Yadong Liu

RNA-seq Analysis Reveals Neuroimmune Remodeling and NTSR1-Related Neuroactive Signatures After Combined rTMS and Press-Tack Needle Stimulation in TBI Rats

Zhong Li, Jing Fu, Ying Qian, Jianlin Pu et autres

cn (code pays fourni par la source)

HitSV call results for "Structural variant detection across sequencing technologies"

Gaoyang Li, Yadong Liu, Anqi Zhang, Xiaoyi Lin et autres

Data associated with the manuscript "Structural variant detection across sequencing technologies". HitSV models the interaction between genomic repetitiveness and structural-variant signature intensity to improve structural variant detection across sequencing technologies. The deposited files contain structural variant callsets generated by HitSV for the …

cn (code pays fourni par la source)

HitSV call results for "Structural variant detection across sequencing technologies"

Gaoyang Li, Yadong Liu, Anqi Zhang, Xiaoyi Lin et autres

Data associated with the manuscript "Structural variant detection across sequencing technologies". HitSV models the interaction between genomic repetitiveness and structural-variant signature intensity to improve structural variant detection across sequencing technologies. The deposited files contain structural variant callsets generated by HitSV for the …

cn (code pays fourni par la source)

Integrating chemical priors and physical laws to mitigate hallucinations in structure-based drug design

Zhongyu Liu, Yadong Liu, Yihang Zhou, Zhiyuan Liu et autres

Generative artificial intelligence has shown great promise in structure-based drug design (SBDD), yet existing models often suffer from a fundamental crisis of “structural hallucinations”, generating molecules with high binding scores that violate basic chemical principles or physical plausibility. Here we present DrugRPG, …

sg, cn (code pays fourni par la source)

DTCR: generating realistic, diverse, and epitope-specific T cell receptor sequences via a discrete diffusion model

Haoyan Wang, Tianyi Zang, Yadong Liu

T lymphocytes are central to adaptive immunity, utilizing clonally distributed T cell receptors (TCRs) to recognize peptide-major histocompatibility complex ligands with high specificity. The immense diversity and precise antigen recognition of TCRs are critical for mounting effective immune responses. However, conventional experimental …

cn (code pays fourni par la source)

cuteSV-OL: a real-time structural variation detection framework for nanopore sequencing devices

Weimin Guo, Yadong Liu, Yadong Wang

SUMMARY: Nanopore sequencing technology enables real-time sequencing and is widely used in rapid detection applications. However, in clinical scenarios, existing structural variant (SV) detection tools typically separate sequencing from computation, limiting their timeliness for clinical applications. To address this, we introduce cuteSV-OL, …

cn (code pays fourni par la source)

Author Correction: cuteFC: regenotyping structural variants through an accurate and efficient force-calling method

Tao Jiang, Shuqi Cao, Yadong Liu, Zhendong Zhang et autres

cn, hk (code pays fourni par la source)

Insights into efficient one-pot conversion of 5-hydroxymethylfurfural to 2,5-dicyanofuran via the synergistic 5Cu-VOx@CN/TEMPO catalyst system

Tong Sun, Mengyuan Huang, Yadong Liu, Zhong Zheng et autres

cn (code pays fourni par la source)

CKG-TPI: integrating collaborative knowledge graph with sequence interactions for TCR–peptide binding specificity

Yue Liu, Guohua Wang, Guohua Wang, Yadong Liu et autres

Accurately identifying interactions between T-cell receptors (TCRs) and peptides is a fundamental challenge in immunology, with significant implications for vaccine design and immunotherapy. While computational methods offer efficient alternatives to labor-intensive experimental screening, achieving robust and accurate TCR-peptide binding prediction remains a …

cn (code pays fourni par la source)

cuteFC: regenotyping structural variants through an accurate and efficient force-calling method

Tao Jiang, Shuqi Cao, Yadong Liu, Zhendong Zhang et autres

Long-read sequencing technologies have great potential for the comprehensive discovery of structural variations (SVs). However, accurate genotype assignment for SVs remains challenging due to unavoidable sequencing errors, limited coverage, and the complexity of SVs. Herein, we propose cuteFC, which employs self-adaptive clustering …

cn, hk (code pays fourni par la source)

Locoregional Immune Checkpoint Blockade and Remodeling of Lymph Nodes by Engineered Dendritic Cell‐Derived Exosomes for Suppressing Tumor Progression and Metastasis

Yizhen Wang, Xiaomin Guo, Jingya Qin, Yifan Xue et autres

Tumor-draining lymph nodes (TDLNs) are the primary sites of eliciting anti-tumor immunity, which play an important role in controlling tumor progression and metastasis. However, the immunosuppressive microenvironment of TDLNs propels the formation of pre-metastatic niche, in which the immunocytes are dysfunctional, and …

cn (code pays fourni par la source)

Aerobic oxidation of 5-hydroxymethylfurfural to 2,5-furandicarboxylic acid by modification of the crystalline structure of MnO2 for catalytic purposes

Wenbo Liao, Shibo Yang, Yadong Liu, Qing Yin et autres

cn (code pays fourni par la source)