Guo Zhang

Identification and functional validation of SPON2 as a novel biomarker for the diagnosis and prognosis in hepatocellular carcinoma

Wanrong He, Zehua He, Qingfeng Chen, Wei Lan et autres

Background: Hepatocellular carcinoma (HCC) is a major global health burden, with persistently low 5-year survival rates. The major clinical challenge in HCC lies in the lack of accurate biomarkers for early detection, prognostic evaluation, and prediction of tumor aggressiveness. This study aimed …

cn (code pays fourni par la source)

Author Correction: An orally available Mpro/TMPRSS2 bispecific inhibitor with potent anti-coronavirus efficacy in vivo

Huiping Shuai, Jingxin Qiao, Chaemin Yoon, Guo Zhang et autres

In the version of the article initially published, the “DMSO, TMP1” image in Fig. 5d was incorrect and has now been replaced in the HTML and PDF versions of the article. The original Fig. 5 is available as Supplementary information for comparison.

hk, cn, fr (code pays fourni par la source)

An orally available Mpro/TMPRSS2 bispecific inhibitor with potent anti-coronavirus efficacy in vivo

Huiping Shuai, Jingxin Qiao, Chaemin Yoon, Guo Zhang et autres

Coronaviruses have caused three major endemics in the past two decades. Alarmingly, recent identification of novel zoonotic coronaviruses that caused human infections suggests the risk of future coronavirus outbreak caused by spillover infection from animal reservoirs remains high. Therefore, development of alternative …

hk, cn, fr (code pays fourni par la source)

A deep learning model for structure-based bioactivity optimization and its application in the bioactivity optimization of a SARS-CoV-2 main protease inhibitor

Zhenyu Yang, Kai Wang, Guo Zhang, Yuanyuan Jiang et autres

Bioactivity optimization is a crucial and technical task in the early stages of drug discovery , traditionally carried out through iterative substituent optimization, a process that is often both time-consuming and expensive. To address this challenge, we present Pocket-StrMod, a deep-learning model …

cn (code pays fourni par la source)

An orally available Mpro/TMPRSS2 bispecific inhibitor with potent anti-coronavirus efficacy in vivo

Hin Chu, Huiping Shuai, Jingxin Qiao, Chaemin Yoon et autres

hk, cn (code pays fourni par la source)

PocketFlow is a data-and-knowledge-driven structure-based molecular generative model

Yuanyuan Jiang, Guo Zhang, Jing You, Hailin Zhang et autres

cn (code pays fourni par la source)