Kai Wang

Bone marrow mesenchymal stem cells alleviate liver fibrosis after rat liver transplantation through JAK1/STAT5 pathway

Zhuyuan Si, Shengqiao Zhao, Zhixin Zhang, Tianran Chen et autres

OBJECTIVE: The effectiveness of bone marrow mesenchymal stem cells (BMSCs) in post-transplantation liver fibrosis has not been studied. The aim of this study was to investigate the effect of BMSCs on liver fibrosis and their role in the Janus-activated kinase (JAK) 1/ …

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Investigating the protective mechanism of Astragalus membranaceous (Fisch.) against cerebral ischemia-reperfusion injury in rats: A metabolomics and network pharmacology approach

Ruimin Liang, Yue Chen, Ruizhen Zhang, Kai Wang et autres

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Peripheral nerve-derived CSF1 induces BMP2 expression in macrophages to promote nerve regeneration and wound healing

Kai Wang, Binyu Song, Yuhan Zhu, Tong Wang et autres

The precise mechanisms regulating inflammatory and prorepair macrophages have not been fully elucidated, despite the pivotal role played by innate immunity in wound healing. We first employed a denervation wound model to validate the crosstalk between neurons and macrophages. Compared to normal …

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Immediate SVF-Gel Injection Reduced Incision Scar Formation: A Prospective, Double-Blind, Randomized, Self-control Trial

Xiangke Rong, Jiezhang Tang, Jizhong Yang, Kai Wang et autres

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Machine learning and single‐cell transcriptome profiling reveal regulation of fibroblast activation through THBS2/TGFβ1/P‐Smad 2/3 signalling pathway in hypertrophic scar

Binyu Song, Yuhan Zhu, Ying‐Yong Zhao, Kai Wang et autres

Hypertrophic scar (HS) is a chronic inflammatory skin disorder characterized by excessive deposition of extracellular matrix, and the mechanisms underlying their formation remain poorly understood. We analysed scRNA-seq data from samples of normal skin and HS. Using the hdWGCNA method, key gene …

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Pre-clinical evaluation of thermosensitive decellularized adipose tissue/platelet-rich plasma interpenetrating polymer network hydrogel for wound healing

Jiezhang Tang, Huichen Li, Han Peng, Zhaoxiang Zhang et autres

Wound healing remains a challenge worldwide, and an ideal wound dressing that promotes healing is urgently needed. In this study, we developed a thermosensitive injectable hydrogel known as the thermosensitive decellularized adipose tissue/platelet-rich plasma interpenetrating polymer network (t-DPI) hydrogel based on decellularized …

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Mechanism of Huangqi–Honghua combination regulating the gut microbiota to affect bile acid metabolism towards preventing cerebral ischaemia–reperfusion injury in rats

Kai Wang, Yue Chen, Jinyi Cao, Ruimin Liang et autres

CONTEXT: L. (Asteraceae) is used in traditional Chinese medicine for the treatment of stroke, its underlying mechanism remains unclear. OBJECTIVE: The objective of this study is to elucidate the mechanism underlying Huangqi-Honghua (HQ-HH) for the treatment of ischaemic stroke by gut microbiota …

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Bone marrow mesenchymal stem cells enhance angiogenesis and promote fat retention in fat grafting via polarized macrophages

Juanli Dang, Jizhong Yang, Zhou Yu, Lin Chen et autres

BACKGROUND: Fat grafting is one of the most common soft tissue filling methods in plastic surgery. Bone marrow mesenchymal stem cell (BM-MSC) transplantation is an effective method for improving graft retention. However, the role of BM-MSCs in fat transplantation is not completely …

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Exosomes laden self-healing injectable hydrogel enhances diabetic wound healing via regulating macrophage polarization to accelerate angiogenesis

Kai Wang, Ruonan Dong, Jiezhang Tang, Huichen Li et autres

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Network pharmacology‑based prediction of the active compounds and mechanism of Buyang Huanwu Decoction for ischemic stroke

Kai Wang, Lei Lü, Jinyi Cao, Yi Qiao et autres

Buyang Huanwu Decoction (BYHWD) is used to promote blood circulation and is widely used in Chinese clinical practice for the treatment and prevention of ischemic cerebral vascular diseases. However, the mechanism and active compounds of BYHWD used to treat ischemic stroke are …

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Investigation of the Multi-Target Mechanism of Guanxin-Shutong Capsule in Cerebrovascular Diseases: A Systems Pharmacology and Experimental Assessment

Juanli Zhang, Jiaxin Zhao, Yang Ma, Wenjun Wang et autres

Guanxin-Shutong capsule (GXSTC), a combination of Mongolian medicines and traditional herbs, has been clinically proven to be effective in treating cerebrovascular diseases (CBVDs). However, the underlying pharmacological mechanisms of GXSTC in CBVDs remain largely unknown. In this study, a combination of systems …

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A Network Pharmacology Technique to Investigate the Synergistic Mechanisms of Salvia miltiorrhiza and Radix puerariae in Treatment of Cardio‐Cerebral Vascular Diseases

Yang Ma, Wenjun Wang, Jiani Yang, Sha Zhang et autres

OBJECTIVE: (RP) in the treatment of cardio-cerebral vascular diseases (CCVDs). METHOD: The ingredients and targets of SM and RP were obtained from Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP), and the disease targets were obtained from Therapeutic Target Database …

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