Jian Wu

Multi-Omics and Single-Cell Mendelian Randomization Reveal a Potential Role of VNN2 in Lung Adenocarcinoma in Resting Natural Killer Cells

Zhi Chun Xue, Jing Lin, Jian Wu, Zhi Wen Peng et autres

Background: We aimed to evaluate the potential association between genetically predicted vanin-2 (VNN2) expression and lung adenocarcinoma (LUAD) risk, and to explore the immune cell subtype that may underlie this relationship. Methods: We integrated whole-blood expression quantitative trait loci (eQTL) data from …

cn (code pays fourni par la source)

Efficacy and safety of Janus kinase 1/2 inhibitor KL130008 in active rheumatoid arthritis: a randomized, double-blind, placebo-controlled phase II trial

Yue Cheng, Honghu Tang, Yufeng Qing, Yuan Liu et autres

BACKGROUND: KL130008 is a selective Janus kinase 1/2 inhibitor with encouraging preclinical efficacy. Phase I trials in healthy volunteers and patients with rheumatoid arthritis (RA) showed favorable pharmacokinetics, dose-dependent inhibition of phosphorylated signal transducer and activator of transcription 3, good tolerability, and …

cn, us (code pays fourni par la source)

Supplementary Data from Discovery of a Small-Molecule Inhibitor Targeting the Androgen Receptor N-Terminal Domain for Castration-Resistant Prostate Cancer

Qianhui Yi, Weiguo Liu, Jung Hwa Seo, Jie Su et autres

Supplementary figures and methods

Deoxycholic Acid and Lipoteichoic Acid cooperatively drive macrophage M2/M1 polarization via TGR5/STAT3 and TLR2/NF-κB to fuel HCC progression in obesity

Jian Wu, Wen Zheng, X Ding, Qingyuan Jin et autres

Background: Obesity-related hepatocellular carcinoma (HCC) is associated with gut microbiota dysbiosis. However, the specific roles of key microbial metabolites, deoxycholic acid (DCA) and lipoteichoic acid (LTA), in modulating the immune microenvironment and promoting HCC progression are not fully understood. Aim: This study …

cn, us (code pays fourni par la source)

Association between volatile organic compound co-exposure and the prevalence of rheumatoid arthritis: a nationwide cross-sectional study

Tian Ren, Erye Zhou, Cheng Tao, Mingjun Wang et autres

Background: Environmental contaminants, especially volatile organic compounds (VOCs) and their metabolites (mVOCs), are of significant interest for treating autoimmune diseases due to their potential immunomodulatory effects. This study aimed to assess the association between urinary mVOCs and the risk of rheumatoid arthritis …

cn (code pays fourni par la source)

Age-stratified risk factors and predictive models for progression to lupus nephritis in patients with systemic lupus erythematosus: a review

Shuyu Sun, Song Li, Xin Chang, Jian Wu

Systemic lupus erythematosus (SLE) is a highly heterogeneous autoimmune disorder, and lupus nephritis (LN) is one of its most severe organ manifestations. The age at disease onset is a critical factor influencing the clinical phenotype, disease progression, and prognosis of SLE. However, …

cn (code pays fourni par la source)

RXR agonist IRX4204 induces ferroptosis in multiple myeloma via HMOX1/GPX4 axis and enhances lenalidomide efficacy

Jian Wu, Zhibo Yan, Kimberly Burcher, Zhannan Han et autres

Abstract Background Multiple myeloma (MM) remains incurable despite therapeutic advances, necessitating novel treatment strategies. Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation, represents an emerging therapeutic vulnerability in hematologic malignancies. Our previous studies demonstrated that retinoid X receptor …

us (code pays fourni par la source)

RXR agonist IRX4204 enhances BCMA CAR-T-cell efficacy by suppressing ferroptosis via CHAC1 downregulation

Jian Wu, Ying Zhou, Kimberly Burcher, Louisa Wirthlin et autres

Abstract Background Chimeric antigen receptor (CAR) T-cell therapy targeting B cell maturation antigen (BCMA) shows remarkable efficacy in multiple myeloma (MM), but long-term success is limited by CAR-T cell exhaustion and poor persistence, highlighting the critical need for innovative strategies to enhance …

us (code pays fourni par la source)

Targeting STK17B kinase activates ferroptosis and suppresses drug resistance in multiple myeloma

Zhibo Yan, Zhannan Han, Yihui Wang, Maja Beus et autres

ABSTRACT: The progression of multiple myeloma (MM), an incurable malignancy of plasma cells, is often associated with the suppression of ferroptosis, a type of cell death driven by iron-dependent lipid peroxidation. The mechanisms underlying this suppression remain largely unknown. Here, we identified …

us, sg, nl (code pays fourni par la source)

Associations of neutrophil-based inflammatory markers with all-cause and cardiovascular mortality in individuals with osteoarthritis

Tingting Wu, Yue Xiong, Lei Wang, Erye Zhou et autres

cn (code pays fourni par la source)

[The IL-23p19 monoclonal antibody significantly alleviates nephritis in MRL/lpr lupus mice by modulating the Th17/Treg balance].

Wei Cheng, Saizhe Song, Yu Shen, Cuiping Liu et autres

Objective To investigate the therapeutic effects of interleukin 23p19(IL-23p19) monoclonal antibody in the MRL/lpr lupus-like mouse model. Methods A total of 36 female MRL/lpr mice aged 8 weeks were randomly divided into 6 groups: PBS group (blank control), IgG group (isotype IgG), …

cn (code pays fourni par la source)

ABS0379 MONOCLONAL ANTI-TUMOR NECROSIS FACTOR-ALPHA ANTIBODIES FOR VASCULAR BEHÇET'S SYNDROME: A META-ANALYSIS

Jian Wu, Yan Liu, Ao Yang, Xiaodong Wang et autres

Background: Behçet's syndrome (BS) is a chronic systemic vasculitis in which vascular involvement contributes significantly to morbidity and mortality. For refractory vascular BS (VBS), monoclonal anti-tumor necrosis factor (TNF) antibodies have been recommended beyond glucocorticoids (GCs) and immunosuppressants [1, 2]. However, these …

cn (code pays fourni par la source)