Jiyuan Liu

Metabolic compensation via gluconeogenesis explains the non-essentiality of glycogen phosphorylase as an insecticidal target in Plutella xylostella

Yifei Zhou, Yanqi Kang, Yan Liu, Ruichi Li et autres

Glycogen phosphorylase (GP) catalyzes the rate-limiting step of glycogenolysis and occupies a central position in insect carbohydrate metabolism, supplying precursors for chitin biosynthesis. Acyl urea compounds structurally related to benzoylphenylurea (BPU) insecticides are potent inhibitors of mammalian GP, raising the question of …

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Metabolic compensation via gluconeogenesis explains the non-essentiality of glycogen phosphorylase as an insecticidal target in Plutella xylostella

Yi Zhou, Yanqi Kang, Liu Y, Ruichi Li et autres

Benzoylphenylurea (BPU) insecticides disrupt insect chitin formation, yet their molecular target is debated. Although resistance-associated mutations map to the Chitin Synthase (CHS) gene, direct inhibition of CHS has not been demonstrated. Given the structural similarity of BPUs to mammalian glycogen phosphorylase (GP) …

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Metabolic compensation via gluconeogenesis explains the non-essentiality of glycogen phosphorylase as an insecticidal target in Plutella xylostella

Yi Zhou, Yanqi Kang, Liu Y, Ruichi Li et autres

Glycogen phosphorylase (GP) catalyzes the rate-limiting step of glycogenolysis and occupies a central position in insect carbohydrate metabolism, supplying precursors for chitin biosynthesis. Acyl urea compounds structurally related to benzoylphenylurea (BPU) insecticides are potent inhibitors of mammalian GP, raising the question of …

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The molecular mechanisms mediating a trade-off between insecticide resistance and development in an invasive pest

Xueqing Yang, Chao Hu, Yuxi Liu, Xin Yang et autres

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Metabolic compensation via gluconeogenesis explains the non-essentiality of glycogen phosphorylase as an insecticidal target in Plutella xylostella

Yifei Zhou, Yanqi Kang, Ying Liu, Ruichi Li et autres

Abstract Glycogen phosphorylase (GP) catalyzes the rate-limiting step of glycogenolysis and occupies a central position in insect carbohydrate metabolism, supplying precursors for chitin biosynthesis. Acyl urea compounds structurally related to benzoylphenylurea (BPU) insecticides are potent inhibitors of mammalian GP, raising the question …

cn (code pays fourni par la source)

Universal physical principles of protein structural genesis emerge in language-model representation space

Liu Chuanyang, Jiyuan Liu, Xinyuan Qiu, Xiaomin Wu et autres

Abstract Protein structure is usually treated as the endpoint of sequence by most AI models, yet its true biological emergence is a process of ordered change, whose logic remains hidden in opaque black box. ProtGenesis creates a bidirectional mirror world: it maps …

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From Field Overexpression to Biochemical Function: PxCYP6B4-Mediated Hydroxylation Confers Pyrethroid Resistance in Plutella xylostella

Zhuoda Liu, Yifei Zhou, Dongliang Wang, Ruichi Li et autres

The rapid evolution of insecticide resistance threatens global food security, with cytochrome P450-mediated detoxification representing a key adaptive mechanism in insects. However, direct biochemical evidence linking specific P450s to pyrethroid metabolism in Plutella xylostella remains limited. Here, we investigated the molecular basis …

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What is the future direction for the treatment of Parkinson’s disease: Deep brain stimulation or stem cell transplantation therapy?

Jun Wang, Huaiyuan Wang, Jiyuan Liu, Chen Zhu et autres

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Synergistic boosting of insecticide efficacy by the phytochemical (−)-(S)-palasonin: A cross-class enhancement for aphid control with laboratory-field concordance

Jiyuan Liu, Pengyu Chang, Ran Yin, Dongliang Wang et autres

Aphids impose chronic yield and quality losses in intensive production systems while escalating resistance erodes the reliability of conventional insecticides. Plant-derived actives from industrial crops offer renewable chemistry but often require formulation strategies to ensure robust field performance. Here we evaluate (−)-(S)-palasonin …

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Cross-tissue deep profiling of redox proteome in obese mice using enhanced resin-assisted capture and data-independent acquisition

Jiyuan Liu, Xinbo Jiang, Yunyu Li, Liye Shen et autres

Cysteine thiol modification plays a critical role in the precise regulation of the cellular redox state. Existing redox proteomic methodologies are often limited by their efficiency, complexity, and cost. To overcome these limitations, we developed and synthesized a series of novel enrichment …

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ATMLP Enhances Radioresistance in Non-Small Cell Lung Cancer through AKT-Mediated Lipid Droplet Accumulation

Yingchu Dai, Wanyi Wu, Tingyu Jiao, Lu Hou et autres

Radioresistance remains a critical barrier to successful radiotherapy in non-small cell lung cancer (NSCLC). ATMLP, a mitochondrial-localized peptide encoded by lncRNA AFAP1-AS1, has been previously associated with tumor progression. In this study, we uncover a previously unrecognized role of ATMLP in promoting …

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Unraveling the role of PxGSTD5 in pyrethroids metabolism: a molecular and biochemical investigation of resistance mechanisms in Plutella xylostella

Xinyu Li, Pengyu Chang, Dongliang Wang, Yifei Zhou et autres

Plutella xylostella, a major pest of cruciferous crops, has rapidly evolved resistance to pyrethroid insecticides, posing a significant threat to sustainable agriculture. Among the various resistance mechanisms, glutathione S-transferases (GSTs) play a pivotal role in the detoxification of xenobiotics. However, the molecular …

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