Jie Cao

Nanoscale Confined Tribo‐Ion‐Photonics for Ultrahigh‐Resolution Imaging

Ziyue Wang, Tianzhao Bu, Jie Cao, Ruifei Luan et autres

Interactive sensing displays with ultrahigh resolution are critically important for next-generation human-machine interfaces and near-eye display technologies, yet their development has been hindered by fabrication and material limitations. Here, a nanoscale confined tribo-ion-photonic device has been proposed, consisting of a counterion-electromigration-confined ion-gel, …

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Electroacupuncture therapy and bone cancer pain relief: experimental study on analgesic mechanisms in rats

Yànhuá Lǐ, Fangfei Li, Caizhi Xiao, Jie Cao et autres

Background Bone cancer pain is a common complication of advanced malignant tumors.Chemotherapeutic drugs, regardless of their origin or type, are often associated with various adverse effects such as gastrointestinal toxicity, immune suppression, and acquired drug resistance, which can compromise patients’ quality of …

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Chinese patients receiving ICS/LABA or LAMA-containing asthma therapy characterisation: Retrospective cohort study

Zhiliu Tang, Xin Li, Jie Cao, I‐Ming Chen et autres

Rationale: Asthma is a heterogeneous disease with 2.2% prevalence in China. We detailed characteristics, clinical burden and treatment patterns of patients with asthma treated with ICS/LABA or LAMA-containing therapy. Methods: Retrospective cohort study of adults with asthma identified in the Tianjin electronic …

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Rentosertib, a generative AI-discovered TNIK inhibitor improves lung function in IPF patients

Zuojun Xu, Ping Wang, Jie Cao, Chunting Tan et autres

Rentosertib, a novel AI-generated TNIK inhibitor, was tested in a 12-week phase 2a randomized, double-blind, placebo-controlled trial of 71 idiopathic pulmonary fibrosis (IPF) patients. Participants received placebo, 30mg once daily (QD), 30mg twice daily (BID), or 60mg QD. Baseline demographics and lung …

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Asthma healthcare burden with ICS/LABA or LAMA-containing therapies: Chinese retrospective cohort study

Zhiliu Tang, Xin Li, I‐Ming Chen, Stephen G. Noorduyn et autres

Rationale: There is limited data available to quantify the burden of asthma in China associated with ICS/LABA or any LAMA-containing asthma therapies. We assessed the healthcare burden for Chinese patients with asthma. Methods: Retrospective cohort study in adult patients with asthma prescribed …

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Chebulinic acid shields Villin 1 from covalent attack to mitigate Euphorbia fischeriana enterotoxicity: A basis for safer anti-ascites therapy

Hang Wang, Jie Cao, Sheng Li, Ruolan Yang et autres

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Arrhythmia Classification Based on Distribution Encoding Network with Biomedical Radar

Jie Cao, Wen Li, Shuqin Dong, Min Tang et autres

With the aid of high-precision biomedical radar, vital signs can be measured with micrometer-level accuracy, paving the way for a series of innovative techniques in cardiac activity monitoring. This paper presents an exploratory experiment conducted in collaboration with cardiologists, during which ECG …

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Red cabbage exosome-like nanoparticles inhibited LPS-induced inflammation and oxidative stress in RAW264.7 cells

Jie Cao, Jing Zhang, Ling Yan, Changhong Liu et autres

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Inhibiting Pyk2/Src expression by miR-23b-3p suppressed liver cancer stem cell function and hepatic carcinoma progression

Meng Sha, Jiang Zhang, Jinkai Liu, Xuan Qu et autres

Liver cancer stem cells (LCSCs) are critical drivers of metastasis and chemoresistance in hepatocellular carcinoma (HCC). Proline-rich tyrosine kinase 2 (Pyk2) has been implicated in tumor progression, but its role in LCSC stemness and HCC malignancy remains unclear. This study explores the …

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A generative AI-discovered TNIK inhibitor for idiopathic pulmonary fibrosis: a randomized phase 2a trial

Zuojun Xu, Feng Ren, Ping Wang, Jie Cao et autres

Despite substantial progress in artificial intelligence (AI) for generative chemistry, few novel AI-discovered or AI-designed drugs have reached human clinical trials. Here we present the results of the first phase 2a multicenter, double-blind, randomized, placebo-controlled trial testing the safety and efficacy of …

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Microwave Bio-Radar Monitoring of Gene-controlled Activity Changes of Normal and Mouth-breathing Rats

Jie Cao, Shuqin Dong, Sitong Li, Xiaoling Wang et autres

In this paper, microwave biomedical radar is used for the first time to monitor rat activity levels in an experiment investigating their biological rhythms. Cameras are commonly used for activity monitoring, but the images they capture require considerable computational resources and can …

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Eosinophil Levels and Testing Rates of Related Inflammatory Biomarkers Among Chinese Patients With Moderate-to-Severe Asthma: Baseline Analysis of a Real-world, Multicenter Study

Li Yu, Zhongmin Qiu, Jing He, Yirong Jiang et autres

Abstract Rationale Eosinophilic asthma is a common phenotype of severe asthma characterized by elevated eosinophil (EOS) levels, and it is associated with a higher risk of exacerbations. Regular tests of EOS levels and related inflammatory biomarkers are crucial for guiding treatment approach …

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