MI) and atrial fibrillation (AF), a common complication during hospitalisation of critically ill MI patients, have a complex and close bidirectional relationship, and the two frequently occur together. AIM: To develop a nomogram to predict the risk of in-hospital …

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Preclinical evaluation of a fluorine-18 labeled transthyretin small interfering RNA transfection platform as an imaging probe for liver fibrosis

Dai Li, Fanlei Kong, Qiyong Guo

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Exploring the causal relationship between PAH and some autoimmune diseases using bidirectional Mendelian randomization analyses

Huilin Lian, Youjie Zeng, Ren Guo, Dai Li

The causal association between pulmonary arterial hypertension (PAH) and autoimmune diseases remains uncertain. This study aimed to assess the causal associations between PAH and autoimmune diseases using bidirectional Mendelian randomization (MR) analyses. Genome-wide association summary statistics for PAH, asthma, myasthenia gravis, rheumatoid …

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Safety, Tolerability, Pharmacokinetics, and Effects of Gene Polymorphisms on Furaprevir (TG-2349), a Novel Hepatitis C Inhibitor: A Randomized Phase I Study

Su‐Mei Xu, Ying–Jun Angela Zhang, Li‐Wen Chang, Cheng‐Yuan Tsai et autres

INTRODUCTION: The purpose of our study was to evaluate the safety, tolerability, and pharmacokinetics of furaprevir, a new highly selective hepatitis C virus NS3/4A protease inhibitor. METHODS: The study was divided into 2 parts: part A (single ascending dose study [SAD]) and …

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Diuretic effect and renal function impact of dapagliflozin in hospitalized patients with HFrEF.

Shanshan Li, Youxuan Wu, Xiaolei Hu, Xiaoxiao Mao et autres

OBJECTIVES: Patients with heart failure with reduced ejection fraction (HFrEF) often require diuretics during hospitalization to alleviate fluid retention and improve prognosis. However, the diuretic efficacy and renal impact of dapagliflozin in this population remain unclear. This study aims to investigate the …

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