Lei Wang

Progression and influencing factors of knee osteoarthritis based on a multi-state Markov model: Data from OAI

Aerman Nuer, Yasi Yang, Boran Sun, Yunhan Wang et autres

Background: Knee osteoarthritis (KOA) is a chronic disorder marked by progressive cartilage loss and functional decline. Current classifications miss bidirectional transitions, particularly in early and late stages, hindering early intervention. Methods: Participants aged 45-79 years from the Osteoarthritis Initiative (OAI) were analyzed …

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Associations of neutrophil-based inflammatory markers with all-cause and cardiovascular mortality in individuals with osteoarthritis

Tingting Wu, Yue Xiong, Lei Wang, Erye Zhou et autres

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Comment on: “Prevalence of hypertriglyceridemia and its association with extreme cardiovascular risk in patients with acute and chronic coronary syndrome enrolled in a cardiac rehabilitation program”

Lei Wang, Yuehua Yan, Jun Geng

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Clinical Course, Outcomes, and Risk Factors of Myocarditis and Pericarditis Following Administration of mRNA-1273 Vaccination: A Protocol for a Federated Real-World Evidence Vaccine Safety Study Using Data from Five European Data Sources

Laura C. Zwiers, Diederick E. Grobbee, Rob Schneijdenberg, Corine Baljé et autres

Background: Myocarditis and pericarditis are recognised risks following COVID-19 vaccination, including the mRNA-1273 vaccine. Most cases occur shortly following the second dose of this vaccine, and incidence is highest among young males. However, little is known about risk factors beyond age and …

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Plasma Lyso-PE 22:6 and Lyso-PE 20:4 are associated with development of mild to moderate depression revealed by metabolomics: a pilot study

Jingbo Yu, Haixia He, Xianyang Chen, Yue Han et autres

BACKGROUND: Mild to moderate depression (MMD), as an early stage of depression, has a high incidence and may progress to severe depression, even leading to suicide. The lack of effective screening and treatment is due to the unknown metabolic changes and processes …

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Representativeness of participants in the Danish National Health Survey across 422,371 orthopedic surgeries: a study of hip and knee arthroplasty and hip fracture patients

Simon Storgaard Jensen, Nadia R Gadgaard, Heidi Amalie Rosendahl Jensen, Lei Wang et autres

AIMS: Orthopedic registries have provided valuable knowledge about risk for and prognosis after total hip arthroplasties (THA), knee arthroplasties (KA), and hip fractures. However, registries are often limited by the lack of data on health risk behaviors, quality of life, and social …

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Accelerated aging mediates the association between rheumatoid arthritis and depression severity

Tingting Wu, Lei Wang, Jian Wu, Yufeng Yin et autres

BACKGROUND: This study aimed to investigate the associations among phenotypic age acceleration (PAA), the prevalence of rheumatoid arthritis (RA), and depression severity and to examine the potential mediating role of PAA in the RA-depression relationship. METHODS: A retrospective cohort analysis was conducted …

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De novo biosynthesis of zeaxanthin and 3-hydroxy-β-ionone by engineered Yarrowia lipolytica

Xinliang Chen, Lei Wang, Yingying Wu, Xin Feng et autres

Zeaxanthin and its derivatives have an increasing market demand owing to their strong antioxidant, anti-cancer, and anti-inflammatory properties.

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Impact of inhaled corticosteroid use on elderly chronic pulmonary disease patients with community acquired pneumonia

Xiudi Han, Wang Hong, Liang Chen, Yimin Wang et autres

To the Editor: With an aging global population, the incidences of community-acquired pneumonia (CAP) and chronic obstructive pulmonary disease (COPD) have significantly increased.[1] Previous studies have confirmed that COPD and asthma are independently associated with the prevalence of CAP. The use of …

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Mortality in patients with incident rheumatoid arthritis and depression: a Danish cohort study of 11 071 patients and 55 355 comparators

K. Stengaard‐Pedersen, Lei Wang, Nickolaj Risbo, Alma B Pedersen et autres

OBJECTIVES: In patients with RA, the association between mortality and depression has been investigated only in patients with prevalent RA. In this study, we estimated the mortality risk associated with depression, defined as the first filling of a prescription for antidepressants, in …

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Adverse events for monoclonal antibodies in patients with allergic rhinitis: A systematic review and meta-analysis of randomized clinical trials

Yuxi Lin, Weiqing Wang, Zhenzhen Zhu, Surita Aodeng et autres

Adverse events for monoclonal antibodies in patients with allergic rhinitis: A systematic review and meta-analysis of randomized clinical trials.Inplasy protocol 202310092.

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The effectiveness and safety of total glucosides of paeony in systemic lupus erythematosus: A systematic review and meta-analysis

Mengjie Wang, Zhiyuan Wang, Ying Liu, Lei Wang et autres

BACKGROUND: To evaluate the efficacy and safety of total glucosides of paeony in the treatment of systemic lupus erythematosus (SLE). METHODS: From the creation of the database to July 2021, multiple databases were searched for randomized controlled trials of treating SLE with …

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