Yingchu Dai

Triglyceride enhancs NSCLC metastasis via lipid β-oxidation by RhoA-driven cytoskeletal remodeling in ECM-constrained microenvironments

Yingchu Dai, Yufan Ling, Lu Hou, Tianqi Yang et autres

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ATMLP Enhances Radioresistance in Non-Small Cell Lung Cancer through AKT-Mediated Lipid Droplet Accumulation

Yingchu Dai, Wanyi Wu, Tingyu Jiao, Lu Hou et autres

Radioresistance remains a critical barrier to successful radiotherapy in non-small cell lung cancer (NSCLC). ATMLP, a mitochondrial-localized peptide encoded by lncRNA AFAP1-AS1, has been previously associated with tumor progression. In this study, we uncover a previously unrecognized role of ATMLP in promoting …

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Unraveling cellular dynamic changes in tumor evolution induced by long-term low dose-rate radiation

Wanshi Li, Weiwei Pei, Yiwei Wang, Jing Nie et autres

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Synthesis, preclinical assessment, and first-in-human study of [18F]d4-FET for brain tumor imaging

Lu Hou, Zhiyong Chen, Fanfan Chen, Lianghe Sheng et autres

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Retraction Note: The long noncoding RNA CRYBG3 induces aneuploidy by interfering with spindle assembly checkpoint via direct binding with Bub3

Ziyang Guo, Yingchu Dai, Wentao Hu, Yongsheng Zhang et autres

The mice shown in Figure 5H (panel Ctrl) appear to be the same as the mice shown in Figure 5H (panel LNC CRYBG3+sh Bub3)

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X-ray-downregulated nucleophosmin induces abnormal polarization by anchoring to G-actin

Yingchu Dai, Yongduo Yu, Jing Nie, Ke Gu et autres

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The Tumorigenic Effect of lncRNA AFAP1‐AS1 is Mediated by Translated Peptide ATMLP Under the Control of m6A Methylation

Hailong Pei, Yingchu Dai, Yongduo Yu, Jiaxin Tang et autres

Abstract Long noncoding RNAs (lncRNAs) in eukaryotic transcripts have long been believed to regulate various aspects of cellular processes, including carcinogenesis. Herein, it is found that lncRNA AFAP1‐AS1 encodes a conserved 90‐amino acid peptide located on mitochondria, named lncRNA AFAP1‐AS1 translated mitochondrial‐localized …

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Long Non-Coding RNA CRYBG3 Promotes Lung Cancer Metastasis via Activating the eEF1A1/MDM2/MTBP Axis

Anqing Wu, Jiaxin Tang, Ziyang Guo, Yingchu Dai et autres

The occurrence of distant tumor metastases is a major barrier in non-small cell lung cancer (NSCLC) therapy, and seriously affects clinical treatment and patient prognosis. Recently, long non-coding RNAs (lncRNAs) have been demonstrated to be crucial regulators of metastasis in lung cancer. …

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RETRACTED ARTICLE: The long noncoding RNA CRYBG3 induces aneuploidy by interfering with spindle assembly checkpoint via direct binding with Bub3

Ziyang Guo, Yingchu Dai, Wentao Hu, Yongsheng Zhang et autres

Aneuploidy is a hallmark of genomic instability that leads to tumor initiation, progression, and metastasis. CDC20, Bub1, and Bub3 form the mitosis checkpoint complex (MCC) that binds the anaphase-promoting complex or cyclosome (APC/C), a crucial factor of the spindle assembly checkpoint (SAC), …

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Radiation Exposure–Induced Changes in the Immune Cells and Immune Factors of Mice With or Without Primary Lung Tumor

Shuxian Pan, Jingjie Wang, Anqing Wu, Ziyang Guo et autres

Recent studies have demonstrated that radiation activates in situ antitumor immunity and consequently induced a synergistic effect of radiotherapy and immunotherapy. However, studies related to radiation-induced changes in immune system of tumor-bearing mice are limited, which are of great significance to improve …

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Progress on the fundamental biological studies for tumor therapy with heavy particles

Yingchu Dai, Jiade Lu, Guangming Zhou

Due to its unique physical and biological advantages, heavy ion beam has great advantages as tumor radiotherapy ray. Tumor therapy with heavy particles has achieved outstanding clinical outcome and is of the potential to become the most advanced radiotherapy in this century. …

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Genome-Wide Profiling of the Toxic Effect of Bortezomib on Human Esophageal Carcinoma Epithelial Cells

Nannan Ao, Yingchu Dai, Qianping Chen, Yang Feng et autres

OBJECTIVES: Bortezomib has been widely used to treat multiple myeloma and other hematological malignancies. However, not much is known about its effect on solid tumors. The aim of this study was to study the effect of Bortezomib on human esophageal cancer cell …

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