Wenjie Chen

Ephrin B2 and Ephrin B3 are receptors for a novel putative henipavirus with zoonotic potential

Guimin Dai, Shuang Yao, Wenjie Chen, J B Zhang et autres

Next-generation sequencing has accelerated the discovery of novel putative viruses in wildlife reservoirs, while identifying those with zoonotic potential remains challenging. In this study, we report the identification and characterization of Ailong virus, a novel putative henipavirus from previous bat metagenomes in …

cn (code pays fourni par la source)

GeoAutoModuler: a knowledge–enhanced large language model for heterogeneous geospatial code understanding and knowledge extraction

Jianyuan Liang, Shuyang Hou, Wenjie Chen, Yaxian Qing et autres

In the era of geospatial big data, massive geospatial modeling scripts have accumulated across the Internet and have become essential carriers of modeling knowledge. However, these scripts are often unstructured and heterogeneous in terms of semantics and logic, making their embedded knowledge …

cn (code pays fourni par la source)

Genotypic Diversity and Antimicrobial Resistance Profiles of Multidrug-Resistant Escherichia coli in Porcine Populations from Hubei, China

Xiaoyue Li, Zewen Liu, Ningning Wang, Wenjie Chen et autres

The indiscriminate and excessive use of antimicrobial agents in livestock production constitutes a significant contributor to antimicrobial resistance (AMR), posing substantial threats to global public health. Despite this critical concern, the genetic diversity and antibiotic resistance patterns of Escherichia coli (E. coli) …

cn (code pays fourni par la source)

Impaired glycolysis-derived serine metabolism as a key driver of podocyte injury with senescence

Hongtu Hu, Zijing Zhu, Jijia Hu, Qian Yang et autres

Chronic kidney disease (CKD) is a major health issue, with podocyte injury with senescence playing a central role in glomerulosclerosis. This study investigates the link between glycolysis-derived serine metabolism and podocyte injury with senescence, focusing on the role of phosphoglycerate kinase 1 …

cn (code pays fourni par la source)

Strategies to optimize duration of immunotherapy in advanced NSCLC: Current evidence and future directions

Ruyue Li, Xiujing Yao, Ying Li, Wenjie Chen et autres

Immune checkpoint inhibitors have revolutionized the treatment of advanced non-small cell lung cancer, yet the optimal duration of therapy remains uncertain, raising concerns about cumulative toxicity, economic burden, and potential overtreatment. We analyzed the current evidence comparing fixed-duration regimens (typically capped at …

cn (code pays fourni par la source)

Multifunctional SIS-PEG-AC bio-patch with enhanced adhesion, sustained anti-inflammatory activity, and regenerative properties to promote lung repair

Heng Li, Deguang Wang, Zixun Wang, Wenjie Chen et autres

cn (code pays fourni par la source)

A single oral administration of resveratrol cocrystals enables potent antisepsis therapy via interfering neutrophil extracellular traps formation

Jue-Xian Wei, Muhammad Inam, Hengzong Mo, Jiayu Huang et autres

Sepsis is a life-threatening syndrome characterized by organ dysfunction resulting from host response disorders and is a common complication in patients suffering from clinical trauma, burns, and infections. Resveratrol, a natural polyphenol compound, possesses anti-inflammatory, antiviral, antibacterial, and antifungal properties, as well …

cn (code pays fourni par la source)

OTUD5 enhances activation of multiple cell death pathways and hyperoxia-induced lung injury by stabilizing TRAF4 and activating the p38/JNK pathway

Xia Gu, Tong Fei Zhu, Guihua Hang, Wenjie Chen et autres

OBJECTIVE: This study aims to elucidate the role of OTUD5 in hyperoxia-induced lung injury and to explore its potential as a therapeutic target for mitigating oxidative stress-related lung damage. METHODS: for 24 h. Lung tissues were analyzed using histological techniques (HE, Masson's, …

cn (code pays fourni par la source)

Developing a crisis leadership evaluation system for Chinese nursing staff during major infectious disease emergencies: a modified Delphi study

Changchang Chen, Xutong Zheng, Man Zhang, Luxi Zhang et autres

AIMS: To create a consensus on the nursing crisis leadership evaluation system during major infectious disease emergencies. BACKGROUND: Crisis leadership is critical to prevent and mitigate an infectious disease infectious disease public health emergency during crisis time. However, there has been no …

cn (code pays fourni par la source)

USP22 promotes angiotensin II-induced podocyte injury by deubiquitinating and stabilizing HMGB1

Zhuan Peng, Xiao‐Xiao Huang, Yangbin Pan, Weiwei Li et autres

cn (code pays fourni par la source)

Influence of Oxygen Annealing Treatment at Different Temperatures on Crystallization Quality and Uv Photosensitivity of Ga2o3/Gan Heterojunction

Wenjie Chen, Ruoyun Yang, Yang-Chao Liu, Lin Gu et autres

An event logic graph for geographic environment observation planning in disaster chain monitoring

Yunbo Zhang, Wenjie Chen, Jie Li, Ke Wang et autres

• A observation event logic knowledge (OELK) ontology is innovatively proposed. • A knowledge mining method of abstract OELK is proposed. • An disaster chain observation planning method based on instantiated OELK is proposed. Effective geographic environment observation planning is the key …

cn (code pays fourni par la source)