Young‐Jin Kim

Differential contributions of cardiovascular health-related lifestyle factors to epigenetic ageing: implications for healthy longevity

Da-eun Lee, Yi Seul Park, Hye-Mi Jang, Bong-Jo Kim et autres

BACKGROUND: Lifestyle and cardiovascular health (CVH) are key determinants of the biological ageing process, which is closely linked to healthy ageing and longevity. Multiple CVH factors may interact and exert combined effects on the biological ageing process; however, studies exploring their collective …

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Structure of Bacillus subtilis Ku-mediated DNA synaptic complex

Jieun Kim, Minjae Jo, Young‐Jin Kim, Min‐Sung Kim

DNA double-strand breaks (DSBs) pose a severe threat to genomic integrity, and cells rely on two major pathways for repair: homologous recombination and non-homologous end joining (NHEJ). While eukaryotic NHEJ requires a multi-component assembly including the Ku70/80 heterodimer, bacterial NHEJ operates with …

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Cryo-EM structures of human OAT1 reveal drug binding and inhibition mechanisms

Kelly H. Kim, Young‐Jin Kim

The organic anion transporter 1 (OAT1) plays a key role in excreting waste from organic drug metabolism and contributes significantly to drug-drug interactions and drug disposition. However, the structural basis of specific substrate and inhibitor transport by human OAT1 (hOAT1) has remained …

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Domoic acid: Toxicity, Analytical Methods, and Safety Management

Kyoungah Lee, Young‐Jin Kim, K.C. Lee, Namhyun Kim et autres

ECM Architecture-Mediated Regulation of β-Cell Differentiation from hESCs via Hippo-Independent YAP Activation

Eunji Shin, Tae Yoon Kwon, Youngbin Cho, Young‐Jin Kim et autres

Changes in the extracellular matrix (ECM) influence stem cell fate. When hESCs were differentiated on a thin layer of Matrigel coated onto PDMS (Matrigel_ PDMS ), they exhibited a substantial increase in focal adhesion and focal adhesion-associated proteins compared with those cultured …

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SARS‐CoV ‐2 spike trimer vaccine expressed in Nicotiana benthamiana adjuvanted with Alum elicits protective immune responses in mice

Shi‐Jian Song, Heeyeon Kim, Eun Young Jang, Hyung-Min Jeon et autres

Summary The ongoing coronavirus disease 2019 (COVID‐19) pandemic has spurred rapid development of vaccines as part of the public health response. However, the general strategy used to construct recombinant trimeric severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) spike (S) proteins in mammalian …

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Development of a Beta Cell-Specific Expression Control Element for Recombinant Adeno-Associated Virus

Sunghee Chai, Young‐Jin Kim, Feorillo Galivo, Craig Dorrell et autres

Diabetes mellitus, caused by loss or dysfunction of the insulin-producing beta cells of the pancreas, is a promising target for recombinant adeno-associated virus (rAAV)-mediated gene therapy. To target potential therapeutic payloads specifically to beta cells, a cell type-specific expression control element is …

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The flip-flop configuration of the PABP-dimer leads to switching of the translation function

Sohyun Gu, Hyung-Min Jeon, Seung Woo Nam, Ka Young Hong et autres

Poly(A)-binding protein (PABP) is a translation initiation factor that interacts with the poly(A) tail of mRNAs. PABP bound to poly(A) stimulates translation by interacting with the eukaryotic initiation factor 4G (eIF4G), which brings the 3' end of an mRNA close to its …

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Plant‐based, adjuvant‐free, potent multivalent vaccines for avian influenza virus via Lactococcus surface display

Shi‐Jian Song, Gyeong‐Im Shin, Jin-Yong Noh, Jiho Lee et autres

Abstract Influenza epidemics frequently and unpredictably break out all over the world, and seriously affect the breeding industry and human activity. Inactivated and live attenuated viruses have been used as protective vaccines but exhibit high risks for biosafety. Subunit vaccines enjoy high …

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Evaluation of cytotoxicity, genotoxicity, and zebrafish embryo toxicity of mixtures containing Hyssopus officinalis, Morus alba, Engraulis japonicus, and 27 other extracts for cosmetic safety assessment

Yuna Ha, Young‐Jin Kim, Youngjin Kim, Jeongyeon Choi et autres

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Rubi Fructus Water Extract Alleviates LPS-Stimulated Macrophage Activation via an ER Stress-Induced Calcium/CHOP Signaling Pathway

Do-Hoon Kim, Ji-Young Lee, Young‐Jin Kim, Hyun-Ju Kim et autres

Despite the availability of antibiotics and vaccines, many intractable infectious diseases still threaten human health across the globe. Uncontrolled infections can lead to systemic inflammatory response syndrome and the excessive production of inflammatory cytokines, known as a cytokine storm. As cytokines also …

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Structural Basis for Activation of the Heterodimeric GABAB Receptor

Yoojoong Kim, Eun-Young Jeong, J. Jeong, Young‐Jin Kim et autres

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