Wei Zhang

Research on Carotid Blood Flow Detection Based on Interferometric Diffuse Speckle Contrast Analysis and Its Application in Preventing Ischemic Stroke

Guang Han, Wei Zhang, Qinglong Yang, Ruijuan Chen et autres

This study applied the Interferometric Diffusion Speckle Contrast Analysis (iDSCA) system developed by our research group to detect changes in common carotid artery blood flow. Through animal experiments combining color Doppler ultrasound and human in vivo experiments integrating Transcranial Doppler, the iDSCA …

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Enhanced Integrative Diagnosis and Therapeutic Strategy for Hepatic Ischemia-Reperfusion Injury through HOCl-Sensitive Cysteine Delivery System for Targeted Antioxidant Modulation

Wen Jie Zhang, Yanjiao Li, Xin Wang, Hui Wang et autres

Hepatic ischemia-reperfusion injury (HIRI) is a major cause of postoperative liver insufficiency and liver failure, and its pathological process is closely related to the synergistic dysregulation of oxidative stress. Currently, the diagnosis of HIRI is separated from its treatment, making it difficult …

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Detection of Shiitake powder adulteration using near-infrared spectroscopy combined with chemometrics

Xiaowei Tie, Wei Zhang, Zhenhua Wu, Kunxiu Sun et autres

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Gut microbiota characteristics and its biological function analysis in patients with tuberculosis and diabetes mellitus co-morbidity

Feifan Xu, Jingjing Ren, L Zhang, Juan Ma et autres

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Abstract A068: Preclinical investigation of orally bioavailable, potent pan-KRAS (ON/OFF) inhibitor JAB-23E73

Peng George Wang, Xiaoyu Liu, Wei Zhang, Dan Liu et autres

Abstract Background: Mutant KRAS is commonly found as an oncogenic driver and has remained an undruggable target for decades. Despite the recent success of mutant-specific KRASG12C inhibitors, there are limited therapeutic options for patients carrying other KRAS driver mutations. Development of pan-KRAS …

Analysis of FNDC1 as a diagnostic marker and potential therapeutic target for ovarian serous cancer

Hongying Jiao, Jing Tian, Qiao Liu, Ming Jiang et autres

BACKGROUND: Fibronectin type III domain containing 1 (FNDC1) is a member of fibronectin type III domain protein family, which is known to play an important role in the metastasis of some cancers. However, it has not been reported about the relationship between …

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Multi-omics profiling reveals key microbial and metabolic variations in ischemic stroke: insights into gut and oral microbiota

Lihe Yao, Lei Li, Jun Chen, Yuan Ma et autres

Dysbiosis of oral and gut microbiota may influence ischemic stroke (IS) pathogenesis through immune and metabolic mechanisms. This study investigated microbial translocation between oral and gut niches and its functional metabolic impact in IS patients. A total of 57 individuals were analyzed, …

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The Prognostic Significance of Vesicle‐Mediated Transport‐Related Genes as Risk Markers in Gastric Cancer

Yunjie Wan, Ganshu Xia, Shoumiao Li, Wei Zhang et autres

Vesicle-mediated transport plays a role in intercellular communication in tumor microenvironment, affecting tumor development and prognosis. This study attempted to establish risk markers for gastric cancer (GC) based on vesicle-mediated transport-related genes, providing a new perspective for evaluating immunotherapeutic response and prognosis …

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Author response for "ROS-Responsive SERS Probes for Real-time Monitoring of Oxidative Stress in Traumatic Brain Injury"

Dianqi Zhang, Li Zhou, Wei Zhang, Fabiao Yu et autres

Surface Engineering‐Induced d‐Band Center Down‐Regulation in High‐Entropy Alloy Nanowires for Enhanced Nanozyme Catalysis (Adv. Sci. 25/2025)

Hanting Wang, Song Zhou, Wei Zhang, Yuxin He et autres

High-Entropy Alloy Nanozymes The image features a novel PtRuFeCoNi high-entropy alloy (HEA) nanozymes surface-engineered by polydopamine (PDA) with superior peroxidase-like activity and photothermal properties. Siqiao Li, Zhengwei Zhang, and co-workers reveal self-polymerized PDA coating moderately lowers the d-band center of the HEA, …

Copper‐Doped Prussian Blue Nanozymes: Targeted Starvation Therapy Against Gram‐Positive Bacteria via the ABC Transporter Inhibition

Wei Zhang, Qiang Niu, Yuyu Cui, Kelong Fan et autres

Abstract Nonspecific bactericidal agents often damage host cells and exhibit off‐target toxicity, while existing bacteria‐targeting strategies face challenges in complexity, cost, and compromised efficacy. This study introduces copper‐doped Prussian blue (CuPB) nanozymes that selectively eradicate Gram‐positive bacteria through a novel starvation therapy …

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Deep learning assisted non-invasive lymph node burden evaluation and CDK4/6i administration in luminal breast cancer

Yuhan Liu, Jinlin Ye, Zecheng He, Mingyue Wang et autres

≥ 4) with an AUC of 0.77. LNPN provided a non-invasive method to assess lymph node metastasis and recurrence risk, potentially reducing unnecessary axillary lymph node dissection (ALND), and facilitating decision-making regarding the intervention of CDK4/6i in luminal breast cancer patients.

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