Tianran Chen

Contrasting responses of the eastern and western Chinese Loess Plateau to Heinrich events

Qingying Wang, Guoqiao Xiao, Mingqiang Liang, Zixuan Zhang et autres

cn, be (code pays fourni par la source)

Neutrophil-associated plasma proteomics identifies HDAC1 as a baseline biomarker of immune tolerance during immunosuppressant withdrawal after pediatric liver transplantation: a single-center cohort study

Ruofan Wang, Tianran Chen, Guang Li, Weiping Zheng et autres

Background: In pediatric liver transplantation (pLT), long-term immunosuppression (IS) contributes to infection risk and chronic toxicity, yet IS minimization or withdrawal requires balancing rejection risk. Practical biomarkers for baseline risk stratification at the start of planned withdrawal remain scarce. This study investigated …

cn (code pays fourni par la source)

Beyond “Saving” Life: Biopolitical Dynamics and Virus Narrative in Saving the World

Tianran Chen

Abstract Julia Alvarez’s Saving the World (2006) employs virus narratives to weave two storylines into a shared account of the entanglement of life, medical intervention, and biopolitics. Reading the novel through the biopolitical transformations of the early nineteenth century, this article examines …

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Coral geochemical archives reveal shipbreaking-driven heavy metal pollution in the Bay of Bengal

Md Habibur Rahman, Tianran Chen, Syeda Maksuda Yeasmin, Md Hafijur Rahaman Khan

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Sandwich immunoassay for evaluation of serum Kita-Kyushu Lung Cancer Antigen-1 as a potential diagnostic biomarker for gastric cancer

Tianran Chen, Li Li, Yumeng Wang, Rutian Li

BACKGROUND: Kita-Kyushu Lung Cancer Antigen-1 (KK-LC-1) has been proved to be highly expressed in gastric cancer. Nevertheless, no studies have yet investigated the expression levels of KK-LC-1 in the serum of patients with gastric cancer, its diagnostic potential, or its association with …

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Novel tetrameric bispecific KK-LC-1×CD16A-armed memory-like NK cells enhance antitumor efficacy in gastric cancer

Mengzhu Li, Tianran Chen, Siwen Wu, Yuxiang Li et autres

BACKGROUND: Cytokine-induced memory-like natural killer (CIML NK) cells demonstrate potent antitumor efficacy against hematological malignancies. Nevertheless, the therapeutic potential of adoptive NK cell transfer remains constrained in solid tumors due to insufficient tumor infiltration efficiency. Developing a novel tetravalent bispecific killer engager …

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Mesothelin-directed protein-drug conjugates for mesothelin-low solid tumor therapy

Yanru Wang, Jiayao Yan, Lin Li, Tianran Chen et autres

Mesothelin (MSLN) is an attractive therapeutic target for precision cancer treatments. However, MSLN can be cleaved and shed from tumor cells, resulting in the presence of soluble MSLN (sMSLN), which significantly hinders the efficacy of MSLN-targeted therapies. Here, we identify a MSLN-targeting …

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Early Pleistocene integration of the Yellow River III: Paleontological and paleohydrological evidence from the Fenwei Basin

Guoqiao Xiao, Xinru Lin, Tianran Chen, Qing Pan et autres

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Decadal variability and anthropogenic influence on trace element dynamics in the Bay of Bengal: Evidence from high-resolution coral records

Md Habibur Rahman, Tianran Chen, Syeda Maksuda Yeasmin, Yuyang Lin et autres

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Bone marrow mesenchymal stem cells alleviate liver fibrosis after rat liver transplantation through JAK1/STAT5 pathway

Zhuyuan Si, Shengqiao Zhao, Zhixin Zhang, Tianran Chen et autres

OBJECTIVE: The effectiveness of bone marrow mesenchymal stem cells (BMSCs) in post-transplantation liver fibrosis has not been studied. The aim of this study was to investigate the effect of BMSCs on liver fibrosis and their role in the Janus-activated kinase (JAK) 1/ …

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Bifunctional Phage Particles Augment CD40 Activation and Enhance Lymph Node-Targeted Delivery of Personalized Neoantigen Vaccines

Xiaotong Chen, Lei Lei, Jiayao Yan, Xingzhou Wang et autres

Although personalized neoantigen cancer vaccines have emerged as a promising strategy for cancer treatment, challenges remain to develop immune-stimulatory carriers which allow simultaneous transport of adjuvants and vaccines to lymph nodes (LNs). With inherent immunogenicity, genetic plasticity, and efficiency for large-scale production, …

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Definition, Prognosis, and Complication Analysis of Early Allograft Dysfunction in Pediatric Liver Transplantation: A Retrospective Cohort Study

Zhuyuan Si, Zhixin Zhang, Shengqiao Zhao, Tianran Chen et autres

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