Overexpression of IL-8 augments the susceptibility to a hyperinflammatory phenotype in pediatric acute respiratory distress syndrome and correlates with adverse outcomes: a retrospective two-center study conducted in northwest China
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Background The prognosis of acute respiratory distress syndrome (ARDS) varies with inflammatory responses. ARDS patients with a hyperinflammatory phenotype usually have worse alveolar epithelial injury and vascular endothelial injury than those carrying a hypoinflammatory phenotype. Activated neutrophils recruited and migrated in the lung tissue are responsible for stimulating the progression of ARDS. Interleukin-8 (IL-8), as an inflammatory factor, further aggravates lung damage in ARDS. Methods This was a retrospective study involving 135 ARDS children admitted in two pediatric hospitals in northwest China. They were either classified into mild, moderate and severe groups based on the oxygenation index (OI) or oxygenation saturation index (OSI) within 4-h invasive mechanical ventilation on admission, or the survival and non-survival groups based on the 28-day mortality. Demographic and clinical data were analyzed. Risk factors for the prognosis of PARDS were identified by logistic regression. The correlation of IL-8 level with the identified risk factors was analyzed. Prognostic potential of IL-8 was determined by plotting the receiver operating characteristic (ROC) curves. Results IL-8, RAGE, Ang-2, ICAM-1 and SP-D were independent risk factors for the mortality of PARDS. They were significantly higher in the non-survival group than the survival group, showing a potential in predicting mortality in PARDS, especially in the combination ( P < 0.05). IL-8 was positively correlated with RAGE, Ang-2, ICAM-1 and SP-D in children with ARDS ( P < 0.05). Conclusion IL-8 is overexpressed in children with ARDS, showing a prognostic potential particularly in combination with RAGE, Ang-2, ICAM-1 and SP-D in PARDS.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Overexpression of IL-8 augments the susceptibility to a hyperinflammatory phenotype in pediatric acute respiratory distress syndrome and correlates with adverse outcomes: a retrospective two-center study conducted in northwest China
- Date Crossref
- 03/02/2026
- Éditeur
- Frontiers Media SA
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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First Affiliated Hospital of Xi'an Jiaotong University Department of Neonatology pays non établi dans la noticeÉtablissement de santé
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Second Affiliated Hospital of Xi'an Jiaotong University pays non établi dans la noticeÉtablissement de santé
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Xi’an Children’s Hospital pays non établi dans la noticeÉtablissement de santé
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Gansu Provincial Maternal and Child Health Hospital pays non établi dans la noticeÉtablissement de santé
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Xi'an Jiaotong University Pediatric Intensive Care Unit pays non établi dans la noticeUniversité ou école supérieure
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Gansu Provincial Maternity and Child-care Hospital Pediatric Intensive Care Unit pays non établi dans la noticeÉtablissement de santé
Department of Neonatology — First Affiliated Hospital of Xi'an Jiaotong University, Second Affiliated Hospital of Xi'an Jiaotong University et Xi’an Children’s Hospital, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.