Feng Li

microRNA-204 as a crucial cancer stem cell related miRNA inhibits stemness of gastric cancer by targeting CD44 and EPCAM

D Li, Ruizhi Zhou, Zhenguo Cheng, Hongde Xu et autres

BACKGROUND: Cancer stem cells (CSCs) and normal stem cells share key properties such as self-renewal and differentiation capacity, yet the microRNAs (miRNAs) that are differentially expressed between them remain poorly characterized. This study aimed to identify such miRNAs, with a focus on …

cn, kr (code pays fourni par la source)

Gene Cluster Directs Diversified Carbazole Biosynthesis via Cooperative Halogenation, Hydroxylation, and Methylation

Qiaoling Wu, Feng Li, Ming Peng, Yingying Chen et autres

Chlocarbazomycins are bioactive carbazoles with therapeutic potential. Here, we report a conserved gene cluster ( ccz ) that directs its biosynthesis via a novel pathway. This cluster encodes a versatile tailoring system, including a regioselective halogenase (CczH), dedicated hydroxylases (CczA/J/D), and a …

cn, th (code pays fourni par la source)

Methyl-CpG-binding domain 2 mitigates osteoarthritis through Steap3 promoter methylation and chondrocyte ferroptosis regulation

Renpeng Peng, Meng Zheng, Honglei Kang, Yimin Dong et autres

Abstract Extensive research has underscored the pivotal role of DNA methylation in the development of various diseases, including osteoarthritis (OA). DNA methylation is regulated by methylation writers, readers, and erasers. As a crucial methylation reader, methyl-CpG-binding domain2 (MBD2) has been implicated in …

cn, qa (code pays fourni par la source)

AMPK upregulates SOCS1 to promote TFEB nuclear transfer, enhances autophagy, inhibits macrophage M1 polarization and relieves acute lung injury

Wensha Nie, Chuxiong Gong, Yongze Liu, Jiawu Yang et autres

cn (code pays fourni par la source)

[Efficacy comparison of subsequent treatment modalities for locally advanced hypopharyngeal cancer with partial response to neoadjuvant chemotherapy].

Rui Wang, Zheng Li, Jun Fang, Junfang Xian et autres

The optimal subsequent treatment for PR-HPSCC may be surgery-based comprehensive treatment, particularly for patients with a GTVRR of 30%-70%. This study offers valuable insights for the stratified treatment of HPSCC, which could contribute to improving overall patient prognosis.

cn (code pays fourni par la source)

Deficiency of vitamin D-binding protein exacerbates liver fibrosis by disrupting iron homeostasis via the activation of YAP signaling

Qing Zheng, Qingquan Tan, Dan Wang, Yanling Ma et autres

cn (code pays fourni par la source)

USP10-stabilized IGF2BP3 promotes tumor growth via m6A-modified SKP2 mRNA in non-small-cell lung cancer

Cong Wang, Xuyang Hou, Qing Guan, Huiling Zhou et autres

cn (code pays fourni par la source)

Selenized neural stem cell-derived exosomes: A neotype therapeutic agent for traumatic injuries of the central nervous system

Wenjing Wang, Guihong Lu, Peilin Guo, Haochong Zhang et autres

Oxidative damage and neuroinflammation are the key features of central nervous system (CNS) injury. Inspired by the neuroprotective properties of neural stem cell-derived exosomes (NExo) and the reactive oxygen species (ROS) scavenging ability of selenium, we develop an advanced NExo bearing ultrasmall …

cn (code pays fourni par la source)

Targeted urinary metabolomics combined with machine learning to identify biomarkers related to central carbon metabolism for IBD

Guan-Wei Bi, Xiaolin Yin, Yue Wang, Xinrui Guo et autres

Introduction: Inflammatory bowel disease (IBD), comprising Crohn's disease (CD) and ulcerative colitis (UC), is a chronic and relapsing inflammatory disorder of the gastrointestinal tract. Current diagnostic approaches are invasive, costly, and time-consuming, underscoring the need for non-invasive, accurate diagnostic methods. Methods: We …

cn (code pays fourni par la source)

Single-cell analysis of ecto-mesenchymal cells derived from the neural crest reveals the regulatory role of P75NTR in odontogenic and osteogenic differentiation

Feng Li, Yanyan Zhang, Keyu Wang, Xin Nie

BACKGROUND: The aim to this study was to explore the effect of p75NTR on the mineralization and development of maxillofacial processes. Moreover, we tried to elaborate the potential mechanism of p75NTR's effect on the odontogenic or osteogenic differentiation ability of neural crest …

cn (code pays fourni par la source)

Posttranscriptional activity of eIF4E contributes to HoxA9-driven leukemogenesis

Fang Zhou, Biljana Culjkovic‐Kraljacic, Christian Bach, Feng Li et autres

us, cn, ca, jp (code pays fourni par la source)

Tanshinone IIA attenuates hepatic stellate cell activation, oxidative stress, and liver fibrosis by inhibiting YAP signaling

Dan Wang, Qingquan Tan, Qing Zheng, Yanling Ma et autres

Tanshinone IIA is derived from Salvia miltiorrhiza and has multiple therapeutic targets and functions. The exact therapeutic effects on liver fibrosis as well as the underlying hepatoprotective mechanisms are still lacking. A liver fibrosis model was established via ligation of the common …

cn (code pays fourni par la source)