Zhimin Li

Radiotherapy for large ruptured hemorrhagic axillary lymph node metastasis from anaplastic lymphoma kinase-positive lung adenocarcinoma: A case report and review of literature

Zhimin Li, Yang-Chenxi Wang, Kai-Yue Wang, Ning-Jing Xie et autres

BACKGROUND: ) gene fusion is a molecular subtype of non-small cell lung cancer, representing 4%-6% of lung adenocarcinomas. Axillary lymph node (ALN) metastasis from lung cancer is rare, and massive bleeding from such lesions is an even more unusual and life-threatening complication. …

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Optimization of gabapentin dosage in pediatric patients with renal impairment: a physiologically based pharmacokinetic modeling approach

Xiaoli Qin, Chaozhuang Shen, Zhimin Li, Yujie Yang

Background Gabapentin (GAB) is an adjunctive antiepileptic drug widely used in pediatric patients. However, little is known about its pharmacokinetics in pediatric patients under 3 years old or with renal impairment (RI). To address this, we developed a physiologically based pharmacokinetic (PBPK) …

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Pathological significance and therapeutic prospects of HCCS expression patterns in lung adenocarcinoma

Pengfei Luo, Sixuan Wu, Zhimin Li, Shuangfeng Tan et autres

This study examines Holocytochrome c synthase (HCCS) expression in lung adenocarcinoma (LUAD) and its impact on the tumor immune environment. By analyzing multiple tumor databases, the research highlights HCCS expression patterns across various cancer types, focusing on its correlation with M2-type macrophages, …

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Impact of tertiary lymphoid structure-associated biomarkers on pancreatic cancer via a dual-disease analysis of psoriasis and pancreatic cancer

Hao Yu, Quan Bo Yuan, Liuxing Feng, Jiahuan Xu et autres

Pancreatic cancer (PC), often referred to as the "king of cancers", has demonstrated limited success with immunotherapies, many of which are still under development. Psoriasis, a common hereditary skin disorder involving genetic, immune, and environmental factors, is only partially understood and has …

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Prognostic significance of IL11RA and its methylation in lung adenocarcinoma

Zhimin Li, Guicheng He, Hui Zeng, Zhen Wang et autres

Background: in LUAD. Methods: in LUAD. Immune infiltration was evaluated by Gene set enrichment analysis (GSEA) analysis, single-sample gene set enrichment analysis (ssGSEA) analysis and Tumor Immune Estimation Resource (TIMER) database. Results: was closely linked to diverse immune cells, especially B cells. …

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A novel mitochondrial quality regulation gene signature for anticipating prognosis, TME, and therapeutic response in LUAD by multi-omics analysis and experimental verification

Lijun Zeng, Sixuan Wu, Zhimin Li, Yuanbin Tang et autres

BACKGROUND: Lung adenocarcinoma (LUAD) is the predominant form of non-small cell lung cancer (NSCLC). Mitochondrial quality-related genes (MQRGs) contribute to the genesis and advancement of tumors. Despite advances in LUAD treatment and detection, early diagnostic biomarkers are still lacking, and the roles …

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Magnetically driven nanomotors for the selective extraction and highly sensitive SERS analysis of cationic dyes

Zhi-Qin Geng, Gang Wang, Bohan Gu, Bo Wen et autres

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Unveiling the key mechanisms of FOLR2+ macrophage-mediated antitumor immunity in breast cancer using integrated single-cell RNA sequencing and bulk RNA sequencing

Sixuan Wu, Baohong Jiang, Zhimin Li, Yuanbin Tang et autres

Breast cancer (BRCA) is a common malignant tumor, and its immune microenvironment plays a crucial role in disease progression. In this research, we utilized single-cell RNA sequencing and bulk RNA sequencing technologies, combined with in vivo and in vitro experiments, to thoroughly …

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Editorial: Artificial intelligence and imaging for oncology

Yuxiang Zhou, Zhimin Li, Poonam Yadav

Recent advancements in artificial intelligence (AI) and imaging technologies have significantly transformed the diagnostic and therapeutic landscapes of oncology [1,2,3]. Cutting-edge imaging modalities, such as CT, PET, US, and MRI, are being increasingly utilized for tumor imaging [4][5][6][7], with emerging interdisciplinary fields …

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Elevated POSTN expression predicts poor prognosis and is associated with radioresistance in cervical cancer patients treated with radical radiotherapy

Cuiqin Huang, Wentao Xiao, Xiuzhong Yao, Zhimin Li et autres

Cervical cancer (CC) is a significant global health issue and remains one of the leading causes of cancer-related mortality in women. Radiotherapy is a crucial treatment modality for CC; however, tumor heterogeneity and resistance to radiotherapy often result in suboptimal outcomes for …

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Mxene Quantum Dots-Engineered Niox Nanoparticles for High-Efficiency Wide-Bandgap Perovskite Solar Cells

Zihao Wang, Weidong Zhu, Laijun Liang, Dandan Chen et autres

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Exploring the pathophysiology of restless leg syndrome: focus on white matter structure and function

Zairan Wang, Zhimin Li, Jingjing Wang, Jun Gao et autres

BACKGROUND: Restless legs syndrome (RLS) is a sleep disorder characterized by an irresistible urge to move the legs, with pathogenesis involving genetic, environmental, and neurobiological factors. Recent advancements in imaging techniques have provided valuable insights into the pathophysiological mechanisms of RLS. OBJECTIVE: …

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