Yuzhu Wang

Molecular Diagnosis and Pathway Convergence in Neurodevelopmental Disorders: An Integrative Genomic Study of 1,011 Patients

Fengyu Che, Xinchao Cheng, Xiaoling Tie, Yuzhu Wang et autres

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Electrophysiological stimulation is associated with improved lower-extremity venous hemodynamics and postoperative recovery following laparoscopic nephrectomy

Yuwen He, Lie Lin, Ningning Tian, Jiamei Chen et autres

Background Venous thromboembolism (VTE) is a common and potentially serious complication following laparoscopic nephrectomy. Conventional preventive measures are limited by bleeding risk and poor compliance. Electrophysiological stimulation therapy has emerged as a non-invasive approach to improve venous circulation, but its perioperative efficacy …

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Bioactive glutathione-modified carboxymethyl cellulose hydrogels as levofloxacin delivery platforms for the Staphylococcus aureus-infected wounds management

Tianbao Wang, Yaqin Yang, Ya Zhuo, Aihui Li et autres

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Effects of improved creative play interventions on social communication, behavioral, and cognitive function in children with autism spectrum disorder: a randomized controlled trial

Mengchang Zhang, Mengzi Zhao, Yanfang Zhang, Fang Gao et autres

Background Children with autism spectrum disorder (ASD) often exhibit deficits in social communication, repetitive behaviors, and cognitive delays. Play-based interventions have shown effectiveness in the treatment of ASD. This study aims to investigate the impact of improved creative play interventions combined with …

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Heme cascade-triggered nanovesicles for myocardial ischemic core delivery

Hui Chen, Ying Yang, Mirenuer Aikebaier, Hao Wang et autres

Myocardial ischemia-reperfusion injury (MIRI) remains a significant therapeutic challenge due to insufficient targeted drug delivery. Recognizing heme as a key endogenous signal that has yet to be utilized in delivery systems, we designed the first heme-responsive nanovesicle (DecAS-PC@NM) for lesion-specific therapy through …

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Identification of an isg15 gene in Nile tilapia (Oreochromis niloticus) and analysis of its role in immune response modulation

Yuzhu Wang, Wenxin Tang, Guichun Wu, Jiaojiao He et autres

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Comparative inhibitory effects of phillyrin and phillygenin on elastase: mechanisms and therapeutic potential

Wenhui Zhang, Jinfeng Fu, Hongliu Yao, yongxue Li et autres

Elastase, a serine protease, has been implicated in chronic obstructive pulmonary disease and systemic inflammatory response syndrome. In this study, we evaluated the effects of phillyrin and phillygenin, 2 major Forsythia lignans, on elastase inhibition. Both compounds exhibited competitive inhibition, as confirmed …

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Haplotype-resolved genome assembly of the colored calla lily (Zantedeschia elliottiana) provides new insights into the evolution of the family Araceae

Yuzhu Wang, Tuo Yang, Di Wang, Rongxin Gou et autres

Abstract The colored calla lily, a member of the genus Zantedeschia in the Araceae family native to South Africa, is a valuable ornamental plant. However, the lack of a high-quality genome has hindered genetic analysis and the identification of key trait-related genes. …

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Research advances in the antimicrobial activity of natural product-antimicrobial peptide (AMP) mimic conjugates

Ayue Kang, Yue Tian, Yuzhu Wang, Xinhui Li et autres

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Overexpression of IL-8 augments the susceptibility to a hyperinflammatory phenotype in pediatric acute respiratory distress syndrome and correlates with adverse outcomes: a retrospective two-center study conducted in northwest China

Yuzhu Wang, W D Wang, Zhe Lv, Haitong Wu et autres

Background The prognosis of acute respiratory distress syndrome (ARDS) varies with inflammatory responses. ARDS patients with a hyperinflammatory phenotype usually have worse alveolar epithelial injury and vascular endothelial injury than those carrying a hypoinflammatory phenotype. Activated neutrophils recruited and migrated in the …

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LINC00973/DTX3L Axis Promotes Non‐Small Cell Lung Cancer Progression and Serves as a Therapeutic Target

Yanke Chen, Qian Yu, Jiayuan Shi, Yuzhu Wang et autres

Long non-coding RNAs (lncRNAs) constitute a critical class of regulatory molecules involved in cancer biology and play pivotal roles in tumor initiation and progression. Nevertheless, the biological functions of many newly identified lncRNAs in non-small cell lung cancer (NSCLC), as well as …

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The green leaf volatile Z-3-Hexenyl acetate improves drought stress resistance of tea plants via regulating the phenylpropanoid biosynthesis pathway

Jiazhi Shen, Yaozong Shen, Yuchen Li, Litao Sun et autres

• Z-3-Hexenyl acetate (Z-3-HAC) enhances drought tolerance in tea plants. • Z-3-HAC reduces MDA and soluble sugar accumulation of tea plant under drought stress. • Genes in phenylpropanoid biosynthesis pathway show tendency to synthesize S-lignin. • F5H was tentatively identified as the …

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