Lixia Feng

A rapid and sensitive method for the detection of Didymella pinodella in Pisum sativum

Haipeng Zhang, Wanfen Li, Fang Liu, Lixia Feng et autres

Abstract BACKGROUND Ascochyta blight (AB) is a major disease that severely constrains crop yield and quality, capable of causing losses up to 80%. The pathogens responsible for AB are included in a species complex, with Didymella pinodella being one of the main …

cn (code pays fourni par la source)

PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe

Wending Gao, Wenzhu Hu, D Tang, Xinxin Liu et autres

ABSTRACT Myocarditis, primarily induced by viral infection, lacks reliable non‐invasive imaging for early diagnosis. We developed a novel PET probe, 68 Ga‐DOTA‐linagliptin (abbreviated as 68 Ga‐linagliptin), which targets dipeptidyl peptidase‐4 (DPP4), to assess its potential in detecting myocarditis. Western blotting and immunostaining …

cn, us (code pays fourni par la source)

First Report of Fruit Rot of Snake Fruit (Salacca zalacca) Caused by Thielaviopsis euricoi Based on Morphological and Phylogenetic Analyses

Chenxi Shao, Mutao Wu, Lixia Feng, Xuan Yu et autres

Snake fruit (Salacca zalacca (Gaertner) Voss) is renowned for its taste and nutritional value; however, the snake fruit rot diseases caused by fungal pathogens can lead to significant economic losses. In this study, a fungal isolate was obtained from the rotten snake …

cn (code pays fourni par la source)

Mapping CSC‐Mediated Ovarian Cancer Chemoresistance via CXCR4‐PET to Guide Precision Cisplatin Re‐Sensitization Therapy

Lixia Feng, Simei Zhao, Zheng Wei, Wenwen Wang et autres

ABSTRACT Therapy targeting cancer stem cells (CSCs) has been proposed as a promising strategy to reduce chemoresistance and relapse risks in ovarian cancer (OC) patients. However, the lack of targetable markers impedes research progress. Here, we demonstrate that CXC motif chemokine receptor …

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Dual-Functional Biomimetic Nanoprobes for PET Imaging-Guided Sonodynamic Therapy and Chemotherapy of Triple-Negative Breast Cancer

Wenzhu Hu, Xingyi Wang, Feng Yuan, Yan Wang et autres

Triple-negative breast cancer (TNBC), a highly aggressive subtype characterized by rapid invasion, metastatic propensity, and rising incidence, remains challenging due to the absence of targeted therapies. This study introduces a biomimetic nanoprobe coated with hybrid cell membranes (erythrocyte and tumor cell membranes) …

hk, cn, us, Malawi (code pays fourni par la source)

Peptide-Based PET Imaging Differentiates Netrin-1 Expression in Tumors

Jingwen Wang, Lixia Feng, Xingbo Long, Hao Yang et autres

Neuroaxonal guidance factor-1 (Netrin-1) is a secreted glycoprotein overexpressed in cancer. It promotes tumor growth and metastasis and has demonstrated potential as a biomarker for tumor theranostics. In this study, we developed a novel Ga-68 labeled peptide radiotracer, termed [ 68 Ga]Ga-DKP, …

us, cn (code pays fourni par la source)

Glycyrrhizinate Monoammonium Cysteine-Loaded Lipid Nanoparticles Allow for Improved Acute Liver Injury Therapy

Yunjie Xu, Pinghui Li, Shiran Sun, Yulin Chen et autres

Background: Acute liver injury (ALI) is a prevalent and potentially lethal condition globally, where pharmacotherapy plays a vital role. However, challenges such as rapid drug excretion and insufficient concentration at hepatic lesions often impede the treatment’s effectiveness. Methods: We successfully prepared glycyrrhizinate …

hk, cn (code pays fourni par la source)

EZH2 regulates pancreatic cancer cells through E2F1, GLI1, CDK3, and Mcm4

Hongfeng Li, Hailong Wang, Yunlong Cui, Wenhua Jiang et autres

Pancreatic cancer (PC) is one of the most common malignant tumors in digestive tract. To explore the role of epigenetic factor EZH2 in the malignant proliferation of PC, so as to provide effective medical help in PC. Sixty paraffin sections of PC …

cn (code pays fourni par la source)

Data from A Paradigm of Cancer Immunotherapy Based on 2-[18F]FDG and Anti–PD-L1 mAb Combination to Enhance the Antitumor Effect

Xuejun Wen, Changrong Shi, Xinying Zeng, Liang Zhao et autres

AbstractPurpose: Efforts have been devoted to select eligible candidates for PD-1/PD-L1 immune checkpoint blocker (ICB) immunotherapy. Here, we have a serendipitous finding of positron emission tomography (PET) imaging tracer 2-[18F]FDG as a potential immunomodulator. Therefore, we hypothesize that 2-[18F]FDG could induce PD-L1 …

Data from A Paradigm of Cancer Immunotherapy Based on 2-[18F]FDG and Anti–PD-L1 mAb Combination to Enhance the Antitumor Effect

Xuejun Wen, Changrong Shi, Xinying Zeng, Liang Zhao et autres

AbstractPurpose: Efforts have been devoted to select eligible candidates for PD-1/PD-L1 immune checkpoint blocker (ICB) immunotherapy. Here, we have a serendipitous finding of positron emission tomography (PET) imaging tracer 2-[18F]FDG as a potential immunomodulator. Therefore, we hypothesize that 2-[18F]FDG could induce PD-L1 …

Supplementary Data from A Paradigm of Cancer Immunotherapy Based on 2-[18F]FDG and Anti–PD-L1 mAb Combination to Enhance the Antitumor Effect

Xuejun Wen, Changrong Shi, Xinying Zeng, Liang Zhao et autres

Supplementary Data from A Paradigm of Cancer Immunotherapy Based on 2-[18F]FDG and Anti–PD-L1 mAb Combination to Enhance the Antitumor Effect

Supplementary Data from A Paradigm of Cancer Immunotherapy Based on 2-[18F]FDG and Anti–PD-L1 mAb Combination to Enhance the Antitumor Effect

Xuejun Wen, Changrong Shi, Xinying Zeng, Liang Zhao et autres

Supplementary Data from A Paradigm of Cancer Immunotherapy Based on 2-[18F]FDG and Anti–PD-L1 mAb Combination to Enhance the Antitumor Effect