Tertiary Lymphoid Structures and CXCL13 as Targets in Intracranial Aneurysm
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Le résumé fourni par la source
BACKGROUND: Intracranial aneurysms (IAs) are localized dilations of cerebral arteries that pose a significant threat of rupture, leading to fatal subarachnoid hemorrhage. The inflammation driven by immune cell infiltration is believed to be a key driver for the pathogenesis of IAs; however, the detailed immune cell landscape and spatial composition of immune cells remain unclear. METHODS: In this study, we employed an integrated multi-omics approach using human IA tissues, including single‑cell RNA sequencing, spatial transcriptomics, microarray data, and multiplex immunofluorescence, to construct a comprehensive immune cell atlas of IAs, providing a systematic characterization of their immune composition and spatial architecture. Findings were further validated in a mouse model of IA. RESULTS: We identified, for the first time, tertiary lymphoid structures within the aneurysm wall and demonstrated that their presence strongly correlates with rupture. Furthermore, we observed a significant expansion of a specific T-cell subset, C-X-C motif chemokine legand 13 (CXCL13)-positive T-follicular helper cells. These cells were critical for B-cell recruitment and the structural organization of the tertiary lymphoid structures. In the IA mouse model, CXCL13 neutralization effectively suppressed both aneurysm formation and rupture. CONCLUSIONS: T follicular helper cells as central elements in IA progression and highlight the CXCL13 signaling axis as a promising therapeutic target for preventing aneurysm advancement.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Tertiary Lymphoid Structures and CXCL13 as Targets in Intracranial Aneurysm
- Date Crossref
- 28/08/2026
- Éditeur
- Ovid Technologies (Wolters Kluwer Health)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Chinese Academy of Medical Sciences & Peking Union Medical College pays non établi dans la noticeUniversité ou école supérieure
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Peking Union Medical College Hospital Department of Neurosurgery pays non établi dans la noticeÉtablissement de santé
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National Clinical Research Center for Digestive Diseases pays non établi dans la noticeÉtablissement de santé
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Hi-Z Technology (United States) pays non établi dans la noticeEntreprise
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Capital Medical University National Clinical Research Center for Neurological Diseases pays non établi dans la noticeUniversité ou école supérieure
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King's College London pays non établi dans la noticeUniversité ou école supérieure
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Beijing Tian Tan Hospital pays non établi dans la noticeÉtablissement de santé
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School of Biomedical Engineering and Imaging Science Department of Cancer Imaging pays non établi dans la noticeUniversité ou école supérieure
Chinese Academy of Medical Sciences & Peking Union Medical College, Department of Neurosurgery — Peking Union Medical College Hospital et National Clinical Research Center for Digestive Diseases, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.