Wenting Li

Jer1–Ga2–LpR1 axis mediates upstream input of alpha-mannosidosis

Wenting Li, Shengnan Li, Qi Wang, Xiuxiu Ti et autres

Alpha-mannosidosis (AMD) is a well-known lysosomal storage disorder caused by the loss of α-mannosidase activity due to the mutation of the MAN2B1 gene. Defective α-mannosidase cannot completely degrade the sugar chains of upstream input glycoproteins, leading to the accumulation of oligosaccharides with …

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Machine learning-driven identification of key chemical determinants of tobacco leaf sensory irritation

Wenting Li, Xuehui Sun, Zhe Jin, Bin Peng et autres

Introduction: To identify the key chemical components affecting the sensory irritation of tobacco leaves, a binary classification model for high and low irritation was constructed based on 78 chemical components and sensory evaluation scores of 353 tobacco leaf samples. Methods: First, the …

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Hydroperoxide-Mediated Photochargeable Molecular Cage for Postirradiation Dark Catalysis

Jiang-Pei Yuan, Zong-Jie Guan, Wenting Li, Ling Yuan et autres

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Ketyl radical-mediated exfoliation and electron storage for solar hydrogen peroxide production

Bing Han, Huarui He, Jiali Liu, Yihui Jia et autres

Efficient photocatalytic production of hydrogen peroxide is a sustainable strategy for green chemical synthesis and environmental remediation. Herein, we report TPM-DADK, a segmented π-conjugation polymer containing redox-active anthrazolines and tetraphenylmethane nodes, enabling visible-light-driven hydrogen peroxide generation through a direct two-electron oxygen reduction …

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Medical Dressing with Semiconducting Polymer Dots for Photocatalytic Hydrogen Evolution and Diabetic Wound Healing

Feixue Mi, Yuan Wang, Ningjing Zhao, Yang Li et autres

Impaired wound healing is the most common and severe complication in diabetic patients. Here, we develop a new type of medical dressing for diabetic wound healing by using photocatalytic hydrogen evolution from semiconducting polymer dots (Pdots) under red-light irradiation. The Pdots consist …

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Baicalin and ginsenoside Rb1 suppress the activation of cardiac fibroblasts via regulating the GRK2/AT1R/MasR network

Honglei Zhang, Jiaxing Xu, Wenting Li, Ziqing Wang et autres

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Highly Efficient Photocatalytic Elimination of Bacteria and Antibiotic Resistance Genes via a Strong Oxidation Surface in Donor‐Acceptor SA‐PDI@C 60

Wenting Li, Wenlu Li, Xiaolin Zhu, Yizhou Yan et autres

Abstract The elimination of antibiotic‐resistant bacteria (ARB) and their antibiotic resistance genes (ARGs) requires photocatalysts with strong oxidative surfaces and efficient charge separation under natural light. Herein, a novel donor‐acceptor (D‐A) supramolecular photocatalyst, SA‐PDI@C 60 , is reported for natural light‐driven antibacterial …

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Hydrogen-bond bridging dually facilitates exciton dissociation and charge migration for enhanced photocatalytic water oxidation

Jianfang Jing, Xinyue Tan, Jingyi Xu, Wenting Li et autres

ABSTRACT As a kinetic bottleneck in artificial photosynthesis, the hole-mediated oxygen evolution reaction (OER) remains constrained by inefficient charge separation. We demonstrate here a hydrogen-bonded perylene diimide/aminated-fullerene (PDINH/C60NH3) supramolecular photocatalyst that concurrently enhances exciton dissociation efficiency (from 39.5% to 70.5%) and charge …

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Impaired mitochondria-initiated crosstalk with lysosomes reciprocally aggravates mitochondrial defect through LManVI

Shengnan Li, Zhaoliang Shan, Guochun Zhao, Yuwei Li et autres

Mitochondria coordinate with lysosomes to maintain cellular homeomstasis. However, in mitochondrial defect condition, how they communicate is less clear. Here, utilizing dMterf4 RNAi fly model, we find that expression of lysosomal alpha-mannosidase VI (LManVI) is significantly downregulated. Mechanistically, we show that dMterf4 …

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Performance analysis and optimization of an ammonia-fueled solid oxide fuel cell-micro gas turbine-rankine cycle system as a power station in an emerging industrial area

Yan Zhu, Liangyu Tao, Wenting Li, Hongchun Zhao et autres

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Near-Infrared Light-Driven Efficient Tumor Elimination via Strong Oxidative Photogenerated Holes in Donor–Acceptor Supramolecular Porphyrin

Wenting Li, Jianfang Jing, Ziyu Wei, Jingyi Xu et autres

High Resolution Image Download MS PowerPoint Slide Efficient photocatalytic tumor therapy relies on deep tissue penetration via near-infrared (NIR) light absorption and potent oxidative stress induced by efficient photogenerated hole (h + ) migration. Herein, we report a supramolecular donor–acceptor (D–A) structure …

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Early intervention of baicalin suppresses obesity-induced adipose tissue fibrotic remodeling through Interfering NF-κB/HIF-1ɑ/GRK2 Signaling Pathway

Ying Zeng, Wenting Li, Tingting Ma, Honglei Zhang et autres

Obesity-induced adipose tissue (AT) fibrosis is difficult to reverse, indicating the importance of early intervention. G protein-coupled receptor kinase 2 (GRK2) is a potential regulator of energy metabolism. Baicalin can improve insulin sensitivity and metabolic homeostasis. However, their impacts on AT fibrosis …

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