Impact of tertiary lymphoid structure-associated biomarkers on pancreatic cancer via a dual-disease analysis of psoriasis and pancreatic cancer
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Le résumé fourni par la source
Pancreatic cancer (PC), often referred to as the "king of cancers", has demonstrated limited success with immunotherapies, many of which are still under development. Psoriasis, a common hereditary skin disorder involving genetic, immune, and environmental factors, is only partially understood and has been linked to an elevated risk of various cancers, including PC. However, the precise mechanisms through which psoriasis may influence PC progression remain unclear. A comparative analysis of the immune microenvironments in both diseases revealed that tertiary lymphoid structures (TLS) are downregulated in both conditions. Gene expression profiles from public databases were analyzed, and TLS-associated genes were subjected to Cox regression and Kaplan-Meier analyses. Machine learning algorithms identified GBP2 as a risk factor and ZNF814 as a protective factor. The TLS pathway was underexpressed in PC, and GBP2, PARP9, ESRP1, FERMT1, and ZNF814 were identified as critical determinants of survival outcomes. GBP2 was linked to poor prognosis, while ZNF814 was associated with favorable outcomes. Clinical risk plots, ROC curves, and Kaplan-Meier analyses were used to assess model performance. Additionally, qPCR experiments validated the expression of these genes in pancreatic cancer cell lines. These results offer valuable insights into PC progression, providing a foundation for improved clinical management and future research.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Impact of tertiary lymphoid structure-associated biomarkers on pancreatic cancer via a dual-disease analysis of psoriasis and pancreatic cancer
- Date Crossref
- 01/07/2025
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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First Affiliated Hospital of Xiamen University pays non établi dans la noticeÉtablissement de santé
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Harbin Medical University pays non établi dans la noticeUniversité ou école supérieure
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Third Affiliated Hospital of Harbin Medical University pays non établi dans la noticeÉtablissement de santé
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Putian University Department of Basic Medical Sciences pays non établi dans la noticeUniversité ou école supérieure
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Fujian Medical University pays non établi dans la noticeUniversité ou école supérieure
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School of Medicine Department of Hepato-Biliary-Pancreatic and Vascular Surgery pays non établi dans la noticeUniversité ou école supérieure
First Affiliated Hospital of Xiamen University, Harbin Medical University et Third Affiliated Hospital of Harbin Medical University, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.