Ji-Young Lee

Fight, Flight, Fawn, Freeze: Rethinking Substance Use Through a Stress Response Lens

Angel B. Algarin, Ji-Young Lee, Xiangming Zhan

Purpose of Review: This paper proposes a stress-response framework for understanding substance use in the context of adversity, integrating fight (resistance), flight (adaptive coping), freeze (maladaptive coping), and fawn (strategic assimilation/appeasement) responses, with resilience as a moderating factor. Recent Findings: Evidence indicates …

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Steroid hormone regulation of immunometabolism and inflammation

Ley Cody Smith, Mohankumar Ramar, Greta Riley, Clinton B. Mathias et autres

The metabolism of immune cells adapts to support the energy demands for their activation, differentiation, and effector functions through a process known as metabolic reprogramming. This metabolic plasticity is influenced by both extrinsic and intrinsic factors, including steroid hormones such as glucocorticoids, …

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Adipocyte-Specific Deletion of Histon Deacetylase 9 Reduces Adiposity but Triggers Glucose Intolerance, Hyperglycemia, and Hyperlipidemia in Male Obese Mice

Jae-Eun Lee, Hayoung Woo, Young‐Ki Park, Ji-Young Lee

Objectives: Histone deacetylase 9 (Hdac9) is known to regulate adipocyte differentiation and systemic energy homeostasis. We examined the local and systemic role of adipocyte HDAC9 in weight gain, glucose tolerance, and metabolic and inflammatory responses to an obesogenic diet.

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Baicalin Modulates Inflammatory Response of Macrophages Activated by LPS via Calcium-CHOP Pathway

Hyo‐Jin An, Ji-Young Lee, Wan‐Su Park

Studies on natural products that can alleviate the inflammatory response of macrophages caused by endotoxin (lipopolysaccharide) continue. This study investigated the anti-inflammatory activity of baicalin related to macrophage activation caused by lipopolysaccharide (LPS). Baicalin is a flavone glycoside found in plants such …

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Neuroinflammation in Post-Traumatic Stress Disorder

Dong-Hun Lee, Ji-Young Lee, Dong-Yong Hong, Eun-Chae Lee et autres

Post-traumatic stress disorder (PTSD) is a well-known mental illness, which is caused by various stressors, including memories of past physical assaults and psychological pressure. It is diagnosed as a mental and behavioral disorder, but increasing evidence is linking it to the immune …

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Rubi Fructus Water Extract Alleviates LPS-Stimulated Macrophage Activation via an ER Stress-Induced Calcium/CHOP Signaling Pathway

Do-Hoon Kim, Ji-Young Lee, Young‐Jin Kim, Hyun-Ju Kim et autres

Despite the availability of antibiotics and vaccines, many intractable infectious diseases still threaten human health across the globe. Uncontrolled infections can lead to systemic inflammatory response syndrome and the excessive production of inflammatory cytokines, known as a cytokine storm. As cytokines also …

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Diospyrin Modulates Inflammation in Poly I:C-Induced Macrophages via ER Stress-Induced Calcium-CHOP Pathway

Hyun‐Ju Kim, Inamullah Khan, Adnan Shahidullah, Syed Muhammad Ashhad Halimi et autres

Diospyrin, plant-derived bisnaphthoquinonoid, is known to have anticancer activity. However, pharmacological activity of diospyrin on viral infection is not well known. We investigated effects of diospyrin on macrophages induced by polyinosinic-polycytidylic acid (poly I:C), a mimic of double-stranded viral RNA. Various cytokines, …

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Anti-Inflammatory Effects of Diospyrin on Lipopolysaccharide-Induced Inflammation Using RAW 264.7 Mouse Macrophages

Adnan Shahidullah, Ji-Young Lee, Young‐Jin Kim, Syed Muhammad Ashhad Halimi et autres

Diospyrin is a bisnaphthoquinonoid medicinal compound derived from Diospyros lotus, with known anti-cancer, anti-tubercular, and anti-leishmanial activities against Leishmania donovani. However, the effects of diospyrin on lipopolysaccharide (LPS)-induced macrophage activation and inflammation are not fully reported. In this study, the anti-inflammatory effects …

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Dynamics of AMPA Receptors from Simulations and Electron Microscopy

James Krieger, Béatriz Herguedas, Bishal Kumar Singh, Ji-Young Lee et autres

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A review of pragmatic language interventions for children and adolescents with autism spectrum disorder

Ji-Young Lee, Ji-Hoon Kim

A generalized regime-switching integer-valued GARCH(1, 1) model and its volatility forecasting

Ji-Young Lee, Eunju Hwang

We combine the integer-valued GARCH(1, 1) model with a generalized regime-switching model to propose a dynamic count time series model.Our model adopts Markov-chains with time-varying dependent transition probabilities to model dynamic count time series called the generalized regime-switching integer-valued GARCH(1, 1) (GRS-INGARCH(1, …

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Tolerance for Opposing Views Measure

Ji-Young Lee, Yun‐Jung Choi