Yu Wang

Nanobody-boosted human ASIC1a endocytosis alleviates chronic pain and anxiety-like behaviours

Kun Luo, Xing-Lei Song, Ming-Hui Gao, Qi Wang et autres

Chronic pain is frequently accompanied by affective disturbances, yet existing analgesics provide limited efficacy and raise substantial safety concerns. The proton-gated ion channel ASIC1a contributes to nociceptive sensitisation and affective pain processing, but the lack of tools that selectively target human ASIC1a …

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A systematic review and meta-analysis of acupuncture for intestinal protection and underlying mechanisms in animal models of ulcerative colitis

Jie Zhang, Xihui Zheng, Guang Zuo, Yu Wang et autres

BACKGROUND: Although acupuncture has exhibited potential in the therapy of ulcerative colitis (UC), its particular protective mechanisms remain controversial, and meta-analyses examining these mechanisms are lacking. Accordingly, this investigation endeavors to systematically appraise the intestinal protective effectiveness of acupuncture using animal models …

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Tertiary Lymphoid Structures and CXCL13 as Targets in Intracranial Aneurysm

Zhiyao Zheng, Zishuo Lu, Ziliang Han, Qiheng He et autres

BACKGROUND: Intracranial aneurysms (IAs) are localized dilations of cerebral arteries that pose a significant threat of rupture, leading to fatal subarachnoid hemorrhage. The inflammation driven by immune cell infiltration is believed to be a key driver for the pathogenesis of IAs; however, …

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Ferroptosis-resistant myeloid niche shapes tumor natural evolution in glioblastoma

Yijun Dong, Tingyu Liang, Junlin Li, Lingxiang Wu et autres

Glioblastoma (GBM) exhibits marked spatial and cellular heterogeneity, driving aggressive progression and therapy resistance. Utilizing multifocal GBM as a unique model of tumor evolution, we integrated multi-omics including scRNA-seq, scATAC-seq, and spatial transcriptomics (ST). This revealed a subcluster of bone marrow-derived macrophages …

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Intracranial-Implanted Coupled Electrode Tumor Treating Fields (ICE-TTF) Enable Efficient and Directionally Tunable Electric-Field Therapy for Glioma

Chunhua Hu, Xin Yang, Xiaoman Kang, Tingyu Liang et autres

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Stereotactic Radiosurgery in Multidisciplinary Management of HER2-Positive Gastroesophageal Junction Adenocarcinoma with Large-Brain Metastases: A 9-Year Survival Case

Lan Yu, Yu Wang, L.-Z. Liu, Hongmei Zhang et autres

Patients with advanced gastroesophageal junction (GEJ) adenocarcinoma typically exhibit poor clinical outcomes, especially with brain metastases (BMs). Here, we present a notable patient with HER-2 positive advanced gastric cancer complicated with large-volume BMs who achieved long-term survival reaching 9 years through multidisciplinary …

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Comparing various frailty instruments for predicting adverse outcomes in older patients hospitalized with lower respiratory tract infections

Bingxuan Weng, Jin Jin, Lixue Huang, Yu Wang et autres

OBJECTIVE: Frailty is increasingly recognized in older adults with lower respiratory tract infections (LRTIs), yet the optimal assessment tool and its prognostic value remain unclear. This study evaluates the prevalence, inter-tool agreement, and predictive performance of four frailty measures in this population. …

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ICAM1-Mediated Endothelial Cells and Macrophage Interactions in Modulating GBM Malignant Transformation

Junlin Li, Tingyu Liang, Bo Liang, Xiaoman Kang et autres

Background: Glioblastoma (GBM) recurs frequently as the most common primary malignant brain tumor. Microvascular proliferation is a hallmark of GBM. Endothelial cells contribute to the tumor microenvironment (TME) in primary GBM and promote malignancy. However, their role in recurrent GBM (rGBM) remains …

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Noninvasive prediction of lymphovascular invasion in rectal cancer without lymph node metastasis using a SHAP-interpretable combined model integrating MRI radiomics features and clinical immune-inflammatory biomarkers: a bicenter study

Leping Peng, Jingjing Niu, Gang Huang, Fan Zhang et autres

BACKGROUND: Lymphovascular invasion (LVI) status in rectal cancer (RC) without lymph node metastasis (LNM) can significantly influence the patient's treatment decisions. This study aims to develop and validate a combined model based on MRI radiomics features integrated with clinical immune-inflammatory biomarkers for …

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Role of Multiparametric Ultrasound in Predicting the IDH Mutation in Gliomas: Insights from Intraoperative B-Mode, SWE, and SMI Modalities

Siman Cai, Hao Xing, Yuekun Wang, Yu Wang et autres

Objectives: To investigate the correlation between intraoperative conventional ultrasound, SWE, and SMI ultrasound manifestations of glioma and the expression of immunohistochemical markers. Methods: Patients with single superficial supratentorial glioma scheduled for brain tumor resection in our neurosurgery department from October 2020 to …

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Alignment-free unique molecular identifier clustering suppresses sequencing errors for accurate detection of low-frequency DNA variants

Fei Yu, Dongyang Song, Yu Wang, Mingze Bai et autres

Accurate detection of low-frequency DNA variants (below 1%) is essential in diverse biological and clinical contexts, yet remains fundamentally constrained by the high intrinsic error rates of next-generation sequencing technologies. Although unique molecular identifiers (UMIs) have significantly mitigated these errors by uniquely …

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Mechanism of Actinidia chinensis Planch in the treatment of oesophageal cancer based on network pharmacology and experimental validation

Yu Wang, Jianxin Guo, Ming Sheng Huang, Shuang Gao et autres

Bioinformatics databases were utilised to screen targets of Actinidia chinensis Planch and oesophageal cancer. Gene Ontology (GO) and Kyoto Encyclopaedia of Genes and Genomes (KEGG) enrichment analyses were performed for both cross-targets. The core targets were obtained by protein-protein interaction analysis (PPI), …

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