Xinran Wang

UMamba-Dual: A dual-branch model based on UMamba for cesarean scar disorder segmentation

Jing Zhou, Jian Zhang, Xinran Wang, Y. N. N. Lin et autres

Introduction and HypothesisAccurate segmentation of cesarean scar disorder (CSDi) in ultrasound images is crucial for clinical diagnosis, disease monitoring, and personalized treatment. However, the ambiguous boundaries and complex anatomical structures of CSDi pose significant challenges. To address this, we propose UMamba-Dual, a …

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A T2-weighted MRI grading system for preoperative prediction of visceral pleural invasion in small non-small cell lung cancers

Ning Zhang, Bei Liu, Hui Feng, Xiaolong Gu et autres

Purpose To evaluate the supplemental diagnostic value of T2WI for assessing VPI in NSCLC ≤3 cm with indeterminate CT features (pleural contact/tags). Materials and methods This prospective single-center study enrolled 138 participants with NSCLC ≤3 cm and CT-suspected pleural involvement, of whom …

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Discovery and validation of proliferative exhausted T cells as a favorable prognostic biomarker in esophageal squamous cell carcinoma

Gang Li, Rui Chen, Xinran Wang, Hao Zhang et autres

Esophageal squamous cell carcinoma (ESCC) is an aggressive malignancy with limited therapies and poor prognosis. While exhausted T cell (Tex) heterogeneity under chronic antigen stimulation is recognized, the role of Tex subsets in shaping the tumor microenvironment (TME) and influencing ESCC outcomes …

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Predictive value of label-free surface-enhanced Raman spectroscopy for locally advanced gastric cancer following neoadjuvant chemoimmunotherapy

Xinran Wang, Bowen Shi, Jinling Jiang, Wenfang Wang et autres

Background: Although neoadjuvant chemoimmunotherapy (NACI) is increasingly applied in clinical settings, its therapeutic efficacy and prognostic significance remain unclear. This study sought to establish a surface-enhanced Raman spectroscopy (SERS)-based approach for assessing treatment efficacy and predicting prognosis in patients with locally advanced …

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Machine Learning-Driven SERS Analysis Platform for Accurate and Rapid Diagnosis of Peritoneal Metastasis from Gastric Cancer

Bowen Shi, Sheng Lu, Luke Zhang, Xinran Wang et autres

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A Priority-Based CSMA/CA Protocol and Performance Analysis for AAV-Assisted WSNs

Min Li, Xinran Wang, Heng Wang

In unmanned aerial vehicle assisted wireless sensor networks (UAV-assisted WSNs), due to the mobility of UAV and the heterogeneity of ground nodes’ locations, the communication windows in which the ground nodes can communicate with UAV varies greatly. Unlike the existing carrier sense …

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Synthesis and Structural Insights into Homoleptic and Heteroleptic Cationic Germylene Gold(I) Complexes

Lifang Wu, Rong Zhang, Xinran Wang, Wen Hua Zeng et autres

Novel homoleptic and heteroleptic cationic germylene-gold(I) complexes were synthesized through the insertion of dialkyl- and acyclic diamino- germylenes into Au-Cl bonds. Structural characterization and DFT calculations revealed the distinct π-back donation and dihedral angles, providing quantitative insights into the stability of germylene …

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Artificial intelligence enhances whole‐slide interpretation of PD‐L1 CPS in triple‐negative breast cancer: A multi‐institutional ring study

Jinze Li, Pei Yu Dong, Xinran Wang, Jun Zhang et autres

BACKGROUND AND AIMS: Evaluation of the programmed cell death ligand-1 (PD-L1) combined positive score (CPS) is vital to predict the efficacy of the immunotherapy in triple-negative breast cancer (TNBC), but pathologists show substantial variability in the consistency and accuracy of the interpretation. …

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Abstract PO5-07-02: AI-assisted interpretation of PD-L1 CPS improves the precision medicine in Triple-negative breast cancer

Jinze Li, Xinran Wang, Yueping Liu

Abstract Objective: The IMpassion 031 and KEYNOTE-355 clinical trial demonstrated the advantages of atezolizumab and pembrolizumab in the treatment of Triple-negative breast cancer (TNBC). However, the application of CPS in assessing PD-L1 expression is challenging. Pathologists have great variability in interpretation of …

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Concordance of assessments of four PD-L1 immunohistochemical assays in esophageal squamous cell carcinoma (ESCC)

Xinran Wang, Jiankun He, Jinze Li, Chun Wu et autres

OBJECTIVE: Given real-world limitations in programmed death-ligand 1 (PD-L1) testing, concordance studies between PD-L1 assays are needed. We undertook comparisons of PD-L1 assays (DAKO22C3, Ventana SP263, Ventana SP142, E1L3N) among observers in esophageal squamous cell carcinoma (ESCC) to provide information on the …

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The new idea of cancer immunotherapy: the expression of PD-L1 may reveal the immunological mechanism of resistance of EGFR-TKIs

Ying Jia, Shi Li, Xinran Wang, Junying Liu et autres

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Effect of storage time of paraffin sections on the expression of PD-L1 (SP142) in invasive breast cancer

Jiankun He, Xinran Wang, Lijing Cai, Zhanli Jia et autres

BACKGROUND: PD-L1 staining using long-stored paraffin sections may not be consistent with the true PD-L1 expression of patients. Therefore, it is necessary to explore the expression of PD-L1(SP142) in paraffin sections of invasive breast cancer with different storage times and the optimal …

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