Jie Zhang

Formononetin Alleviates Cigarette Smoke Extract-Induced Lung Injury in Mice with Gut Microbiota and Taurine/SLC6A6/NF-κB Modulation

Zheng Ma, 胡森, Zhongting Lv, Shuang Liu et autres

Cigarette smoke exposure is a major preventable risk factor for respiratory disease and drives oxidative and inflammatory lung injury, highlighting the urgent need for safe, multi-target interventions beyond conventional anti-inflammatory therapy. Formononetin (FMN), a naturally occurring isoflavone with antioxidant, anti-inflammatory, and microbiota-modulating …

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Astragalus polysaccharide alleviates neuropathology and cognitive deficits by modulating gut microbiota and neuroinflammation in an Alzheimer’s disease model

Xiaoli Cui, Zhen Wei, Qingshui Wang, Sizhe Du et autres

Background Emerging evidence indicates that the neuroprotective effects of Astragalus polysaccharides (APS), an extract compound and bioactive constituent derived from traditional Chinese herbs, may be relevant to an effective prescription for delaying progression of Alzheimer’s disease (AD), yet the underlying mechanisms remain …

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Anti-Androgenic Potential of Plant Extracts: Molecular Mechanisms, Synergistic Effects, and Nutritional Interventions

Yijing Yang, Yong Pang, Jie Zhang, Li Ren

Androgen dysregulation impairs the homeostasis of the prostate, hair follicles, and ovaries, driving the pathogenesis of prostate cancer (PCa), benign prostatic hyperplasia (BPH), androgenetic alopecia (AGA), and polycystic ovary syndrome (PCOS). Current antiandrogen therapies are constrained by drug resistance, off-target toxicity, and …

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Single-nucleus transcriptomics reveals cell-type-resolved brain responses to concurrent exposure to polyethylene nanoplastics and butyl benzyl phthalate

Yitong Lu, Houdao Ren, Zhongting Lv, Tiehua Zhang et autres

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Chromosome-level genome assembly and annotation of the black-spot snapper, Lutjanus fulviflamma

Xumin Wang, Siluo Jing, Ying Jin, Jie Zhang et autres

Lutjanus fulviflamma is a commercially significant offshore warm-water fish species predominantly inhabiting shallow marine environments. Previous studies have primarily concentrated on the development of genetic markers and evolutionary relationships. In this study, a chromosome-level reference genome was constructed through the integration of …

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Ginsenoside Rg1 Alleviates Lead-Induced Neurotoxicity Through Nrf2-Associated Modulation of Oxidative Stress and Ferroptosis

Yiyao Gong, Jie Zhang, T Wang, Xiang Li et autres

Chronic exposure to lead (Pb) represents a persistent environmental hazard that can impair hippocampal integrity and cognitive function, while effective protective strategies remain limited. Ginsenoside Rg1 is an important bioactive constituent derived from Panax ginseng and has been reported to possess antioxidant …

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Genistein Protects Against Lead-Induced Cognitive Impairment Through a Glutathione-Dependent Redox–Mitochondrial Apoptosis Axis

Zhongting Lv, Zeyu Ma, Yong Pang, H Y Wang et autres

Lead exposure remains a pervasive environmental and public health threat, imposing a substantial burden of neurodevelopmental and cognitive dysfunction, yet safe mechanism-oriented interventions remain limited. Genistein, a soybean-derived isoflavone with antioxidant and neuroprotective potential, may counter heavy metal-induced neural injury; however, whether …

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Toxicological impacts of neonicotinoid insecticides in zebrafish: A review of individual and mixture toxicity

Shuang Liu, J J Lu, Zhongting Lv, Jie Zhang et autres

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Integration of phytohormones, miRNAs and transcriptome sequencing in cucumber fruit development under high-temperature stress

Dan Zhong, Kanghua Du, Da Zhang, Wei Lv et autres

Continuous heat stress resulted in abnormal cucumber fruit development. Mult-omics analyses of heat-sensitive cucumber line '75-2' across four developmental stages under HT/NT conditions, revealed miRNA-mediated morphogenesis mechanisms. Integrated phenotyping identified IPA, ZT, JA, and GA3 as key regulators of cell proliferation/expansion. We …

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The impact of pedicle screw transitional segment and thread distribution on postoperative rod-screw system failure

Wen Peng, Weichao Wang, Jie Zhang, Yami Liu et autres

Aims: This study aimed to evaluate the differences in postoperative internal fixation system failure between two distinct pedicle screw designs, and to examine how variations in the transitional segment and thread distribution of these screws influence the bending mechanical properties of the …

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A new paradigm for electrical modeling in site leakage diagnostics: A label-scarce three-dimensional simulation surrogate using physics-informed neural networks

Feng Chen, Aixia Zhou, Linhai Ye, Wenchang Li et autres

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Vonoprazan-related adverse events: a pharmacovigilance study based on the FDA adverse event reporting system

Yali Zhong, Chuan Hou, Jie Zhang, Wang Li et autres

This study comprehensively evaluated the safety profile of Vonoprazan using data from the FDA Adverse Event Reporting System (FAERS) from the first quarter (Q1) of 2023 through the first quarter (Q1) of 2025. This analysis was restricted to real-world reports collected after …

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